Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies
Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P 71 D 3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P 71 D 3 -based micelle of an average diameter of 100 nm was found to be biocompatible, non-toxic and physically stable in co...
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| Format: | Article |
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Elsevier
2017
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| _version_ | 1796961708916342784 |
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| author | Voon, Siew Hui Kue, Chin Siang Imae, Toyoko Saw, Wen Shang Lee, Hong Boon Kiew, Lik Voon Chung, Lip Yong Yusa, Shin-ichi |
| author_facet | Voon, Siew Hui Kue, Chin Siang Imae, Toyoko Saw, Wen Shang Lee, Hong Boon Kiew, Lik Voon Chung, Lip Yong Yusa, Shin-ichi |
| author_sort | Voon, Siew Hui |
| collection | UM |
| description | Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P 71 D 3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P 71 D 3 -based micelle of an average diameter of 100 nm was found to be biocompatible, non-toxic and physically stable in colloidal system up to 15 days. It enhanced the in vitro potency of doxorubicin (DOX) in 4T1 breast tumor cells by increasing its uptake, by 3-fold, compared to free DOX. In 4T1 tumor-bearing mice, the tumor growth rate of P 71 D 3 /DOX (2 mg/kg DOX equivalent) treated group was significantly delayed and their tumor volume was significantly reduced by 1.5-fold compared to those treated with free DOX. The biodistribution studies indicated that P 71 D 3 /DOX enhanced accumulation of DOX in tumor by 5- and 2-fold higher than free DOX treated mice at 15 min and 1 h post-administration, respectively. These results suggest that P 71 D 3 micelle is a promising nanocarrier for chemotherapeutic agents. |
| first_indexed | 2024-03-06T05:58:10Z |
| format | Article |
| id | um.eprints-22841 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:58:10Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-228412019-10-24T05:05:42Z http://eprints.um.edu.my/22841/ Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies Voon, Siew Hui Kue, Chin Siang Imae, Toyoko Saw, Wen Shang Lee, Hong Boon Kiew, Lik Voon Chung, Lip Yong Yusa, Shin-ichi R Medicine Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P 71 D 3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P 71 D 3 -based micelle of an average diameter of 100 nm was found to be biocompatible, non-toxic and physically stable in colloidal system up to 15 days. It enhanced the in vitro potency of doxorubicin (DOX) in 4T1 breast tumor cells by increasing its uptake, by 3-fold, compared to free DOX. In 4T1 tumor-bearing mice, the tumor growth rate of P 71 D 3 /DOX (2 mg/kg DOX equivalent) treated group was significantly delayed and their tumor volume was significantly reduced by 1.5-fold compared to those treated with free DOX. The biodistribution studies indicated that P 71 D 3 /DOX enhanced accumulation of DOX in tumor by 5- and 2-fold higher than free DOX treated mice at 15 min and 1 h post-administration, respectively. These results suggest that P 71 D 3 micelle is a promising nanocarrier for chemotherapeutic agents. Elsevier 2017 Article PeerReviewed Voon, Siew Hui and Kue, Chin Siang and Imae, Toyoko and Saw, Wen Shang and Lee, Hong Boon and Kiew, Lik Voon and Chung, Lip Yong and Yusa, Shin-ichi (2017) Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies. International Journal of Pharmaceutics, 534 (1-2). pp. 136-143. ISSN 0378-5173, DOI https://doi.org/10.1016/j.ijpharm.2017.10.023 <https://doi.org/10.1016/j.ijpharm.2017.10.023>. https://doi.org/10.1016/j.ijpharm.2017.10.023 doi:10.1016/j.ijpharm.2017.10.023 |
| spellingShingle | R Medicine Voon, Siew Hui Kue, Chin Siang Imae, Toyoko Saw, Wen Shang Lee, Hong Boon Kiew, Lik Voon Chung, Lip Yong Yusa, Shin-ichi Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies |
| title | Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies |
| title_full | Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies |
| title_fullStr | Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies |
| title_full_unstemmed | Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies |
| title_short | Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies |
| title_sort | doxorubicin loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy in vitro and in vivo studies |
| topic | R Medicine |
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