Validation of the Malay Version of Addenbrooke’s Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia
Background/Aims: This study aimed to investigate the validity and reliability of the Malay version of Addenbrooke's Cognitive Examination III (ACE-III) for detecting mild cognitive impairment (MCI) and dementia. Methods: A total of 152 participants (dementia = 53, MCI = 38, controls = 61) were...
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Karger Publishers Open Access
2019
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| author | Kan, Kwai Ching Subramaniam, Ponnusamy Shahrizaila, Nortina Kamaruzzaman, Shahrul Bahyah Razali, Rosdinom Ghazali, Shazli Ezzat |
| author_facet | Kan, Kwai Ching Subramaniam, Ponnusamy Shahrizaila, Nortina Kamaruzzaman, Shahrul Bahyah Razali, Rosdinom Ghazali, Shazli Ezzat |
| author_sort | Kan, Kwai Ching |
| collection | UM |
| description | Background/Aims: This study aimed to investigate the validity and reliability of the Malay version of Addenbrooke's Cognitive Examination III (ACE-III) for detecting mild cognitive impairment (MCI) and dementia. Methods: A total of 152 participants (dementia = 53, MCI = 38, controls = 61) were recruited from two teaching hospitals. The Malay version of ACE-III was translated following the standard guidelines for cross-cultural adaptation of measure. All the participants were assessed with the Malay version of ACE-III and Mini-Mental State Examination (MMSE). Results: The reliability of the Malay version of ACE-III was good with Cronbach's α coefficient of 0.829 and intraclass correlation coefficient of 0.959. There was a strong positive correlation between the Malay version of ACE-III and MMSE (r = 0.806). Age (r = -0.335) and years of education (r = 0.536) exerted a significant correlation with total score performance. The cutoff score to discriminate dementia from healthy controls was 74/75 (sensitivity = 90.6%, specificity = 82.0%) whereas to discriminate MCI, the cutoff score was 77/78 (sensitivity = 63.2%, specificity = 63.9%). The diagnostic accuracy of ACE-III was higher than that of MMSE in the detection of dementia (area under the curve: ACE-III = 0.929 vs. MMSE = 0.915). Conclusions: The Malay version of ACE-III demonstrated to be a reliable and valid screening tool for dementia. © 2019 The Author(s) Published by S. Karger AG, Basel. |
| first_indexed | 2024-03-06T06:02:02Z |
| format | Article |
| id | um.eprints-24181 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T06:02:02Z |
| publishDate | 2019 |
| publisher | Karger Publishers Open Access |
| record_format | dspace |
| spelling | um.eprints-241812020-04-09T03:48:22Z http://eprints.um.edu.my/24181/ Validation of the Malay Version of Addenbrooke’s Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia Kan, Kwai Ching Subramaniam, Ponnusamy Shahrizaila, Nortina Kamaruzzaman, Shahrul Bahyah Razali, Rosdinom Ghazali, Shazli Ezzat R Medicine Background/Aims: This study aimed to investigate the validity and reliability of the Malay version of Addenbrooke's Cognitive Examination III (ACE-III) for detecting mild cognitive impairment (MCI) and dementia. Methods: A total of 152 participants (dementia = 53, MCI = 38, controls = 61) were recruited from two teaching hospitals. The Malay version of ACE-III was translated following the standard guidelines for cross-cultural adaptation of measure. All the participants were assessed with the Malay version of ACE-III and Mini-Mental State Examination (MMSE). Results: The reliability of the Malay version of ACE-III was good with Cronbach's α coefficient of 0.829 and intraclass correlation coefficient of 0.959. There was a strong positive correlation between the Malay version of ACE-III and MMSE (r = 0.806). Age (r = -0.335) and years of education (r = 0.536) exerted a significant correlation with total score performance. The cutoff score to discriminate dementia from healthy controls was 74/75 (sensitivity = 90.6%, specificity = 82.0%) whereas to discriminate MCI, the cutoff score was 77/78 (sensitivity = 63.2%, specificity = 63.9%). The diagnostic accuracy of ACE-III was higher than that of MMSE in the detection of dementia (area under the curve: ACE-III = 0.929 vs. MMSE = 0.915). Conclusions: The Malay version of ACE-III demonstrated to be a reliable and valid screening tool for dementia. © 2019 The Author(s) Published by S. Karger AG, Basel. Karger Publishers Open Access 2019 Article PeerReviewed Kan, Kwai Ching and Subramaniam, Ponnusamy and Shahrizaila, Nortina and Kamaruzzaman, Shahrul Bahyah and Razali, Rosdinom and Ghazali, Shazli Ezzat (2019) Validation of the Malay Version of Addenbrooke’s Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia. Dementia and Geriatric Cognitive Disorders Extra, 9 (1). pp. 66-76. ISSN 1664-5464, DOI https://doi.org/10.1159/000495107 <https://doi.org/10.1159/000495107>. https://doi.org/10.1159/000495107 doi:10.1159/000495107 |
| spellingShingle | R Medicine Kan, Kwai Ching Subramaniam, Ponnusamy Shahrizaila, Nortina Kamaruzzaman, Shahrul Bahyah Razali, Rosdinom Ghazali, Shazli Ezzat Validation of the Malay Version of Addenbrooke’s Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia |
| title | Validation of the Malay Version of Addenbrooke’s Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia |
| title_full | Validation of the Malay Version of Addenbrooke’s Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia |
| title_fullStr | Validation of the Malay Version of Addenbrooke’s Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia |
| title_full_unstemmed | Validation of the Malay Version of Addenbrooke’s Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia |
| title_short | Validation of the Malay Version of Addenbrooke’s Cognitive Examination III in Detecting Mild Cognitive Impairment and Dementia |
| title_sort | validation of the malay version of addenbrooke s cognitive examination iii in detecting mild cognitive impairment and dementia |
| topic | R Medicine |
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