Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients

The excess accumulation of advanced glycation end products (AGEs) contributes to the chronic complications of type 2 diabetes mellitus (DM) and renal failure. Biopsy specimens (n = 184) of arterial (n = 92) and venous (n = 92) tissues were obtained (radial artery and cephalic vein) from end-stage re...

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Main Authors: Nazratun, N., Mahmood Merican, A., Kuppusamy, U.R., Ahmad, T.S., Tan, S.Y.
Format: Article
Language:English
Published: Arnold Publishers (journals now owned by Sage) 2007
Subjects:
Online Access:http://eprints.um.edu.my/2496/1/Vasc_Med-2006-Nazratun-245-50.pdf
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author Nazratun, N.
Mahmood Merican, A.
Kuppusamy, U.R.
Ahmad, T.S.
Tan, S.Y.
author_facet Nazratun, N.
Mahmood Merican, A.
Kuppusamy, U.R.
Ahmad, T.S.
Tan, S.Y.
author_sort Nazratun, N.
collection UM
description The excess accumulation of advanced glycation end products (AGEs) contributes to the chronic complications of type 2 diabetes mellitus (DM) and renal failure. Biopsy specimens (n = 184) of arterial (n = 92) and venous (n = 92) tissues were obtained (radial artery and cephalic vein) from end-stage renal disease (ESRD) patients with or without DM and normal healthy subjects (n = 12) requiring surgery (trauma patients). Immunohistochemical assessment of the blood vessels revealed the presence of pentosidine (AGE marker) in both veins and arteries in 72% of the ESRD patients. The percentage of arteries and veins that showed positive pentosidine staining in ESRD patients with type 2 DM alone was 100% and 92% respectively, in the non-diabetic ESRD patients it was <70% (for arteries and veins), and in the ESRD patients with hypertension as an additional co-morbidity to type 2 DM it was 70% and 82%, respectively. The veins of ESRD patients with DM showed a strong (+++) positive staining and very strong (++++) positive staining was observed in the patients with DM and hypertension. Only mild (+) or moderate (++) pentosidine staining intensity was observed in the arteries of ESRD patients without or with comorbidities, respectively. The accumulation of AGE in the vein rather than the artery may be a better reflection of the extent of complications of ESRD.
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spelling um.eprints-24962014-10-27T06:57:40Z http://eprints.um.edu.my/2496/ Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients Nazratun, N. Mahmood Merican, A. Kuppusamy, U.R. Ahmad, T.S. Tan, S.Y. R Medicine The excess accumulation of advanced glycation end products (AGEs) contributes to the chronic complications of type 2 diabetes mellitus (DM) and renal failure. Biopsy specimens (n = 184) of arterial (n = 92) and venous (n = 92) tissues were obtained (radial artery and cephalic vein) from end-stage renal disease (ESRD) patients with or without DM and normal healthy subjects (n = 12) requiring surgery (trauma patients). Immunohistochemical assessment of the blood vessels revealed the presence of pentosidine (AGE marker) in both veins and arteries in 72% of the ESRD patients. The percentage of arteries and veins that showed positive pentosidine staining in ESRD patients with type 2 DM alone was 100% and 92% respectively, in the non-diabetic ESRD patients it was <70% (for arteries and veins), and in the ESRD patients with hypertension as an additional co-morbidity to type 2 DM it was 70% and 82%, respectively. The veins of ESRD patients with DM showed a strong (+++) positive staining and very strong (++++) positive staining was observed in the patients with DM and hypertension. Only mild (+) or moderate (++) pentosidine staining intensity was observed in the arteries of ESRD patients without or with comorbidities, respectively. The accumulation of AGE in the vein rather than the artery may be a better reflection of the extent of complications of ESRD. Arnold Publishers (journals now owned by Sage) 2007-02-15 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2496/1/Vasc_Med-2006-Nazratun-245-50.pdf Nazratun, N. and Mahmood Merican, A. and Kuppusamy, U.R. and Ahmad, T.S. and Tan, S.Y. (2007) Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients. Vascular Medicine, 11 (4). pp. 245-250. ISSN 1358-863X, http://vmj.sagepub.com/content/11/4/245.abstract
spellingShingle R Medicine
Nazratun, N.
Mahmood Merican, A.
Kuppusamy, U.R.
Ahmad, T.S.
Tan, S.Y.
Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients
title Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients
title_full Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients
title_fullStr Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients
title_full_unstemmed Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients
title_short Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients
title_sort diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end stage renal failure patients
topic R Medicine
url http://eprints.um.edu.my/2496/1/Vasc_Med-2006-Nazratun-245-50.pdf
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