A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules
The different states of water incorporated in wet granules were studied by a low-field benchtop 1H-NMR time-domain NMR (TD-NMR) instrument. Wet granules consisting different fillers [cornstarch (CS), microcrystalline cellulose (MCC), and D-mannitol (MAN)] with different water contents were prepared...
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| Format: | Article |
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Pharmaceutical Society of Japan
2019
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| _version_ | 1796961953420148736 |
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| author | Ito, Terushi Okada, Kotaro Leong, Kok Hoong Hirai, Daijiro Hayashi, Yoshihiro Kumada, Shungo Kosugi, Atsushi Onuki, Yoshinori |
| author_facet | Ito, Terushi Okada, Kotaro Leong, Kok Hoong Hirai, Daijiro Hayashi, Yoshihiro Kumada, Shungo Kosugi, Atsushi Onuki, Yoshinori |
| author_sort | Ito, Terushi |
| collection | UM |
| description | The different states of water incorporated in wet granules were studied by a low-field benchtop 1H-NMR time-domain NMR (TD-NMR) instrument. Wet granules consisting different fillers [cornstarch (CS), microcrystalline cellulose (MCC), and D-mannitol (MAN)] with different water contents were prepared using a high-speed granulator, and then their spin–spin relaxation time (T2) was measured using the NMR relaxation technique. The experimental T2 relaxation curves were analyzed by the two-component curve fitting, and then the individual T2 relaxation behaviors of solid and water in wet granules were identified. According to the observed T2 values, it was confirmed that the molecular mobility of water in CS and MCC granules was more restricted than that in the MAN granule. The state of water appeared to be associated with the drying efficiency and moisture absorption capacity of wet granules. Thus, it was confirmed that the state of water significantly affected the wet granulation process and the characteristics of the resultant granules. In the final phase of this study, the effects of binders on the molecular mobility of water in granulation fluids and wet granules were examined. The state of water in granulation fluids was substantially changed by changing the binders. The difference was still detected in wet granules prepared by addition of these fluids to the fillers. In conclusion, TD-NMR can offer valuable knowledge on wet granulation from the viewpoint of molecular mobility of water. © 2019 The Pharmaceutical Society of Japan. |
| first_indexed | 2024-03-06T06:01:48Z |
| format | Article |
| id | um.eprints-24102 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T06:01:48Z |
| publishDate | 2019 |
| publisher | Pharmaceutical Society of Japan |
| record_format | dspace |
| spelling | um.eprints-241022020-03-26T04:43:29Z http://eprints.um.edu.my/24102/ A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules Ito, Terushi Okada, Kotaro Leong, Kok Hoong Hirai, Daijiro Hayashi, Yoshihiro Kumada, Shungo Kosugi, Atsushi Onuki, Yoshinori R Medicine RS Pharmacy and materia medica The different states of water incorporated in wet granules were studied by a low-field benchtop 1H-NMR time-domain NMR (TD-NMR) instrument. Wet granules consisting different fillers [cornstarch (CS), microcrystalline cellulose (MCC), and D-mannitol (MAN)] with different water contents were prepared using a high-speed granulator, and then their spin–spin relaxation time (T2) was measured using the NMR relaxation technique. The experimental T2 relaxation curves were analyzed by the two-component curve fitting, and then the individual T2 relaxation behaviors of solid and water in wet granules were identified. According to the observed T2 values, it was confirmed that the molecular mobility of water in CS and MCC granules was more restricted than that in the MAN granule. The state of water appeared to be associated with the drying efficiency and moisture absorption capacity of wet granules. Thus, it was confirmed that the state of water significantly affected the wet granulation process and the characteristics of the resultant granules. In the final phase of this study, the effects of binders on the molecular mobility of water in granulation fluids and wet granules were examined. The state of water in granulation fluids was substantially changed by changing the binders. The difference was still detected in wet granules prepared by addition of these fluids to the fillers. In conclusion, TD-NMR can offer valuable knowledge on wet granulation from the viewpoint of molecular mobility of water. © 2019 The Pharmaceutical Society of Japan. Pharmaceutical Society of Japan 2019 Article PeerReviewed Ito, Terushi and Okada, Kotaro and Leong, Kok Hoong and Hirai, Daijiro and Hayashi, Yoshihiro and Kumada, Shungo and Kosugi, Atsushi and Onuki, Yoshinori (2019) A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules. Chemical and Pharmaceutical Bulletin, 67 (3). pp. 271-276. ISSN 0009-2363, DOI https://doi.org/10.1248/cpb.c18-00888 <https://doi.org/10.1248/cpb.c18-00888>. https://doi.org/10.1248/cpb.c18-00888 doi:10.1248/cpb.c18-00888 |
| spellingShingle | R Medicine RS Pharmacy and materia medica Ito, Terushi Okada, Kotaro Leong, Kok Hoong Hirai, Daijiro Hayashi, Yoshihiro Kumada, Shungo Kosugi, Atsushi Onuki, Yoshinori A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules |
| title | A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules |
| title_full | A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules |
| title_fullStr | A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules |
| title_full_unstemmed | A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules |
| title_short | A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules |
| title_sort | time domain nmr study of the state of water in wet granules with different fillers and its contribution to the wet granulation process and to the characteristics of granules |
| topic | R Medicine RS Pharmacy and materia medica |
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