Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies
The antipyretic potential of viscosine, a natural product isolated from the medicinal plant Dodonaea viscosa, was investigated using yeast-induced pyrexia rat model, and its structure-activity relationship was investigated through molecular docking analyses with the target enzymes cyclooxygenase-1 (...
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American Chemical Society
2019
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| author | Muhammad, Akhtar Khan, Behramand Iqbal, Zafar Khan, Amir Zada Khan, Inamullah Khan, Kashif Alamzeb, Muhammad Ahmad, Nasir Khan, Khalid Lal Badshah, Syed Ullah, Asad Muhammad, Sayyar Jan, Muhammad Tariq Nadeem, Said Kabir, Nurul |
| author_facet | Muhammad, Akhtar Khan, Behramand Iqbal, Zafar Khan, Amir Zada Khan, Inamullah Khan, Kashif Alamzeb, Muhammad Ahmad, Nasir Khan, Khalid Lal Badshah, Syed Ullah, Asad Muhammad, Sayyar Jan, Muhammad Tariq Nadeem, Said Kabir, Nurul |
| author_sort | Muhammad, Akhtar |
| collection | UM |
| description | The antipyretic potential of viscosine, a natural product isolated from the medicinal plant Dodonaea viscosa, was investigated using yeast-induced pyrexia rat model, and its structure-activity relationship was investigated through molecular docking analyses with the target enzymes cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1). The in vivo antipyretic experiments showed a progressive dose-dependent reduction in body temperatures of the hyperthermic test animals when injected with viscosine. Comparison of docking analyses with target enzymes showed strongest bonding interactions (binding energy -17.34 kcal/mol) of viscosine with the active-site pocket of mPGES-1. These findings suggest that viscosine shows antipyretic properties by reducing the concentration of prostaglandin E2 in brain through its mPGES-1 inhibitory action and make it a potential lead compound for developing effective and safer antipyretic drugs for treating fever and related pathological conditions. Copyright © 2019 American Chemical Society. |
| first_indexed | 2024-03-06T06:01:21Z |
| format | Article |
| id | um.eprints-23951 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T06:01:21Z |
| publishDate | 2019 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | um.eprints-239512020-03-04T02:22:20Z http://eprints.um.edu.my/23951/ Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies Muhammad, Akhtar Khan, Behramand Iqbal, Zafar Khan, Amir Zada Khan, Inamullah Khan, Kashif Alamzeb, Muhammad Ahmad, Nasir Khan, Khalid Lal Badshah, Syed Ullah, Asad Muhammad, Sayyar Jan, Muhammad Tariq Nadeem, Said Kabir, Nurul Q Science (General) QD Chemistry QH Natural history The antipyretic potential of viscosine, a natural product isolated from the medicinal plant Dodonaea viscosa, was investigated using yeast-induced pyrexia rat model, and its structure-activity relationship was investigated through molecular docking analyses with the target enzymes cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1). The in vivo antipyretic experiments showed a progressive dose-dependent reduction in body temperatures of the hyperthermic test animals when injected with viscosine. Comparison of docking analyses with target enzymes showed strongest bonding interactions (binding energy -17.34 kcal/mol) of viscosine with the active-site pocket of mPGES-1. These findings suggest that viscosine shows antipyretic properties by reducing the concentration of prostaglandin E2 in brain through its mPGES-1 inhibitory action and make it a potential lead compound for developing effective and safer antipyretic drugs for treating fever and related pathological conditions. Copyright © 2019 American Chemical Society. American Chemical Society 2019 Article PeerReviewed Muhammad, Akhtar and Khan, Behramand and Iqbal, Zafar and Khan, Amir Zada and Khan, Inamullah and Khan, Kashif and Alamzeb, Muhammad and Ahmad, Nasir and Khan, Khalid and Lal Badshah, Syed and Ullah, Asad and Muhammad, Sayyar and Jan, Muhammad Tariq and Nadeem, Said and Kabir, Nurul (2019) Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies. ACS Omega, 4 (10). pp. 14188-14192. ISSN 2470-1343, DOI https://doi.org/10.1021/acsomega.9b01041 <https://doi.org/10.1021/acsomega.9b01041>. https://doi.org/10.1021/acsomega.9b01041 doi:10.1021/acsomega.9b01041 |
| spellingShingle | Q Science (General) QD Chemistry QH Natural history Muhammad, Akhtar Khan, Behramand Iqbal, Zafar Khan, Amir Zada Khan, Inamullah Khan, Kashif Alamzeb, Muhammad Ahmad, Nasir Khan, Khalid Lal Badshah, Syed Ullah, Asad Muhammad, Sayyar Jan, Muhammad Tariq Nadeem, Said Kabir, Nurul Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies |
| title | Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies |
| title_full | Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies |
| title_fullStr | Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies |
| title_full_unstemmed | Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies |
| title_short | Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies |
| title_sort | viscosine as a potent and safe antipyretic agent evaluated by yeast induced pyrexia model and molecular docking studies |
| topic | Q Science (General) QD Chemistry QH Natural history |
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