Inapparent dengue in a community living among dengue-positive Aedes mosquitoes and in a hospital in Klang Valley, Malaysia
The public health burden of dengue is most likely under reported. Current dengue control measures only considered symptomatic dengue transmission. Hence, there is a paucity of information on the epidemiology of inapparent dengue. This study reports that many people have been unknowingly exposed to d...
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| Format: | Article |
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Elsevier
2020
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| _version_ | 1825722319818981376 |
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| author | Tan, Wing Liew, Jonathan Wee Kent Selvarajoo, Sivaneswari Lim, Xin Ying Foo, Chuan Jie Refai, Wardha F. Robson, Noor Zurani Othman, Sajaratulnisah Abdul Hadi, Haireen Mydin, Fadzilah Hanum Mohd Malik, Tun Firzara Abdul Lau, Yee Ling Vythilingam, Indra |
| author_facet | Tan, Wing Liew, Jonathan Wee Kent Selvarajoo, Sivaneswari Lim, Xin Ying Foo, Chuan Jie Refai, Wardha F. Robson, Noor Zurani Othman, Sajaratulnisah Abdul Hadi, Haireen Mydin, Fadzilah Hanum Mohd Malik, Tun Firzara Abdul Lau, Yee Ling Vythilingam, Indra |
| author_sort | Tan, Wing |
| collection | UM |
| description | The public health burden of dengue is most likely under reported. Current dengue control measures only considered symptomatic dengue transmission. Hence, there is a paucity of information on the epidemiology of inapparent dengue. This study reports that many people have been unknowingly exposed to dengue infection. Almost 10% and 70% of individuals without any history of dengue infection and living in a dengue hotspot, in Selangor, Malaysia, were dengue IgM and IgG positive respectively. When dengue-positive mosquitoes were detected in the hotspot, 11 (6.3%) of the 174 individuals tested were found to have dengue viremia, of which 10 were asymptomatic. Besides, upon detection of a dengue-infected mosquito, transmission was already widespread. In a clinical setting, it appears that people living with dengue patients have been exposed to dengue, whether asymptomatic or symptomatic. They can either have circulating viral RNA and/or presence of NS1 antigen. It is also possible that they are dengue seropositive. Collectively, the results indicate that actions taken to control dengue transmission after the first report of dengue cases may be already too late. The current study also revealed challenges in diagnosing clinically inapparent dengue in hyperendemic settings. There is no one best method for diagnosing inapparent dengue. This study demonstrates empirical evidence of inapparent dengue in different settings. Early dengue surveillance in the mosquito population and active serological/virological surveillance in humans can go hand in hand. More studies are required to investigate the epidemiology, seroprevalence, diagnostics, and control of inapparent dengue. It is also crucial to educate the public, health staff and medical professionals on asymptomatic dengue and to propagate awareness, which is important for controlling transmission. © 2020 Elsevier B.V. |
| first_indexed | 2024-03-06T06:03:52Z |
| format | Article |
| id | um.eprints-24821 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T06:03:52Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-248212020-06-15T02:51:06Z http://eprints.um.edu.my/24821/ Inapparent dengue in a community living among dengue-positive Aedes mosquitoes and in a hospital in Klang Valley, Malaysia Tan, Wing Liew, Jonathan Wee Kent Selvarajoo, Sivaneswari Lim, Xin Ying Foo, Chuan Jie Refai, Wardha F. Robson, Noor Zurani Othman, Sajaratulnisah Abdul Hadi, Haireen Mydin, Fadzilah Hanum Mohd Malik, Tun Firzara Abdul Lau, Yee Ling Vythilingam, Indra R Medicine The public health burden of dengue is most likely under reported. Current dengue control measures only considered symptomatic dengue transmission. Hence, there is a paucity of information on the epidemiology of inapparent dengue. This study reports that many people have been unknowingly exposed to dengue infection. Almost 10% and 70% of individuals without any history of dengue infection and living in a dengue hotspot, in Selangor, Malaysia, were dengue IgM and IgG positive respectively. When dengue-positive mosquitoes were detected in the hotspot, 11 (6.3%) of the 174 individuals tested were found to have dengue viremia, of which 10 were asymptomatic. Besides, upon detection of a dengue-infected mosquito, transmission was already widespread. In a clinical setting, it appears that people living with dengue patients have been exposed to dengue, whether asymptomatic or symptomatic. They can either have circulating viral RNA and/or presence of NS1 antigen. It is also possible that they are dengue seropositive. Collectively, the results indicate that actions taken to control dengue transmission after the first report of dengue cases may be already too late. The current study also revealed challenges in diagnosing clinically inapparent dengue in hyperendemic settings. There is no one best method for diagnosing inapparent dengue. This study demonstrates empirical evidence of inapparent dengue in different settings. Early dengue surveillance in the mosquito population and active serological/virological surveillance in humans can go hand in hand. More studies are required to investigate the epidemiology, seroprevalence, diagnostics, and control of inapparent dengue. It is also crucial to educate the public, health staff and medical professionals on asymptomatic dengue and to propagate awareness, which is important for controlling transmission. © 2020 Elsevier B.V. Elsevier 2020 Article PeerReviewed Tan, Wing and Liew, Jonathan Wee Kent and Selvarajoo, Sivaneswari and Lim, Xin Ying and Foo, Chuan Jie and Refai, Wardha F. and Robson, Noor Zurani and Othman, Sajaratulnisah and Abdul Hadi, Haireen and Mydin, Fadzilah Hanum Mohd and Malik, Tun Firzara Abdul and Lau, Yee Ling and Vythilingam, Indra (2020) Inapparent dengue in a community living among dengue-positive Aedes mosquitoes and in a hospital in Klang Valley, Malaysia. Acta Tropica, 204. p. 105330. ISSN 0001-706X, DOI https://doi.org/10.1016/j.actatropica.2020.105330 <https://doi.org/10.1016/j.actatropica.2020.105330>. https://doi.org/10.1016/j.actatropica.2020.105330 doi:10.1016/j.actatropica.2020.105330 |
| spellingShingle | R Medicine Tan, Wing Liew, Jonathan Wee Kent Selvarajoo, Sivaneswari Lim, Xin Ying Foo, Chuan Jie Refai, Wardha F. Robson, Noor Zurani Othman, Sajaratulnisah Abdul Hadi, Haireen Mydin, Fadzilah Hanum Mohd Malik, Tun Firzara Abdul Lau, Yee Ling Vythilingam, Indra Inapparent dengue in a community living among dengue-positive Aedes mosquitoes and in a hospital in Klang Valley, Malaysia |
| title | Inapparent dengue in a community living among dengue-positive Aedes mosquitoes and in a hospital in Klang Valley, Malaysia |
| title_full | Inapparent dengue in a community living among dengue-positive Aedes mosquitoes and in a hospital in Klang Valley, Malaysia |
| title_fullStr | Inapparent dengue in a community living among dengue-positive Aedes mosquitoes and in a hospital in Klang Valley, Malaysia |
| title_full_unstemmed | Inapparent dengue in a community living among dengue-positive Aedes mosquitoes and in a hospital in Klang Valley, Malaysia |
| title_short | Inapparent dengue in a community living among dengue-positive Aedes mosquitoes and in a hospital in Klang Valley, Malaysia |
| title_sort | inapparent dengue in a community living among dengue positive aedes mosquitoes and in a hospital in klang valley malaysia |
| topic | R Medicine |
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