Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition

Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition

Clerodendron capitatum (Willd) (family: verbenaceae) is locally named as Gung and used traditionally to treat erectile dysfunction.Therefore, the current study was designed to investigate the erectogenic properties of C. capitatum. The relaxation eﬀect of this plant was tested on phenylephrine prec...

Full description

Bibliographic Details
Main Authors:	Abdelwahab, S.I., Mohamed, A.H., Oall, M., Mohamed, O.Y., Elhassan Taha, M.M., Mohan, S., Noordin, M.I., Mustafa, Mohd Rais, M. Alkharfy, K.
Format:	Article
Language:	English
Published:	Hindawi 2011
Subjects:	R Medicine (General) RM Therapeutics. Pharmacology
Online Access:	http://eprints.um.edu.my/2406/1/Erectogenic_Effects_of_Clerodendron_capitatum.pdf

Similar Items

Serotonergic properties of the roots of Clerodendron capitatum
by: Abdelwahab, Siddig Ibrahim, et al.
Published: (2008)

In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-Ã�ÂºB translocation
by: Abdelwahab, S.I., et al.
Published: (2011)

Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid
by: Ajay, M., et al.
Published: (2007)

Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: comparative study with ascorbic acid
by: Ajay, M., et al.
Published: (2006)

Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta
by: Ajay, M., et al.
Published: (2005)

Effects of ascorbic acid on impaired vascular reactivity in aortas isolated from age-matched hypertensive and diabetic rats
by: Ajay, M., et al.
Published: (2006)

Baicalein impairs vascular tone in normal rat aortas: role of superoxide anions
by: Machha, A., et al.
Published: (2007)

Effects of des-aspartate-angiotensin I on the actions of angiotensin III in the renal and mesenteric vasculature of normo-and hypertensive rats
by: Mustafa, Mohd Rais, et al.
Published: (2004)

Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery
by: Islam, M.M., et al.
Published: (2015)

Effect of acidosis on the mechanism (s) of insulin-induced vasorelaxation in normal Wistar-Kyoto (WKY) rat aorta
by: Subramaniam, G., et al.
Published: (2009)

Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells
by: Lee, S.T., et al.
Published: (2011)

Palm oil tocotrienol fractions restore endothelium dependent relaxation in aortic rings of streptozotocin-induced diabetic and spontaneously hypertensive rats
by: Muharis, S.P., et al.
Published: (2010)

Up Regulation of cystathione γ lyase and Hydrogen Sulphide in the Myocardium Inhibits the Progression of Isoproterenol–Caffeine Induced Left Ventricular Hypertrophy in Wistar Kyoto Rats
by: Ahmad, A., et al.
Published: (2016)

Association of elevated blood pressure and impaired vasorelaxation in experimental Sprague-Dawley rats fed with heated vegetable oil
by: Leong, X.F., et al.
Published: (2010)

Effect of repeatedly heated palm olein on blood pressure regulating enzymes activity and lipid peroxidation in rats
by: Leong, X.F., et al.
Published: (2012)

Effects of ascorbic acid on impaired vascular reactivity in aortas isolated from age-matched hypertensive and diabetic rats
by: Ajay, M., et al.
Published: (2006)

Effects of des-aspartate-angiotensin I on the actions of angiotensin III in the renal and mesenteric vasculature of normo-and hypertensive rats
by: Mustafa, M.R., et al.
Published: (2004)

Reactive oxygen species-induced impairment of endothelium-dependent relaxations in rat aortic rings: protection by methanolic extracts of phoebe grandis
by: Lau, Yeh-Siang, et al.
Published: (2011)

Intake of repeatedly heated palm oil causes elevation in blood pressure with impaired vasorelaxation in rats
by: Leong, Xin Fang, et al.
Published: (2009)

Rhodomyrtus Tomentosa: A Phytochemical and Pharmacological Review
by: Hazrulrizawati, Hamid, et al.
Published: (2017)

Antibacterial Activity of Different Extracts of Swietenia Macrophylla King
by: Azhari, H. Nour, et al.
Published: (2012)

The Personalization of Clopidogrel Antiplatelet Therapy in Coronary Artery Disease Patients using Pharmacometabonomics, Pharmacogenetics and Platelets Function Testing
by: Mostafa, Arwa Mohamed Amin
Published: (2016)

UPLC-QTOF/MS-based phenolic profiling of Melastomaceae, their antioxidant activity and cytotoxic effects against human breast cancer cell MDA-MB-231
by: Hazrulrizawati, Hamid, et al.
Published: (2018)

Inhibition of microlax- Induced experimental diarrhoea with narcotic like-extracts of psidium guajava leaf in rats
by: Lutterodt, George D.
Published: (1999)

Qualitative phytochemical analysis on psidium guajava leaves extracts and its inhibition effects on human osteosarcoma cells
by: Ruslan, Nor Farhana
Published: (2009)

The inhibition of glucose absorption of seed and pericarp extracts of Pithecellobium jiringa on intestinal tissues preparation and their phytochemical profiles
by: Kasmuri, Abdul Razak, et al.
Published: (2010)

Cystathione gamma lyase/Hydrogen Sulphide Pathway Up Regulation Enhances the Responsiveness of α1A and α1B-Adrenoreceptors in the Kidney of Rats with Left Ventricular Hypertrophy
by: Ahmad, A., et al.
Published: (2016)

In vitro and in vivo evaluation of a novel testosterone transdermal delivery system (TTDS) using palm oil base
by: Haron, D.E.M., et al.
Published: (2015)

Comparative Analysis of Antioxidant and Antiproliferative Activities of Rhodomyrtus Tomentosa Extracts Prepared with Various Solvents
by: Hazrulrizawati, Hamid, et al.
Published: (2017)

Interaction between irbesartan, peroxisome proliferator-activated receptor (PPAR-γ), and adiponectin in the regulation of blood pressure and renal function in spontaneously hypertensive rats
by: Afzal, S., et al.
Published: (2016)

Therapeutic community in ASEAN countries: Scope of practice and indicators of effectiveness
by: Mohamed, Mahmood Nazar, et al.
Published: (2005)

Role of O6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O6-alkylating agents
by: Thompson, M. J., et al.
Published: (2000)

Enhanced expression of endothelial nitric oxide synthase in the myocardium ameliorates the progression of left ventricular hypertrophy in L-arginine treated wistar-kyoto rats
by: Ahmad, A., et al.
Published: (2016)

Antiulcerogenic effects of Brassica oleraceae on ethanol-induce gastric ulcer in rats
by: Aymen, A.W., et al.
Published: (2009)

In vivo toxicity study of a plant Phyllanthus amarus, in rat
by: Sirajudeen, K.N.S., et al.
Published: (2005)

Effects of bee bread supplementation on endurance running performance and total antioxidant status in recreational athletes
by: Ping, Fadzel Wong Chee, et al.
Published: (2018)

Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels
by: Khalil, Md. Ibrahim, et al.
Published: (2015)

Downregulation of cystathionine γ lyase and endothelial nitric oxide synthase and reduced responsiveness of α1A adrenergic receptors in the kidneys of left ventricular hypertrophied Wistar Kyoto rats
by: Ahmad, A., et al.
Published: (2016)

Hypoglycemic and antidiabetic activities of Gynura procumbens extract
by: Mohd. Bohari, Siti Pauliena, et al.
Published: (2006)

Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract
by: Khalil, Md. Ibrahim, et al.
Published: (2015)