Discovery of a New Class of Immunosuppressants fromTrichothecium roseumCo-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif
The limited selection of immunosuppressants in the clinic hampers the efficient management of immune disorders such as rejections after organ transplantations. However, the search for new immunosuppressive compounds remains random and creates inevitably financial and laborious wastes. Herein, we pre...
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| Format: | Article |
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Wiley
2013
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| _version_ | 1796961752031690752 |
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| author | Zhang, Ai Hua Wang, Xing Qi Han, Wen Bo Sun, Yang Guo, Ye Wu, Qi Ge, Hui Ming Song, Yong Chun Ng, Seik Weng Xu, Qiang Tan, Ren Xiang |
| author_facet | Zhang, Ai Hua Wang, Xing Qi Han, Wen Bo Sun, Yang Guo, Ye Wu, Qi Ge, Hui Ming Song, Yong Chun Ng, Seik Weng Xu, Qiang Tan, Ren Xiang |
| author_sort | Zhang, Ai Hua |
| collection | UM |
| description | The limited selection of immunosuppressants in the clinic hampers the efficient management of immune disorders such as rejections after organ transplantations. However, the search for new immunosuppressive compounds remains random and creates inevitably financial and laborious wastes. Herein, we present an immunity-inspired discovery strategy that rationally allows an efficient identification of immunosuppressive compounds from the endophyte culture, as exemplified by the new peptide trichomide A. This compound exerts its immunosuppressive action more selectively than cyclosporin A. It was found that trichomide A decreases the expression of Bcl-2, increases the expression of Bax, and has a small or negligible effect on the expressions of p-Akt, CD25, and CD69. Our study strengthens the idea that the cross-kingdom similarity in immunity among living things could provide a shorter route towards the identification of natural products valuable for the development of new immunosuppressants. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| first_indexed | 2024-03-06T05:58:48Z |
| format | Article |
| id | um.eprints-23076 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:58:48Z |
| publishDate | 2013 |
| publisher | Wiley |
| record_format | dspace |
| spelling | um.eprints-230762019-11-20T03:45:50Z http://eprints.um.edu.my/23076/ Discovery of a New Class of Immunosuppressants fromTrichothecium roseumCo-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif Zhang, Ai Hua Wang, Xing Qi Han, Wen Bo Sun, Yang Guo, Ye Wu, Qi Ge, Hui Ming Song, Yong Chun Ng, Seik Weng Xu, Qiang Tan, Ren Xiang Q Science (General) QD Chemistry The limited selection of immunosuppressants in the clinic hampers the efficient management of immune disorders such as rejections after organ transplantations. However, the search for new immunosuppressive compounds remains random and creates inevitably financial and laborious wastes. Herein, we present an immunity-inspired discovery strategy that rationally allows an efficient identification of immunosuppressive compounds from the endophyte culture, as exemplified by the new peptide trichomide A. This compound exerts its immunosuppressive action more selectively than cyclosporin A. It was found that trichomide A decreases the expression of Bcl-2, increases the expression of Bax, and has a small or negligible effect on the expressions of p-Akt, CD25, and CD69. Our study strengthens the idea that the cross-kingdom similarity in immunity among living things could provide a shorter route towards the identification of natural products valuable for the development of new immunosuppressants. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Wiley 2013 Article PeerReviewed Zhang, Ai Hua and Wang, Xing Qi and Han, Wen Bo and Sun, Yang and Guo, Ye and Wu, Qi and Ge, Hui Ming and Song, Yong Chun and Ng, Seik Weng and Xu, Qiang and Tan, Ren Xiang (2013) Discovery of a New Class of Immunosuppressants fromTrichothecium roseumCo-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif. Chemistry - An Asian Journal, 8 (12). pp. 3101-3107. ISSN 1861-4728, DOI https://doi.org/10.1002/asia.201300734 <https://doi.org/10.1002/asia.201300734>. https://doi.org/10.1002/asia.201300734 doi:10.1002/asia.201300734 |
| spellingShingle | Q Science (General) QD Chemistry Zhang, Ai Hua Wang, Xing Qi Han, Wen Bo Sun, Yang Guo, Ye Wu, Qi Ge, Hui Ming Song, Yong Chun Ng, Seik Weng Xu, Qiang Tan, Ren Xiang Discovery of a New Class of Immunosuppressants fromTrichothecium roseumCo-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif |
| title | Discovery of a New Class of Immunosuppressants fromTrichothecium roseumCo-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif |
| title_full | Discovery of a New Class of Immunosuppressants fromTrichothecium roseumCo-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif |
| title_fullStr | Discovery of a New Class of Immunosuppressants fromTrichothecium roseumCo-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif |
| title_full_unstemmed | Discovery of a New Class of Immunosuppressants fromTrichothecium roseumCo-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif |
| title_short | Discovery of a New Class of Immunosuppressants fromTrichothecium roseumCo-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif |
| title_sort | discovery of a new class of immunosuppressants fromtrichothecium roseumco inspired by cross kingdom similarity in innate immunity and pharmacophore motif |
| topic | Q Science (General) QD Chemistry |
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