Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9
Dysregulation of matrix metalloproteinases (MMPs) activity is known in many pathological conditions with which most of the conditions are related to elevate MMPs activities. Ficus deltoidea (FD) is a plant known for its therapeutic properties. In order to evaluate the therapeutic potential of FD lea...
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| Format: | Article |
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Taylor & Francis
2019
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| author | Abu Bakar, Amirul Ridzuan Ripen, Adiratna Mat Merican, Amir Feisal Mohamad, Saharuddin |
| author_facet | Abu Bakar, Amirul Ridzuan Ripen, Adiratna Mat Merican, Amir Feisal Mohamad, Saharuddin |
| author_sort | Abu Bakar, Amirul Ridzuan |
| collection | UM |
| description | Dysregulation of matrix metalloproteinases (MMPs) activity is known in many pathological conditions with which most of the conditions are related to elevate MMPs activities. Ficus deltoidea (FD) is a plant known for its therapeutic properties. In order to evaluate the therapeutic potential of FD leaf extract, we study the enzymatic inhibition properties of FD leaf extract and its major bioactive compounds (vitexin and isovitexin) on a panel of MMPs (MMP-2, MMP-8 and MMP-9) using experimental and computational approaches. FD leaf extract and its major bioactive compounds showed pronounced inhibition activity towards the MMPs tested. Computational docking analysis revealed that vitexin and isovitexin bind to the active site of the three tested MMPs. We also evaluated the cytotoxicity and cell migration inhibition activity of FD leaf extract in the endothelial EA.hy 926 cell line. Conclusively, this study provided additional information on the potential of FD leaf extract for therapeutical application. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. |
| first_indexed | 2024-03-06T06:02:21Z |
| format | Article |
| id | um.eprints-24291 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T06:02:21Z |
| publishDate | 2019 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | um.eprints-242912020-05-18T02:12:44Z http://eprints.um.edu.my/24291/ Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 Abu Bakar, Amirul Ridzuan Ripen, Adiratna Mat Merican, Amir Feisal Mohamad, Saharuddin Q Science (General) QH Natural history Dysregulation of matrix metalloproteinases (MMPs) activity is known in many pathological conditions with which most of the conditions are related to elevate MMPs activities. Ficus deltoidea (FD) is a plant known for its therapeutic properties. In order to evaluate the therapeutic potential of FD leaf extract, we study the enzymatic inhibition properties of FD leaf extract and its major bioactive compounds (vitexin and isovitexin) on a panel of MMPs (MMP-2, MMP-8 and MMP-9) using experimental and computational approaches. FD leaf extract and its major bioactive compounds showed pronounced inhibition activity towards the MMPs tested. Computational docking analysis revealed that vitexin and isovitexin bind to the active site of the three tested MMPs. We also evaluated the cytotoxicity and cell migration inhibition activity of FD leaf extract in the endothelial EA.hy 926 cell line. Conclusively, this study provided additional information on the potential of FD leaf extract for therapeutical application. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Taylor & Francis 2019 Article PeerReviewed Abu Bakar, Amirul Ridzuan and Ripen, Adiratna Mat and Merican, Amir Feisal and Mohamad, Saharuddin (2019) Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9. Natural Product Research, 33 (12). pp. 1765-1768. ISSN 1478-6419, DOI https://doi.org/10.1080/14786419.2018.1434631 <https://doi.org/10.1080/14786419.2018.1434631>. https://doi.org/10.1080/14786419.2018.1434631 doi:10.1080/14786419.2018.1434631 |
| spellingShingle | Q Science (General) QH Natural history Abu Bakar, Amirul Ridzuan Ripen, Adiratna Mat Merican, Amir Feisal Mohamad, Saharuddin Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 |
| title | Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 |
| title_full | Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 |
| title_fullStr | Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 |
| title_full_unstemmed | Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 |
| title_short | Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 |
| title_sort | enzymatic inhibitory activity of ficus deltoidea leaf extract on matrix metalloproteinase 2 8 and 9 |
| topic | Q Science (General) QH Natural history |
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