Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia
Leptospirosis is a zoonotic bacterial disease caused by pathogenic species of the genus Leptospira. Disease incidenceisknowntobeattributed toenvironmental and social conditions which promote the spread ofreservoir hosts, primarily rodents. A well-being program was conducted to determine the seroprev...
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American Society of Tropical Medicine and Hygiene
2019
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| _version_ | 1825722086837977088 |
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| author | Sahimin, Norhidayu Sharif, Siti Aishah Mohd Hanapi, Izzah Ruzana Nai Chuan, Sukchinda Lewis, John Watkin Douadi, Benacer Mohd Zain, Siti Nursheena |
| author_facet | Sahimin, Norhidayu Sharif, Siti Aishah Mohd Hanapi, Izzah Ruzana Nai Chuan, Sukchinda Lewis, John Watkin Douadi, Benacer Mohd Zain, Siti Nursheena |
| author_sort | Sahimin, Norhidayu |
| collection | UM |
| description | Leptospirosis is a zoonotic bacterial disease caused by pathogenic species of the genus Leptospira. Disease incidenceisknowntobeattributed toenvironmental and social conditions which promote the spread ofreservoir hosts, primarily rodents. A well-being program was conducted to determine the seroprevalence and risk factors associated with leptospirosis inurban poor communities occupying low-cost flat accommodation and squatter settlements in the vicinity of Wilayah Persekutuan, Kuala Lumpur. Blood samples from a total of 532 volunteers were screened for the detection of IgG and IgM antibodies against leptospirosis using ELISA. Demographic data were collected for each participant through a questionnaire survey before blood collection. The overall seroprevalence was low (12.6%, n = 67/532; 95% CI: 9.9-15.7%), with 8.1% (n=43/532) being seropositive for anti-Leptospira Ig G, indicating previous infection, and 4.9% (n = 26/532) for anti-Leptospira Ig M, indicating current infection. Two significant factors such as host age (P ≤ 0.01) and knowledge of disease transmission (P = 0.017) significantly influenced the presence of anti-Leptospira Ig M, whereas the detection of anti-IgG indicated the presence of clean drinking water sources (P = 0.043). Despite the low prevalence, the transmission of leptospirosis does occur among urban poor communities, suggesting the need for undertaking public awareness programs. Copyright © 2019 by The American Society of Tropical Medicine and Hygiene. |
| first_indexed | 2024-03-06T06:00:17Z |
| format | Article |
| id | um.eprints-23590 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T06:00:17Z |
| publishDate | 2019 |
| publisher | American Society of Tropical Medicine and Hygiene |
| record_format | dspace |
| spelling | um.eprints-235902020-01-28T01:34:39Z http://eprints.um.edu.my/23590/ Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia Sahimin, Norhidayu Sharif, Siti Aishah Mohd Hanapi, Izzah Ruzana Nai Chuan, Sukchinda Lewis, John Watkin Douadi, Benacer Mohd Zain, Siti Nursheena QR Microbiology R Medicine Leptospirosis is a zoonotic bacterial disease caused by pathogenic species of the genus Leptospira. Disease incidenceisknowntobeattributed toenvironmental and social conditions which promote the spread ofreservoir hosts, primarily rodents. A well-being program was conducted to determine the seroprevalence and risk factors associated with leptospirosis inurban poor communities occupying low-cost flat accommodation and squatter settlements in the vicinity of Wilayah Persekutuan, Kuala Lumpur. Blood samples from a total of 532 volunteers were screened for the detection of IgG and IgM antibodies against leptospirosis using ELISA. Demographic data were collected for each participant through a questionnaire survey before blood collection. The overall seroprevalence was low (12.6%, n = 67/532; 95% CI: 9.9-15.7%), with 8.1% (n=43/532) being seropositive for anti-Leptospira Ig G, indicating previous infection, and 4.9% (n = 26/532) for anti-Leptospira Ig M, indicating current infection. Two significant factors such as host age (P ≤ 0.01) and knowledge of disease transmission (P = 0.017) significantly influenced the presence of anti-Leptospira Ig M, whereas the detection of anti-IgG indicated the presence of clean drinking water sources (P = 0.043). Despite the low prevalence, the transmission of leptospirosis does occur among urban poor communities, suggesting the need for undertaking public awareness programs. Copyright © 2019 by The American Society of Tropical Medicine and Hygiene. American Society of Tropical Medicine and Hygiene 2019 Article PeerReviewed Sahimin, Norhidayu and Sharif, Siti Aishah and Mohd Hanapi, Izzah Ruzana and Nai Chuan, Sukchinda and Lewis, John Watkin and Douadi, Benacer and Mohd Zain, Siti Nursheena (2019) Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia. The American Journal of Tropical Medicine and Hygiene, 101 (6). pp. 1265-1271. ISSN 0002-9637, DOI https://doi.org/10.4269/ajtmh.19-0003 <https://doi.org/10.4269/ajtmh.19-0003>. https://doi.org/10.4269/ajtmh.19-0003 doi:10.4269/ajtmh.19-0003 |
| spellingShingle | QR Microbiology R Medicine Sahimin, Norhidayu Sharif, Siti Aishah Mohd Hanapi, Izzah Ruzana Nai Chuan, Sukchinda Lewis, John Watkin Douadi, Benacer Mohd Zain, Siti Nursheena Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia |
| title | Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia |
| title_full | Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia |
| title_fullStr | Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia |
| title_full_unstemmed | Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia |
| title_short | Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia |
| title_sort | seroprevalence of anti leptospira igg and igm antibodies and risk assessment of leptospirosis among urban poor communities in kuala lumpur malaysia |
| topic | QR Microbiology R Medicine |
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