Synchronous adenocarcinoma of caecum, transverse colon and jejunum
Synchronous cancers are defined as malignant tumours that occur simultaneously, each of which must be distinct with no possibility of one being the metastasis of the other. A 65 year old gentleman presented to us with two month history of epigastric pain associated with anaemia, loss of appetite and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Malaysian Medical Association
2008
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| Online Access: | http://eprints.um.edu.my/24594/1/Synchronous_Adenocarcinoma.pdf |
| _version_ | 1825722277745917952 |
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| author | Leong, Benjamin Dak Keung Ramu, P. Kumar, V.M. Chuah, J.A. |
| author_facet | Leong, Benjamin Dak Keung Ramu, P. Kumar, V.M. Chuah, J.A. |
| author_sort | Leong, Benjamin Dak Keung |
| collection | UM |
| description | Synchronous cancers are defined as malignant tumours that occur simultaneously, each of which must be distinct with no possibility of one being the metastasis of the other. A 65 year old gentleman presented to us with two month history of epigastric pain associated with anaemia, loss of appetite and weight. He has no history of malignancy in his family. Colonoscopy revealed tumours at transverse colon and caecum. Intra-operatively, tumours were sited at caecum, transverse colon and jejunum. Tumours were diagnosed as synchronous adenocarcinoma histopathologically with loss of expression of MLH1 and MSH2. From literature search, this is the first reported triple synchronous tumours of the caecum, transverse colon and jejunum. We believe that this gentleman developed triple synchronous tumour through the sporadic MSI pathway. |
| first_indexed | 2024-03-06T06:03:13Z |
| format | Article |
| id | um.eprints-24594 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T06:03:13Z |
| publishDate | 2008 |
| publisher | Malaysian Medical Association |
| record_format | dspace |
| spelling | um.eprints-245942020-06-03T06:42:34Z http://eprints.um.edu.my/24594/ Synchronous adenocarcinoma of caecum, transverse colon and jejunum Leong, Benjamin Dak Keung Ramu, P. Kumar, V.M. Chuah, J.A. R Medicine Synchronous cancers are defined as malignant tumours that occur simultaneously, each of which must be distinct with no possibility of one being the metastasis of the other. A 65 year old gentleman presented to us with two month history of epigastric pain associated with anaemia, loss of appetite and weight. He has no history of malignancy in his family. Colonoscopy revealed tumours at transverse colon and caecum. Intra-operatively, tumours were sited at caecum, transverse colon and jejunum. Tumours were diagnosed as synchronous adenocarcinoma histopathologically with loss of expression of MLH1 and MSH2. From literature search, this is the first reported triple synchronous tumours of the caecum, transverse colon and jejunum. We believe that this gentleman developed triple synchronous tumour through the sporadic MSI pathway. Malaysian Medical Association 2008 Article PeerReviewed text en http://eprints.um.edu.my/24594/1/Synchronous_Adenocarcinoma.pdf Leong, Benjamin Dak Keung and Ramu, P. and Kumar, V.M. and Chuah, J.A. (2008) Synchronous adenocarcinoma of caecum, transverse colon and jejunum. Medical Journal of Malaysia, 63 (2). pp. 148-149. ISSN 0300-5283, http://www.e-mjm.org/2008/v63n2/Synchronous_Adenocarcinoma.pdf |
| spellingShingle | R Medicine Leong, Benjamin Dak Keung Ramu, P. Kumar, V.M. Chuah, J.A. Synchronous adenocarcinoma of caecum, transverse colon and jejunum |
| title | Synchronous adenocarcinoma of caecum, transverse colon and jejunum |
| title_full | Synchronous adenocarcinoma of caecum, transverse colon and jejunum |
| title_fullStr | Synchronous adenocarcinoma of caecum, transverse colon and jejunum |
| title_full_unstemmed | Synchronous adenocarcinoma of caecum, transverse colon and jejunum |
| title_short | Synchronous adenocarcinoma of caecum, transverse colon and jejunum |
| title_sort | synchronous adenocarcinoma of caecum transverse colon and jejunum |
| topic | R Medicine |
| url | http://eprints.um.edu.my/24594/1/Synchronous_Adenocarcinoma.pdf |
| work_keys_str_mv | AT leongbenjamindakkeung synchronousadenocarcinomaofcaecumtransversecolonandjejunum AT ramup synchronousadenocarcinomaofcaecumtransversecolonandjejunum AT kumarvm synchronousadenocarcinomaofcaecumtransversecolonandjejunum AT chuahja synchronousadenocarcinomaofcaecumtransversecolonandjejunum |