Synthesis and structural characterization of organotin (IV) complexes derived of 4- (Diethylamino) benzoic acid: Cytotoxic assay on human liver carcinoma cells (HepG2)
Organotin(IV) carboxylate complexes derived from 4-(diethylamino) benzoic acid, 4-[N(C2H5)2]C6H4COOH have been successfully synthesized. Two types of diorganotin(IV) complexes {4-[N(C2H5)2]C6H4COO}2(R)2Sn (R= methyl 1, butyl 2), [{4-[N(C2H5)2]C6H4COO(C4H9)2Sn}2O]2 dimer 3 and 4-[N(C2H5)2]C6H4COO(C6H...
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American-Eurasian Network for Scientific Information, Jordan
2010
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| author | Win, Yip Foo Teoh, Siang Guan Tengku-Muhammad, Tengku Sifzizul Ha, Sie Tiong Sivasothy, Yasodha |
| author_facet | Win, Yip Foo Teoh, Siang Guan Tengku-Muhammad, Tengku Sifzizul Ha, Sie Tiong Sivasothy, Yasodha |
| author_sort | Win, Yip Foo |
| collection | UM |
| description | Organotin(IV) carboxylate complexes derived from 4-(diethylamino) benzoic acid, 4-[N(C2H5)2]C6H4COOH have been successfully synthesized. Two types of diorganotin(IV) complexes {4-[N(C2H5)2]C6H4COO}2(R)2Sn (R= methyl 1, butyl 2), [{4-[N(C2H5)2]C6H4COO(C4H9)2Sn}2O]2 dimer 3 and 4-[N(C2H5)2]C6H4COO(C6H5)3Sn 4 were successfully synthesized and obtained in solid state. The acid and complexes 1-4 obtained were characterized quantitatively using C, H, N and Sn elemental analysis as well as spectroscopic methods such as infrared (FTIR) and nuclear magnetic resonance (1H, 13C & 119Sn NMR). Results of the infrared and NMR spectroscopy on the acid and complexes showed that the coordination took place via oxygen atoms from the carboxylate group. As a result, the tin atom of complex 2 is six-coordinated, complex 4 is four-coordinated and tin atoms of complex 3 are five- and six-coordinated. With the exceptional case the tin atom of complex 1 exhibited five and six coordination in solution state which may be attributed from the dynamic stage or partial disassociation bonding of carboxylate anion. From the cytotoxic assay study, complex 4 revealed a significant result compared to complexes 1-3. © 2010, INSInet Publication. |
| first_indexed | 2024-03-06T05:58:35Z |
| format | Article |
| id | um.eprints-22984 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:58:35Z |
| publishDate | 2010 |
| publisher | American-Eurasian Network for Scientific Information, Jordan |
| record_format | dspace |
| spelling | um.eprints-229842019-11-14T02:05:44Z http://eprints.um.edu.my/22984/ Synthesis and structural characterization of organotin (IV) complexes derived of 4- (Diethylamino) benzoic acid: Cytotoxic assay on human liver carcinoma cells (HepG2) Win, Yip Foo Teoh, Siang Guan Tengku-Muhammad, Tengku Sifzizul Ha, Sie Tiong Sivasothy, Yasodha Q Science (General) QD Chemistry Organotin(IV) carboxylate complexes derived from 4-(diethylamino) benzoic acid, 4-[N(C2H5)2]C6H4COOH have been successfully synthesized. Two types of diorganotin(IV) complexes {4-[N(C2H5)2]C6H4COO}2(R)2Sn (R= methyl 1, butyl 2), [{4-[N(C2H5)2]C6H4COO(C4H9)2Sn}2O]2 dimer 3 and 4-[N(C2H5)2]C6H4COO(C6H5)3Sn 4 were successfully synthesized and obtained in solid state. The acid and complexes 1-4 obtained were characterized quantitatively using C, H, N and Sn elemental analysis as well as spectroscopic methods such as infrared (FTIR) and nuclear magnetic resonance (1H, 13C & 119Sn NMR). Results of the infrared and NMR spectroscopy on the acid and complexes showed that the coordination took place via oxygen atoms from the carboxylate group. As a result, the tin atom of complex 2 is six-coordinated, complex 4 is four-coordinated and tin atoms of complex 3 are five- and six-coordinated. With the exceptional case the tin atom of complex 1 exhibited five and six coordination in solution state which may be attributed from the dynamic stage or partial disassociation bonding of carboxylate anion. From the cytotoxic assay study, complex 4 revealed a significant result compared to complexes 1-3. © 2010, INSInet Publication. American-Eurasian Network for Scientific Information, Jordan 2010 Article PeerReviewed Win, Yip Foo and Teoh, Siang Guan and Tengku-Muhammad, Tengku Sifzizul and Ha, Sie Tiong and Sivasothy, Yasodha (2010) Synthesis and structural characterization of organotin (IV) complexes derived of 4- (Diethylamino) benzoic acid: Cytotoxic assay on human liver carcinoma cells (HepG2). Australian Journal of Basic and Applied Sciences, 4 (6). pp. 1383-1390. ISSN 1991-8178, http://www.ajbasweb.com/old/ajbas/2010/1383-1390.pdf |
| spellingShingle | Q Science (General) QD Chemistry Win, Yip Foo Teoh, Siang Guan Tengku-Muhammad, Tengku Sifzizul Ha, Sie Tiong Sivasothy, Yasodha Synthesis and structural characterization of organotin (IV) complexes derived of 4- (Diethylamino) benzoic acid: Cytotoxic assay on human liver carcinoma cells (HepG2) |
| title | Synthesis and structural characterization of organotin (IV) complexes derived of 4- (Diethylamino) benzoic acid: Cytotoxic assay on human liver carcinoma cells (HepG2) |
| title_full | Synthesis and structural characterization of organotin (IV) complexes derived of 4- (Diethylamino) benzoic acid: Cytotoxic assay on human liver carcinoma cells (HepG2) |
| title_fullStr | Synthesis and structural characterization of organotin (IV) complexes derived of 4- (Diethylamino) benzoic acid: Cytotoxic assay on human liver carcinoma cells (HepG2) |
| title_full_unstemmed | Synthesis and structural characterization of organotin (IV) complexes derived of 4- (Diethylamino) benzoic acid: Cytotoxic assay on human liver carcinoma cells (HepG2) |
| title_short | Synthesis and structural characterization of organotin (IV) complexes derived of 4- (Diethylamino) benzoic acid: Cytotoxic assay on human liver carcinoma cells (HepG2) |
| title_sort | synthesis and structural characterization of organotin iv complexes derived of 4 diethylamino benzoic acid cytotoxic assay on human liver carcinoma cells hepg2 |
| topic | Q Science (General) QD Chemistry |
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