Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata
The bark extract of Melicope subunifoliolata (Stapf) T.G. Hartley showed competitive muscarinic receptor binding activity. Six polymethoxyflavones [melibentin (1);melisimplexin(3);3,30,40,5,7pentamethoxyflavone(4);melite rnatin (5); 3,5,8-trimethoxy-30,40,6,7 bismethylenedioxyflavone (6); and isokanugi...
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| Format: | Article |
| Language: | English |
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Elsevier
2008
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| Online Access: | http://eprints.um.edu.my/2453/1/Muscarinic_receptor_binding_activity_of_polyoxygenated_flavones_from_Melicope_subunifoliolata.pdf |
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| author | Chung, L.Y. Yap, K.F. Mustafa, Mohd Rais Goh, S.H. Imiyabir, Z. |
| author_facet | Chung, L.Y. Yap, K.F. Mustafa, Mohd Rais Goh, S.H. Imiyabir, Z. |
| author_sort | Chung, L.Y. |
| collection | UM |
| description | The bark extract of Melicope subunifoliolata (Stapf) T.G. Hartley showed competitive muscarinic receptor binding activity. Six polymethoxyflavones [melibentin (1);melisimplexin(3);3,30,40,5,7pentamethoxyflavone(4);melite rnatin (5); 3,5,8-trimethoxy-30,40,6,7 bismethylenedioxyflavone (6); and isokanugin (7)] and one furanocoumarin [5-methoxy-8-geranyloxypsoralen (2)]were isolated fromthe bark extract. Compounds 2 and 6 were isolated for the first time from M. subunifoliolata. Themethoxyflavones (compounds 1, 3,
4, 5, 6, and 7) show moderate inhibition in a muscarinic receptor binding assay, while the furanocoumarin (compound 2) is inactive.
The potency of the methoxyflavones to inhibit [
3
H]NMS-muscarinic receptor binding is influenced by the position and number of methoxy substitution. The results suggest these compounds are probably muscarinic modulators, agonists or partial agonists/antagonists. |
| first_indexed | 2024-03-06T05:08:06Z |
| format | Article |
| id | um.eprints-2453 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:08:06Z |
| publishDate | 2008 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-24532019-12-18T06:25:40Z http://eprints.um.edu.my/2453/ Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata Chung, L.Y. Yap, K.F. Mustafa, Mohd Rais Goh, S.H. Imiyabir, Z. QD Chemistry R Medicine The bark extract of Melicope subunifoliolata (Stapf) T.G. Hartley showed competitive muscarinic receptor binding activity. Six polymethoxyflavones [melibentin (1);melisimplexin(3);3,30,40,5,7pentamethoxyflavone(4);melite rnatin (5); 3,5,8-trimethoxy-30,40,6,7 bismethylenedioxyflavone (6); and isokanugin (7)] and one furanocoumarin [5-methoxy-8-geranyloxypsoralen (2)]were isolated fromthe bark extract. Compounds 2 and 6 were isolated for the first time from M. subunifoliolata. Themethoxyflavones (compounds 1, 3, 4, 5, 6, and 7) show moderate inhibition in a muscarinic receptor binding assay, while the furanocoumarin (compound 2) is inactive. The potency of the methoxyflavones to inhibit [ 3 H]NMS-muscarinic receptor binding is influenced by the position and number of methoxy substitution. The results suggest these compounds are probably muscarinic modulators, agonists or partial agonists/antagonists. Elsevier 2008-03-10 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2453/1/Muscarinic_receptor_binding_activity_of_polyoxygenated_flavones_from_Melicope_subunifoliolata.pdf Chung, L.Y. and Yap, K.F. and Mustafa, Mohd Rais and Goh, S.H. and Imiyabir, Z. (2008) Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata. Phytochemistry, 69 (7). pp. 1548-1554. ISSN 0031-9422, DOI https://doi.org/10.1016/j.phytochem.2008.01.024 <https://doi.org/10.1016/j.phytochem.2008.01.024>. doi:10.1016/j.phytochem.2008.01.024 |
| spellingShingle | QD Chemistry R Medicine Chung, L.Y. Yap, K.F. Mustafa, Mohd Rais Goh, S.H. Imiyabir, Z. Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata |
| title | Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata |
| title_full | Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata |
| title_fullStr | Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata |
| title_full_unstemmed | Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata |
| title_short | Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata |
| title_sort | muscarinic receptor binding activity of polyoxygenated flavones from melicope subunifoliolata |
| topic | QD Chemistry R Medicine |
| url | http://eprints.um.edu.my/2453/1/Muscarinic_receptor_binding_activity_of_polyoxygenated_flavones_from_Melicope_subunifoliolata.pdf |
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