MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset
The MDM2 SNP309 has been associated with increased expression of the protein which could suppress p53 function, and has been shown to modulate risk to cancer. We have previously shown that overexpression of MDM2 is a common event in oral cancers. In the present study, we determined the association b...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier
2009
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| Online Access: | http://eprints.um.edu.my/2381/1/MDM2_SNP309_does_not_confer_an_increased_risk_to_oral_squamous_cell_carcinoma_but_may_modulate_the_age_of_disease_onset.pdf http://eprints.um.edu.my/2381/2/MDM2.pdf |
| _version_ | 1796944854995959808 |
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| author | Zain , R.B. Hamid, S. Yang, YH Peng, K. N. L. Ismail, S.M. Lim, K. P. Wan Mustafa, W. M. Abraham, M. T. Teo, S.H. Cheong, S.C. |
| author_facet | Zain , R.B. Hamid, S. Yang, YH Peng, K. N. L. Ismail, S.M. Lim, K. P. Wan Mustafa, W. M. Abraham, M. T. Teo, S.H. Cheong, S.C. |
| author_sort | Zain , R.B. |
| collection | UM |
| description | The MDM2 SNP309 has been associated with increased expression of the protein which could suppress p53 function, and has been shown to modulate risk to cancer. We have previously shown that overexpression of MDM2 is a common event in oral cancers. In the present study, we determined the association between the MDM2 SNP309 polymorphism and oral cancer in 207 oral cancer patients and 116 normal subjects. We genotyped the MDM2 SNP309 by PCR-RFLP. Logistic regression was adapted to calculate odds ratios for MDM2 SNP309 polymorphism from univariate and multivariable adjusted models. Our results suggest that MDM2 SNP309 does not confer increased risk to oral cancer (OR = 1.55, 95% CI = 0.77-3.11). However, the GG/TG genotype was associated with later disease onset in women above 55 years of age. Collectively, our data suggests that MDM2 SNP309 may modulate the risk to oral cancer and is a modifier of the age at oral cancer onset in women above the age of 55 years. |
| first_indexed | 2024-03-06T05:07:56Z |
| format | Article |
| id | um.eprints-2381 |
| institution | Universiti Malaya |
| language | English English |
| last_indexed | 2024-03-06T05:07:56Z |
| publishDate | 2009 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-23812012-02-14T01:44:24Z http://eprints.um.edu.my/2381/ MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset Zain , R.B. Hamid, S. Yang, YH Peng, K. N. L. Ismail, S.M. Lim, K. P. Wan Mustafa, W. M. Abraham, M. T. Teo, S.H. Cheong, S.C. R Medicine RD Surgery RK Dentistry Oral surger The MDM2 SNP309 has been associated with increased expression of the protein which could suppress p53 function, and has been shown to modulate risk to cancer. We have previously shown that overexpression of MDM2 is a common event in oral cancers. In the present study, we determined the association between the MDM2 SNP309 polymorphism and oral cancer in 207 oral cancer patients and 116 normal subjects. We genotyped the MDM2 SNP309 by PCR-RFLP. Logistic regression was adapted to calculate odds ratios for MDM2 SNP309 polymorphism from univariate and multivariable adjusted models. Our results suggest that MDM2 SNP309 does not confer increased risk to oral cancer (OR = 1.55, 95% CI = 0.77-3.11). However, the GG/TG genotype was associated with later disease onset in women above 55 years of age. Collectively, our data suggests that MDM2 SNP309 may modulate the risk to oral cancer and is a modifier of the age at oral cancer onset in women above the age of 55 years. Elsevier 2009 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2381/1/MDM2_SNP309_does_not_confer_an_increased_risk_to_oral_squamous_cell_carcinoma_but_may_modulate_the_age_of_disease_onset.pdf application/pdf en http://eprints.um.edu.my/2381/2/MDM2.pdf Zain , R.B. and Hamid, S. and Yang, YH and Peng, K. N. L. and Ismail, S.M. and Lim, K. P. and Wan Mustafa, W. M. and Abraham, M. T. and Teo, S.H. and Cheong, S.C. (2009) MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset. Oral Oncology, 45 (6). pp. 496-500. ISSN 1368-8375 , DOI https://doi.org/10.1016/j.oraloncology.2008.06.003 <https://doi.org/10.1016/j.oraloncology.2008.06.003>. 10.1016/j.oraloncology.2008.06.003 |
| spellingShingle | R Medicine RD Surgery RK Dentistry Oral surger Zain , R.B. Hamid, S. Yang, YH Peng, K. N. L. Ismail, S.M. Lim, K. P. Wan Mustafa, W. M. Abraham, M. T. Teo, S.H. Cheong, S.C. MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset |
| title | MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset |
| title_full | MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset |
| title_fullStr | MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset |
| title_full_unstemmed | MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset |
| title_short | MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset |
| title_sort | mdm2 snp309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset |
| topic | R Medicine RD Surgery RK Dentistry Oral surger |
| url | http://eprints.um.edu.my/2381/1/MDM2_SNP309_does_not_confer_an_increased_risk_to_oral_squamous_cell_carcinoma_but_may_modulate_the_age_of_disease_onset.pdf http://eprints.um.edu.my/2381/2/MDM2.pdf |
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