Lipoxygenase inhibiting activity of some Malaysian plants
In this study 160 plant samples representing more than 30 plant families collected from the Malaysian forests were assessed for their ability to inhibit lipoxygenase activity. The lipoxygenase inhibiting activity was measured using the 96-well microplate-based ferric oxidation of xylenol orange (FOX...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2009
|
| Subjects: | |
| Online Access: | http://eprints.um.edu.my/2455/1/Lipoxygenase_inhibiting_activity_of_some_Malaysian_plants.pdf |
| _version_ | 1825718681084100608 |
|---|---|
| author | Chung, L.Y. Soo, W.K. Chan, K.Y. Mustafa, Mohd Rais Goh, S.H. Imiyabir, Z. |
| author_facet | Chung, L.Y. Soo, W.K. Chan, K.Y. Mustafa, Mohd Rais Goh, S.H. Imiyabir, Z. |
| author_sort | Chung, L.Y. |
| collection | UM |
| description | In this study 160 plant samples representing more than 30 plant families collected from the Malaysian forests were assessed for their ability to inhibit lipoxygenase activity. The lipoxygenase inhibiting activity was measured using the 96-well microplate-based ferric oxidation of xylenol orange (FOX) assay. The screening parameters, including z’ factor, indicated that the assay method adopted was robust and suitable for highthroughput screening. In the preliminary screen, four plant extracts displayed inhibitory activity of 70% or higher. The active plant extracts were isolated from Agelaea borneensis Merr. (Connaraceae) (bark) (IC
50,1.6 μg/mL), Chisocheton polyandrus Merr. (Meliaceae (bark) (3 μg/mL), Garcinia cuspidata King (Guttiferae)
(bark) (28.3 μg/mL) and Timonius flavescens Baker (Rubiaceae) (leaf) (8.9 μg/mL). |
| first_indexed | 2024-03-06T05:08:06Z |
| format | Article |
| id | um.eprints-2455 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:08:06Z |
| publishDate | 2009 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | um.eprints-24552019-12-18T06:27:01Z http://eprints.um.edu.my/2455/ Lipoxygenase inhibiting activity of some Malaysian plants Chung, L.Y. Soo, W.K. Chan, K.Y. Mustafa, Mohd Rais Goh, S.H. Imiyabir, Z. R Medicine S Agriculture (General) In this study 160 plant samples representing more than 30 plant families collected from the Malaysian forests were assessed for their ability to inhibit lipoxygenase activity. The lipoxygenase inhibiting activity was measured using the 96-well microplate-based ferric oxidation of xylenol orange (FOX) assay. The screening parameters, including z’ factor, indicated that the assay method adopted was robust and suitable for highthroughput screening. In the preliminary screen, four plant extracts displayed inhibitory activity of 70% or higher. The active plant extracts were isolated from Agelaea borneensis Merr. (Connaraceae) (bark) (IC 50,1.6 μg/mL), Chisocheton polyandrus Merr. (Meliaceae (bark) (3 μg/mL), Garcinia cuspidata King (Guttiferae) (bark) (28.3 μg/mL) and Timonius flavescens Baker (Rubiaceae) (leaf) (8.9 μg/mL). Taylor & Francis 2009 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2455/1/Lipoxygenase_inhibiting_activity_of_some_Malaysian_plants.pdf Chung, L.Y. and Soo, W.K. and Chan, K.Y. and Mustafa, Mohd Rais and Goh, S.H. and Imiyabir, Z. (2009) Lipoxygenase inhibiting activity of some Malaysian plants. Pharmaceutical Biology, 47 (12). pp. 1142-1148. ISSN 1388-0209, |
| spellingShingle | R Medicine S Agriculture (General) Chung, L.Y. Soo, W.K. Chan, K.Y. Mustafa, Mohd Rais Goh, S.H. Imiyabir, Z. Lipoxygenase inhibiting activity of some Malaysian plants |
| title | Lipoxygenase inhibiting activity of some Malaysian plants |
| title_full | Lipoxygenase inhibiting activity of some Malaysian plants |
| title_fullStr | Lipoxygenase inhibiting activity of some Malaysian plants |
| title_full_unstemmed | Lipoxygenase inhibiting activity of some Malaysian plants |
| title_short | Lipoxygenase inhibiting activity of some Malaysian plants |
| title_sort | lipoxygenase inhibiting activity of some malaysian plants |
| topic | R Medicine S Agriculture (General) |
| url | http://eprints.um.edu.my/2455/1/Lipoxygenase_inhibiting_activity_of_some_Malaysian_plants.pdf |
| work_keys_str_mv | AT chungly lipoxygenaseinhibitingactivityofsomemalaysianplants AT soowk lipoxygenaseinhibitingactivityofsomemalaysianplants AT chanky lipoxygenaseinhibitingactivityofsomemalaysianplants AT mustafamohdrais lipoxygenaseinhibitingactivityofsomemalaysianplants AT gohsh lipoxygenaseinhibitingactivityofsomemalaysianplants AT imiyabirz lipoxygenaseinhibitingactivityofsomemalaysianplants |