Development of small molecule inhibitors targeting TGF-β ligand and receptor: Structures, mechanism, preclinical studies and clinical usage
Transforming growth factor-β (TGF-β) is a member of a superfamily of pleiotropic proteins that regulate multiple cellular processes such as growth, development and differentiation. Following binding to type I and II TGF-β serine/threonine kinase receptors, TGF-β activates downstream signaling cascad...
| Principais autores: | , , , , , , , |
|---|---|
| Formato: | Artigo |
| Publicado em: |
Elsevier
2020
|
| Assuntos: |