Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives
A library of some new fluorescent chromenopyrimidine derivatives has been synthesized by new approaches. Water-promoted and one-pot reaction can produce new dialkylylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl) phenols. These compounds can also be produced using domino reaction. Two parallel methods are...
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| Format: | Article |
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American Chemical Society
2013
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| _version_ | 1825721990069092352 |
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| author | Zonouzi, Afsaneh Hosseinzadeh, Fatemeh Karimi, Nastaran Mirzazadeh, Roghieh Ng, Seik Weng |
| author_facet | Zonouzi, Afsaneh Hosseinzadeh, Fatemeh Karimi, Nastaran Mirzazadeh, Roghieh Ng, Seik Weng |
| author_sort | Zonouzi, Afsaneh |
| collection | UM |
| description | A library of some new fluorescent chromenopyrimidine derivatives has been synthesized by new approaches. Water-promoted and one-pot reaction can produce new dialkylylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl) phenols. These compounds can also be produced using domino reaction. Two parallel methods are compared. Novel N-alkyl-N-phenyl-5H-chromeno[2,3-d]-pyrimidin-4-amines and 4-alkoxy-5H-chromeno[2, 3-d]pyrimidines are synthesized by Lewis-acid catalyzed reactions. The fluorescence emission intensity of the four compounds from each of libraries after excitation in 290 nm is measured. Compound 2-(4,5-bis(N-methyl-N-phenylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol was isolated as a byproduct. The details of an interesting exchangeable intramolecular H- bonding of two of the new compounds are reported by X-ray analysis data. © 2013 American Chemical Society. |
| first_indexed | 2024-03-06T05:58:46Z |
| format | Article |
| id | um.eprints-23067 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:58:46Z |
| publishDate | 2013 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | um.eprints-230672019-11-19T08:56:30Z http://eprints.um.edu.my/23067/ Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives Zonouzi, Afsaneh Hosseinzadeh, Fatemeh Karimi, Nastaran Mirzazadeh, Roghieh Ng, Seik Weng Q Science (General) QD Chemistry A library of some new fluorescent chromenopyrimidine derivatives has been synthesized by new approaches. Water-promoted and one-pot reaction can produce new dialkylylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl) phenols. These compounds can also be produced using domino reaction. Two parallel methods are compared. Novel N-alkyl-N-phenyl-5H-chromeno[2,3-d]-pyrimidin-4-amines and 4-alkoxy-5H-chromeno[2, 3-d]pyrimidines are synthesized by Lewis-acid catalyzed reactions. The fluorescence emission intensity of the four compounds from each of libraries after excitation in 290 nm is measured. Compound 2-(4,5-bis(N-methyl-N-phenylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol was isolated as a byproduct. The details of an interesting exchangeable intramolecular H- bonding of two of the new compounds are reported by X-ray analysis data. © 2013 American Chemical Society. American Chemical Society 2013 Article PeerReviewed Zonouzi, Afsaneh and Hosseinzadeh, Fatemeh and Karimi, Nastaran and Mirzazadeh, Roghieh and Ng, Seik Weng (2013) Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives. ACS Combinatorial Science, 15 (5). pp. 240-246. ISSN 2156-8952, DOI https://doi.org/10.1021/co300141j <https://doi.org/10.1021/co300141j>. https://doi.org/10.1021/co300141j doi:10.1021/co300141j |
| spellingShingle | Q Science (General) QD Chemistry Zonouzi, Afsaneh Hosseinzadeh, Fatemeh Karimi, Nastaran Mirzazadeh, Roghieh Ng, Seik Weng Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives |
| title | Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives |
| title_full | Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives |
| title_fullStr | Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives |
| title_full_unstemmed | Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives |
| title_short | Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives |
| title_sort | novel approaches for the synthesis of a library of fluorescent chromenopyrimidine derivatives |
| topic | Q Science (General) QD Chemistry |
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