Dengue protease inhibition activity of selected malaysian medicinal herbs
Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In...
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Malaysian Society of Parasitology and Tropical Medicine
2019
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| author | Salleh, H.M. Chong, Soon Lim Othman, Rozana Hazni, Hazrina Ahmad, Khadher Mohd Yusoff, Mohd Yakub @ Zulkifli Fauzi, Nurulwahidah Wahab, Habibah A. Liew, Sook Yee Awang, Khalijah |
| author_facet | Salleh, H.M. Chong, Soon Lim Othman, Rozana Hazni, Hazrina Ahmad, Khadher Mohd Yusoff, Mohd Yakub @ Zulkifli Fauzi, Nurulwahidah Wahab, Habibah A. Liew, Sook Yee Awang, Khalijah |
| author_sort | Salleh, H.M. |
| collection | UM |
| description | Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 µg/mL with IC50 value of 0.30 ± 0.16 µg/mL. © 2019, Malaysian Society for Parasitology. All rights reserved. |
| first_indexed | 2024-03-06T06:00:11Z |
| format | Article |
| id | um.eprints-23552 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T06:00:11Z |
| publishDate | 2019 |
| publisher | Malaysian Society of Parasitology and Tropical Medicine |
| record_format | dspace |
| spelling | um.eprints-235522020-01-23T08:13:11Z http://eprints.um.edu.my/23552/ Dengue protease inhibition activity of selected malaysian medicinal herbs Salleh, H.M. Chong, Soon Lim Othman, Rozana Hazni, Hazrina Ahmad, Khadher Mohd Yusoff, Mohd Yakub @ Zulkifli Fauzi, Nurulwahidah Wahab, Habibah A. Liew, Sook Yee Awang, Khalijah BP Islam. Bahaism. Theosophy, etc QD Chemistry R Medicine Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 µg/mL with IC50 value of 0.30 ± 0.16 µg/mL. © 2019, Malaysian Society for Parasitology. All rights reserved. Malaysian Society of Parasitology and Tropical Medicine 2019 Article PeerReviewed Salleh, H.M. and Chong, Soon Lim and Othman, Rozana and Hazni, Hazrina and Ahmad, Khadher and Mohd Yusoff, Mohd Yakub @ Zulkifli and Fauzi, Nurulwahidah and Wahab, Habibah A. and Liew, Sook Yee and Awang, Khalijah (2019) Dengue protease inhibition activity of selected malaysian medicinal herbs. Tropical Biomedicine, 36 (2). pp. 357-366. ISSN 0127-5720, http://msptm.org/files/Vol36No2/357-366-Awang-K.pdf |
| spellingShingle | BP Islam. Bahaism. Theosophy, etc QD Chemistry R Medicine Salleh, H.M. Chong, Soon Lim Othman, Rozana Hazni, Hazrina Ahmad, Khadher Mohd Yusoff, Mohd Yakub @ Zulkifli Fauzi, Nurulwahidah Wahab, Habibah A. Liew, Sook Yee Awang, Khalijah Dengue protease inhibition activity of selected malaysian medicinal herbs |
| title | Dengue protease inhibition activity of selected malaysian medicinal herbs |
| title_full | Dengue protease inhibition activity of selected malaysian medicinal herbs |
| title_fullStr | Dengue protease inhibition activity of selected malaysian medicinal herbs |
| title_full_unstemmed | Dengue protease inhibition activity of selected malaysian medicinal herbs |
| title_short | Dengue protease inhibition activity of selected malaysian medicinal herbs |
| title_sort | dengue protease inhibition activity of selected malaysian medicinal herbs |
| topic | BP Islam. Bahaism. Theosophy, etc QD Chemistry R Medicine |
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