Synthesis and characterization of organotin (IV) complexes derived of 3-(dimethylamino)benzoic acid: In vitro antibacterial screening activity
Organotin(IV) carboxylate complexes derivative of 3-(dimethylamino)benzoic acid, 3-[N(CH3)2]C6H4COOH have been successfully synthesized. Two types of diorganotin(IV) complexes, [{3-[N(CH3)2]C6H4COO(R)2Sn}2O]2 dimer (R= methyl 1, butyl 3) and {3-[N(CH3)2]C6H4COO}2 (C4H9)2Sn, 2 (monomer) as well as 3-...
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American-Eurasian Network for Scientific Information, Jordan
2010
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| author | Win, Yip Foo Teoh, Siang Guan Vikneswaran, Murugaiyah Sivasothy, Yasodha Ha, Sie Tiong Ibrahim, Pazilah |
| author_facet | Win, Yip Foo Teoh, Siang Guan Vikneswaran, Murugaiyah Sivasothy, Yasodha Ha, Sie Tiong Ibrahim, Pazilah |
| author_sort | Win, Yip Foo |
| collection | UM |
| description | Organotin(IV) carboxylate complexes derivative of 3-(dimethylamino)benzoic acid, 3-[N(CH3)2]C6H4COOH have been successfully synthesized. Two types of diorganotin(IV) complexes, [{3-[N(CH3)2]C6H4COO(R)2Sn}2O]2 dimer (R= methyl 1, butyl 3) and {3-[N(CH3)2]C6H4COO}2 (C4H9)2Sn, 2 (monomer) as well as 3-[N(CH3)2]C6H4COO(C6H5)3Sn, 4 were successfully synthesized and obtained in solid state. The acid and complexes 1 - 4 obtained were characterized quantitatively using C, H, N and Sn elemental analysis as well as spectroscopic methods such as infrared (FTIR) and nuclear magnetic resonance (1H, 13C, 1H-13C HMQC & 119Sn NMR). Infrared spectroscopy showed that the coordination took place via oxygen atoms from the carboxylate anions. From 13C NMR spectroscopy data, the δ(COO) of complexes 1-4 are shifted to lower field compared to the parent acid indicated the coordination of carboxylate anion to the tin atom moiety. Moreover, the complexes obtained were screened for their in vitro antibacterial activity. Complex 4 was found to be most active against Bacillus subtilis and Staphylococcus aureus bacterial strains compared to complexes 1-3. © 2010, INSInet Publication. |
| first_indexed | 2024-03-06T05:58:35Z |
| format | Article |
| id | um.eprints-22983 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:58:35Z |
| publishDate | 2010 |
| publisher | American-Eurasian Network for Scientific Information, Jordan |
| record_format | dspace |
| spelling | um.eprints-229832019-11-14T01:01:09Z http://eprints.um.edu.my/22983/ Synthesis and characterization of organotin (IV) complexes derived of 3-(dimethylamino)benzoic acid: In vitro antibacterial screening activity Win, Yip Foo Teoh, Siang Guan Vikneswaran, Murugaiyah Sivasothy, Yasodha Ha, Sie Tiong Ibrahim, Pazilah Q Science (General) QD Chemistry Organotin(IV) carboxylate complexes derivative of 3-(dimethylamino)benzoic acid, 3-[N(CH3)2]C6H4COOH have been successfully synthesized. Two types of diorganotin(IV) complexes, [{3-[N(CH3)2]C6H4COO(R)2Sn}2O]2 dimer (R= methyl 1, butyl 3) and {3-[N(CH3)2]C6H4COO}2 (C4H9)2Sn, 2 (monomer) as well as 3-[N(CH3)2]C6H4COO(C6H5)3Sn, 4 were successfully synthesized and obtained in solid state. The acid and complexes 1 - 4 obtained were characterized quantitatively using C, H, N and Sn elemental analysis as well as spectroscopic methods such as infrared (FTIR) and nuclear magnetic resonance (1H, 13C, 1H-13C HMQC & 119Sn NMR). Infrared spectroscopy showed that the coordination took place via oxygen atoms from the carboxylate anions. From 13C NMR spectroscopy data, the δ(COO) of complexes 1-4 are shifted to lower field compared to the parent acid indicated the coordination of carboxylate anion to the tin atom moiety. Moreover, the complexes obtained were screened for their in vitro antibacterial activity. Complex 4 was found to be most active against Bacillus subtilis and Staphylococcus aureus bacterial strains compared to complexes 1-3. © 2010, INSInet Publication. American-Eurasian Network for Scientific Information, Jordan 2010 Article PeerReviewed Win, Yip Foo and Teoh, Siang Guan and Vikneswaran, Murugaiyah and Sivasothy, Yasodha and Ha, Sie Tiong and Ibrahim, Pazilah (2010) Synthesis and characterization of organotin (IV) complexes derived of 3-(dimethylamino)benzoic acid: In vitro antibacterial screening activity. Australian Journal of Basic and Applied Sciences, 4 (12). pp. 5923-5931. ISSN 1991-8178, http://www.ajbasweb.com/old/ajbas/2010/5923-5931.pdf |
| spellingShingle | Q Science (General) QD Chemistry Win, Yip Foo Teoh, Siang Guan Vikneswaran, Murugaiyah Sivasothy, Yasodha Ha, Sie Tiong Ibrahim, Pazilah Synthesis and characterization of organotin (IV) complexes derived of 3-(dimethylamino)benzoic acid: In vitro antibacterial screening activity |
| title | Synthesis and characterization of organotin (IV) complexes derived of 3-(dimethylamino)benzoic acid: In vitro antibacterial screening activity |
| title_full | Synthesis and characterization of organotin (IV) complexes derived of 3-(dimethylamino)benzoic acid: In vitro antibacterial screening activity |
| title_fullStr | Synthesis and characterization of organotin (IV) complexes derived of 3-(dimethylamino)benzoic acid: In vitro antibacterial screening activity |
| title_full_unstemmed | Synthesis and characterization of organotin (IV) complexes derived of 3-(dimethylamino)benzoic acid: In vitro antibacterial screening activity |
| title_short | Synthesis and characterization of organotin (IV) complexes derived of 3-(dimethylamino)benzoic acid: In vitro antibacterial screening activity |
| title_sort | synthesis and characterization of organotin iv complexes derived of 3 dimethylamino benzoic acid in vitro antibacterial screening activity |
| topic | Q Science (General) QD Chemistry |
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