Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study
Background Nasal lavage with mupirocin has the potential to reduce sinonasal morbidity in endoscopic endonasal approaches for skull base surgery.Objective To evaluate the effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery.Methods A pilot randomised, cont...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Published: |
Royal Society of Medicine
2019
|
| Subjects: |
| _version_ | 1825722139602321408 |
|---|---|
| author | Ng, Boon Han Kevin Tang, Ing Ping Narayanan, Prepageran Raman, Rajagopalan Carrau, Ricardo Luis |
| author_facet | Ng, Boon Han Kevin Tang, Ing Ping Narayanan, Prepageran Raman, Rajagopalan Carrau, Ricardo Luis |
| author_sort | Ng, Boon Han Kevin |
| collection | UM |
| description | Background Nasal lavage with mupirocin has the potential to reduce sinonasal morbidity in endoscopic endonasal approaches for skull base surgery.Objective To evaluate the effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery.Methods A pilot randomised, controlled trial was conducted on 20 adult patients who had undergone endoscopic endonasal approaches for skull base lesions. These patients were randomly assigned to cohorts using nasal lavages with mupirocin or without mupirocin. Patients were assessed in the out-patient clinic, one week and one month after surgery, using the 22-item Sino-Nasal Outcome Test questionnaire and nasal endoscopy.Results Patients in the mupirocin nasal lavage group had lower nasal endoscopy scores post-operatively, and a statistically significant larger difference in nasal endoscopy scores at one month compared to one week. The mupirocin nasal lavage group also showed better Sino-Nasal Outcome Test scores at one month compared to the group without mupirocin.Conclusion Nasal lavage with mupirocin seems to yield better outcomes regarding patients' symptoms and endoscopic findings. © Copyright JLO (1984) Limited, 2019. |
| first_indexed | 2024-03-06T06:01:05Z |
| format | Article |
| id | um.eprints-23859 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T06:01:05Z |
| publishDate | 2019 |
| publisher | Royal Society of Medicine |
| record_format | dspace |
| spelling | um.eprints-238592020-02-20T01:53:09Z http://eprints.um.edu.my/23859/ Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study Ng, Boon Han Kevin Tang, Ing Ping Narayanan, Prepageran Raman, Rajagopalan Carrau, Ricardo Luis R Medicine RF Otorhinolaryngology Background Nasal lavage with mupirocin has the potential to reduce sinonasal morbidity in endoscopic endonasal approaches for skull base surgery.Objective To evaluate the effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery.Methods A pilot randomised, controlled trial was conducted on 20 adult patients who had undergone endoscopic endonasal approaches for skull base lesions. These patients were randomly assigned to cohorts using nasal lavages with mupirocin or without mupirocin. Patients were assessed in the out-patient clinic, one week and one month after surgery, using the 22-item Sino-Nasal Outcome Test questionnaire and nasal endoscopy.Results Patients in the mupirocin nasal lavage group had lower nasal endoscopy scores post-operatively, and a statistically significant larger difference in nasal endoscopy scores at one month compared to one week. The mupirocin nasal lavage group also showed better Sino-Nasal Outcome Test scores at one month compared to the group without mupirocin.Conclusion Nasal lavage with mupirocin seems to yield better outcomes regarding patients' symptoms and endoscopic findings. © Copyright JLO (1984) Limited, 2019. Royal Society of Medicine 2019 Article PeerReviewed Ng, Boon Han Kevin and Tang, Ing Ping and Narayanan, Prepageran and Raman, Rajagopalan and Carrau, Ricardo Luis (2019) Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study. The Journal of Laryngology & Otology, 133 (12). pp. 1059-1063. ISSN 0022-2151, DOI https://doi.org/10.1017/S0022215119002329 <https://doi.org/10.1017/S0022215119002329>. https://doi.org/10.1017/S0022215119002329 doi:10.1017/S0022215119002329 |
| spellingShingle | R Medicine RF Otorhinolaryngology Ng, Boon Han Kevin Tang, Ing Ping Narayanan, Prepageran Raman, Rajagopalan Carrau, Ricardo Luis Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study |
| title | Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study |
| title_full | Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study |
| title_fullStr | Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study |
| title_full_unstemmed | Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study |
| title_short | Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study |
| title_sort | effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery a randomised controlled study |
| topic | R Medicine RF Otorhinolaryngology |
| work_keys_str_mv | AT ngboonhankevin effectsofnasallavagewithandwithoutmupirocinafterendoscopicendonasalskullbasesurgeryarandomisedcontrolledstudy AT tangingping effectsofnasallavagewithandwithoutmupirocinafterendoscopicendonasalskullbasesurgeryarandomisedcontrolledstudy AT narayananprepageran effectsofnasallavagewithandwithoutmupirocinafterendoscopicendonasalskullbasesurgeryarandomisedcontrolledstudy AT ramanrajagopalan effectsofnasallavagewithandwithoutmupirocinafterendoscopicendonasalskullbasesurgeryarandomisedcontrolledstudy AT carrauricardoluis effectsofnasallavagewithandwithoutmupirocinafterendoscopicendonasalskullbasesurgeryarandomisedcontrolledstudy |