Cisplatin and vinorelbine in the treatment of locally advanced and metastatic non-small cell lung cancer
From August 1999 to January 2001, twelve chemotherapy naive patients with locally advanced and metastatic non-small cell lung cancer (NSCLC) in our hospital received vinorelbine and cisplatin. Ten patients had stage IV disease while two had stage III disease. Patients' performance status (PS) w...
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| Format: | Article |
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Faculty of Medicine, University of Malaya
2001
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| _version_ | 1825722260113063936 |
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| author | Wong, Catherine Mee Ming Lim, Kim Huat Liam, Chong Kin |
| author_facet | Wong, Catherine Mee Ming Lim, Kim Huat Liam, Chong Kin |
| author_sort | Wong, Catherine Mee Ming |
| collection | UM |
| description | From August 1999 to January 2001, twelve chemotherapy naive patients with locally advanced and metastatic non-small cell lung cancer (NSCLC) in our hospital received vinorelbine and cisplatin. Ten patients had stage IV disease while two had stage III disease. Patients' performance status (PS) were as follows: four had PS 1, six had PS 2, and one each PS 3 and 4. A total of 46 cycles were given as scheduled.
Only major haematological toxicities were noted; one patient each with Grade 3 anaemia, Grade 3 and Grade 4 leucopenia, two had Grade 3 neutropenia and 5 had Grade 4 neutropenia without associated mortality. Three patients had Grade 3 alopecia and one had Grade 3 phlebitis.After Three cycles, three patients demonstrated partial response and two had stable disease. For the four patients who completed 6 cycles, two demonstrated stable disease and two partial response. Symptom improvement was reported in all but one patient. Performance status was better in four, stable in six but declined in two patients. in patients with locally advanced and metastatic NSCLC, vinorelbine/cisplatin is a well-tolerated and active regimen, offering symptom palliation and improved performance status in a significant proportion of patients. |
| first_indexed | 2024-03-06T06:02:57Z |
| format | Article |
| id | um.eprints-24502 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T06:02:57Z |
| publishDate | 2001 |
| publisher | Faculty of Medicine, University of Malaya |
| record_format | dspace |
| spelling | um.eprints-245022021-03-23T05:09:46Z http://eprints.um.edu.my/24502/ Cisplatin and vinorelbine in the treatment of locally advanced and metastatic non-small cell lung cancer Wong, Catherine Mee Ming Lim, Kim Huat Liam, Chong Kin R Medicine From August 1999 to January 2001, twelve chemotherapy naive patients with locally advanced and metastatic non-small cell lung cancer (NSCLC) in our hospital received vinorelbine and cisplatin. Ten patients had stage IV disease while two had stage III disease. Patients' performance status (PS) were as follows: four had PS 1, six had PS 2, and one each PS 3 and 4. A total of 46 cycles were given as scheduled. Only major haematological toxicities were noted; one patient each with Grade 3 anaemia, Grade 3 and Grade 4 leucopenia, two had Grade 3 neutropenia and 5 had Grade 4 neutropenia without associated mortality. Three patients had Grade 3 alopecia and one had Grade 3 phlebitis.After Three cycles, three patients demonstrated partial response and two had stable disease. For the four patients who completed 6 cycles, two demonstrated stable disease and two partial response. Symptom improvement was reported in all but one patient. Performance status was better in four, stable in six but declined in two patients. in patients with locally advanced and metastatic NSCLC, vinorelbine/cisplatin is a well-tolerated and active regimen, offering symptom palliation and improved performance status in a significant proportion of patients. Faculty of Medicine, University of Malaya 2001 Article PeerReviewed Wong, Catherine Mee Ming and Lim, Kim Huat and Liam, Chong Kin (2001) Cisplatin and vinorelbine in the treatment of locally advanced and metastatic non-small cell lung cancer. Journal of the University of Malaya Medical Centre (JUMMEC), 6 (1). pp. 20-23. ISSN 1823-7339, https://jummec.um.edu.my/issue/view/713/Vol.6%2C%20Issue%201%2C%202001 |
| spellingShingle | R Medicine Wong, Catherine Mee Ming Lim, Kim Huat Liam, Chong Kin Cisplatin and vinorelbine in the treatment of locally advanced and metastatic non-small cell lung cancer |
| title | Cisplatin and vinorelbine in the treatment of locally advanced and metastatic non-small cell lung cancer |
| title_full | Cisplatin and vinorelbine in the treatment of locally advanced and metastatic non-small cell lung cancer |
| title_fullStr | Cisplatin and vinorelbine in the treatment of locally advanced and metastatic non-small cell lung cancer |
| title_full_unstemmed | Cisplatin and vinorelbine in the treatment of locally advanced and metastatic non-small cell lung cancer |
| title_short | Cisplatin and vinorelbine in the treatment of locally advanced and metastatic non-small cell lung cancer |
| title_sort | cisplatin and vinorelbine in the treatment of locally advanced and metastatic non small cell lung cancer |
| topic | R Medicine |
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