High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia
Rickettsioses of the typhus group (TG) and spotted fever group (SFG) are emerging bacterial infections worldwide, especially in the tropics. Only a few studies on these pathogens and their respective clinical diseases have been conducted in Malaysia. Here, we performed a seroprevalence study among 5...
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| Format: | Article |
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Mary Ann Liebert
2019
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| author | Tappe, Dennis Gross, Yvonne Ngui, Romano Rauch, Jessica Tay, Sun Tee Lim, Yvonne Ai Lian |
| author_facet | Tappe, Dennis Gross, Yvonne Ngui, Romano Rauch, Jessica Tay, Sun Tee Lim, Yvonne Ai Lian |
| author_sort | Tappe, Dennis |
| collection | UM |
| description | Rickettsioses of the typhus group (TG) and spotted fever group (SFG) are emerging bacterial infections worldwide, especially in the tropics. Only a few studies on these pathogens and their respective clinical diseases have been conducted in Malaysia. Here, we performed a seroprevalence study among 544 healthy, afebrile indigenous people (Orang Asli) from peninsular Malaysia for TG and SFG rickettsioses in nine rural and peri-urban settlements. The study population encompassed children, adolescents, and adults. The overall seroprevalence of rickettsiosis in the Orang Asli was 48.5%, with 27.9% seroprevalence against TG rickettsiae and 20.6% seroprevalence against SFG rickettsiae. In 7.9% of the study participants, antibodies against both rickettsial groups were found. The highest seropositivity rates against TG and SRG rickettsiae were detected in young children and adults. Overall, there were no gender differences. Seroprevalences were similar among inhabitants of different settlements, except for two localities. More studies are needed to shed more light on the ecology and risk factors for TG and SFG rickettsioses in Malaysia. © Copyright 2019, Mary Ann Liebert, Inc., publishers 2019. |
| first_indexed | 2024-03-06T05:59:25Z |
| format | Article |
| id | um.eprints-23279 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:59:25Z |
| publishDate | 2019 |
| publisher | Mary Ann Liebert |
| record_format | dspace |
| spelling | um.eprints-232792019-12-23T03:04:07Z http://eprints.um.edu.my/23279/ High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia Tappe, Dennis Gross, Yvonne Ngui, Romano Rauch, Jessica Tay, Sun Tee Lim, Yvonne Ai Lian R Medicine Rickettsioses of the typhus group (TG) and spotted fever group (SFG) are emerging bacterial infections worldwide, especially in the tropics. Only a few studies on these pathogens and their respective clinical diseases have been conducted in Malaysia. Here, we performed a seroprevalence study among 544 healthy, afebrile indigenous people (Orang Asli) from peninsular Malaysia for TG and SFG rickettsioses in nine rural and peri-urban settlements. The study population encompassed children, adolescents, and adults. The overall seroprevalence of rickettsiosis in the Orang Asli was 48.5%, with 27.9% seroprevalence against TG rickettsiae and 20.6% seroprevalence against SFG rickettsiae. In 7.9% of the study participants, antibodies against both rickettsial groups were found. The highest seropositivity rates against TG and SRG rickettsiae were detected in young children and adults. Overall, there were no gender differences. Seroprevalences were similar among inhabitants of different settlements, except for two localities. More studies are needed to shed more light on the ecology and risk factors for TG and SFG rickettsioses in Malaysia. © Copyright 2019, Mary Ann Liebert, Inc., publishers 2019. Mary Ann Liebert 2019 Article PeerReviewed Tappe, Dennis and Gross, Yvonne and Ngui, Romano and Rauch, Jessica and Tay, Sun Tee and Lim, Yvonne Ai Lian (2019) High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia. Vector-Borne and Zoonotic Diseases, 19 (5). pp. 323-327. ISSN 1530-3667, DOI https://doi.org/10.1089/vbz.2018.2391 <https://doi.org/10.1089/vbz.2018.2391>. https://doi.org/10.1089/vbz.2018.2391 doi:10.1089/vbz.2018.2391 |
| spellingShingle | R Medicine Tappe, Dennis Gross, Yvonne Ngui, Romano Rauch, Jessica Tay, Sun Tee Lim, Yvonne Ai Lian High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia |
| title | High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia |
| title_full | High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia |
| title_fullStr | High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia |
| title_full_unstemmed | High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia |
| title_short | High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia |
| title_sort | high seroprevalence against typhus group and spotted fever group rickettsiae in rural indigenous populations of peninsular malaysia |
| topic | R Medicine |
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