The pattern of CD15, CD30 and Bcl-2 expression in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is a heterogenous entity. The pattern of CD15, CD30 and Bcl-2 expression is not well documented, especially in local population. We investigated 67 consecutive cases of DLBCL by immunohistochemistry on paraffin-embedded tissue. The male to female ratio was 1.2:1...
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| Format: | Article |
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Malaysian Medical Association
2006
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| _version_ | 1796962038860218368 |
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| author | Eow, G.I. Kim, L.H. Peh, S.C. |
| author_facet | Eow, G.I. Kim, L.H. Peh, S.C. |
| author_sort | Eow, G.I. |
| collection | UM |
| description | Diffuse large B-cell lymphoma (DLBCL) is a heterogenous entity. The pattern of CD15, CD30 and Bcl-2 expression is not well documented, especially in local population. We investigated 67 consecutive cases of DLBCL by immunohistochemistry on paraffin-embedded tissue. The male to female ratio was 1.2:1 with median age of 55 years, and more common nodal than extranodal in presentation. Only 3 of 67 cases expressed CD15. In addition, three cases showed weak membrane staining for CD30. Only one of these three cases was noted to have co-expression of CD15 and with occasional tumour cells showing weak CD30 expression. Bcl-2 protein was expressed in 43 of 67 (64%), more frequently in nodal than in extranodal tumours. In conclusion, CD15 and CD30 expressions are infrequent in DLBCL, and co-expression is rare. Bcl-2 protein expression is common in DLBCL. |
| first_indexed | 2024-03-06T06:03:05Z |
| format | Article |
| id | um.eprints-24549 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T06:03:05Z |
| publishDate | 2006 |
| publisher | Malaysian Medical Association |
| record_format | dspace |
| spelling | um.eprints-245492021-03-22T04:06:45Z http://eprints.um.edu.my/24549/ The pattern of CD15, CD30 and Bcl-2 expression in diffuse large B-cell lymphoma Eow, G.I. Kim, L.H. Peh, S.C. R Medicine Diffuse large B-cell lymphoma (DLBCL) is a heterogenous entity. The pattern of CD15, CD30 and Bcl-2 expression is not well documented, especially in local population. We investigated 67 consecutive cases of DLBCL by immunohistochemistry on paraffin-embedded tissue. The male to female ratio was 1.2:1 with median age of 55 years, and more common nodal than extranodal in presentation. Only 3 of 67 cases expressed CD15. In addition, three cases showed weak membrane staining for CD30. Only one of these three cases was noted to have co-expression of CD15 and with occasional tumour cells showing weak CD30 expression. Bcl-2 protein was expressed in 43 of 67 (64%), more frequently in nodal than in extranodal tumours. In conclusion, CD15 and CD30 expressions are infrequent in DLBCL, and co-expression is rare. Bcl-2 protein expression is common in DLBCL. Malaysian Medical Association 2006 Article PeerReviewed Eow, G.I. and Kim, L.H. and Peh, S.C. (2006) The pattern of CD15, CD30 and Bcl-2 expression in diffuse large B-cell lymphoma. Medical Journal of Malaysia, 61 (4). pp. 416-421. ISSN 0300-5283, http://www.e-mjm.org/2006/v61n4/Diffuse_Large_B_Cell_Lymphoma.pdf |
| spellingShingle | R Medicine Eow, G.I. Kim, L.H. Peh, S.C. The pattern of CD15, CD30 and Bcl-2 expression in diffuse large B-cell lymphoma |
| title | The pattern of CD15, CD30 and Bcl-2 expression in diffuse large B-cell lymphoma |
| title_full | The pattern of CD15, CD30 and Bcl-2 expression in diffuse large B-cell lymphoma |
| title_fullStr | The pattern of CD15, CD30 and Bcl-2 expression in diffuse large B-cell lymphoma |
| title_full_unstemmed | The pattern of CD15, CD30 and Bcl-2 expression in diffuse large B-cell lymphoma |
| title_short | The pattern of CD15, CD30 and Bcl-2 expression in diffuse large B-cell lymphoma |
| title_sort | pattern of cd15 cd30 and bcl 2 expression in diffuse large b cell lymphoma |
| topic | R Medicine |
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