Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants
Microbial natural products serve as a good source for antioxidants. The mangrove-derived Streptomyces bacteria have been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants...
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| Format: | Article |
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Wiley Open Access
2019
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| _version_ | 1796961795300130816 |
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| author | Tan, Loh Teng Hern Mahendra, Camille Keisha Yow, Yoon Yen Chan, Kok Gan Khan, Tahir Mehmood Lee, Learn Han Goh, Bey Hing |
| author_facet | Tan, Loh Teng Hern Mahendra, Camille Keisha Yow, Yoon Yen Chan, Kok Gan Khan, Tahir Mehmood Lee, Learn Han Goh, Bey Hing |
| author_sort | Tan, Loh Teng Hern |
| collection | UM |
| description | Microbial natural products serve as a good source for antioxidants. The mangrove-derived Streptomyces bacteria have been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants and UV-protective agents. Identification and characterization methods determine that strain MUM273b belongs to the genus Streptomyces. The MUM273b extract exhibits antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging activities and also metal-chelating activity. The MUM273b extract was also shown to inhibit the production of malondialdehyde in metal-induced lipid peroxidation. Strong correlation between the antioxidant activities and the total phenolic content of MUM273b extract was shown. In addition, MUM273b extract exhibited cytoprotective effect on the UVB-induced cell death in HaCaT keratinocytes. Gas chromatography–mass spectrometry analysis detected phenolics, pyrrole, pyrazine, ester, and cyclic dipeptides in MUM273b extract. In summary, Streptomyces MUM273b extract portrays an exciting avenue for future antioxidative drugs and cosmeceuticals development. © 2019 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd. |
| first_indexed | 2024-03-06T05:59:28Z |
| format | Article |
| id | um.eprints-23300 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:59:28Z |
| publishDate | 2019 |
| publisher | Wiley Open Access |
| record_format | dspace |
| spelling | um.eprints-233002020-01-03T05:41:59Z http://eprints.um.edu.my/23300/ Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants Tan, Loh Teng Hern Mahendra, Camille Keisha Yow, Yoon Yen Chan, Kok Gan Khan, Tahir Mehmood Lee, Learn Han Goh, Bey Hing Q Science (General) QH Natural history QR Microbiology Microbial natural products serve as a good source for antioxidants. The mangrove-derived Streptomyces bacteria have been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants and UV-protective agents. Identification and characterization methods determine that strain MUM273b belongs to the genus Streptomyces. The MUM273b extract exhibits antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging activities and also metal-chelating activity. The MUM273b extract was also shown to inhibit the production of malondialdehyde in metal-induced lipid peroxidation. Strong correlation between the antioxidant activities and the total phenolic content of MUM273b extract was shown. In addition, MUM273b extract exhibited cytoprotective effect on the UVB-induced cell death in HaCaT keratinocytes. Gas chromatography–mass spectrometry analysis detected phenolics, pyrrole, pyrazine, ester, and cyclic dipeptides in MUM273b extract. In summary, Streptomyces MUM273b extract portrays an exciting avenue for future antioxidative drugs and cosmeceuticals development. © 2019 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd. Wiley Open Access 2019 Article PeerReviewed Tan, Loh Teng Hern and Mahendra, Camille Keisha and Yow, Yoon Yen and Chan, Kok Gan and Khan, Tahir Mehmood and Lee, Learn Han and Goh, Bey Hing (2019) Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants. MicrobiologyOpen, 8 (10). e859. ISSN 2045-8827, DOI https://doi.org/10.1002/mbo3.859 <https://doi.org/10.1002/mbo3.859>. https://doi.org/10.1002/mbo3.859 doi:10.1002/mbo3.859 |
| spellingShingle | Q Science (General) QH Natural history QR Microbiology Tan, Loh Teng Hern Mahendra, Camille Keisha Yow, Yoon Yen Chan, Kok Gan Khan, Tahir Mehmood Lee, Learn Han Goh, Bey Hing Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title | Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title_full | Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title_fullStr | Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title_full_unstemmed | Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title_short | Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants |
| title_sort | streptomyces sp mum273b a mangrove derived potential source for antioxidant and uvb radiation protectants |
| topic | Q Science (General) QH Natural history QR Microbiology |
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