Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients
The excess accumulation of advanced glycation end products (AGEs) contributes to the chronic complications of type 2 diabetes mellitus (DM) and renal failure. Biopsy specimens (n = 184) of arterial (n = 92) and venous (n = 92) tissues were obtained (radial artery and cephalic vein) from end-stage re...
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Format: | Article |
Language: | English |
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Arnold Publishers (journals now owned by Sage)
2007
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Online Access: | http://eprints.um.edu.my/2496/1/Vasc_Med-2006-Nazratun-245-50.pdf |
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author | Nazratun, N. Mahmood Merican, A. Kuppusamy, U.R. Ahmad, T.S. Tan, S.Y. |
author_facet | Nazratun, N. Mahmood Merican, A. Kuppusamy, U.R. Ahmad, T.S. Tan, S.Y. |
author_sort | Nazratun, N. |
collection | UM |
description | The excess accumulation of advanced glycation end products (AGEs) contributes to the chronic complications of type 2 diabetes mellitus (DM) and renal failure. Biopsy specimens (n = 184) of arterial (n = 92) and venous (n = 92) tissues were obtained (radial artery and cephalic vein) from end-stage renal disease (ESRD) patients with or without DM and normal healthy subjects (n = 12) requiring surgery (trauma patients). Immunohistochemical assessment of the blood vessels revealed the presence of pentosidine (AGE marker) in both veins and arteries in 72% of the ESRD patients. The percentage of arteries and veins that showed positive pentosidine staining in ESRD patients with type 2 DM alone was 100% and 92% respectively, in the non-diabetic ESRD patients it was <70% (for arteries and veins), and in the ESRD patients with hypertension as an additional co-morbidity to type 2 DM it was 70% and 82%, respectively. The veins of ESRD patients with DM showed a strong (+++) positive staining and very strong (++++) positive staining was observed in the patients with DM and hypertension. Only mild (+) or moderate (++) pentosidine staining intensity was observed in the arteries of ESRD patients without or with comorbidities, respectively. The accumulation of AGE in the vein rather than the artery may be a better reflection of the extent of complications of ESRD. |
first_indexed | 2024-03-06T05:08:12Z |
format | Article |
id | um.eprints-2496 |
institution | Universiti Malaya |
language | English |
last_indexed | 2024-03-06T05:08:12Z |
publishDate | 2007 |
publisher | Arnold Publishers (journals now owned by Sage) |
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spelling | um.eprints-24962014-10-27T06:57:40Z http://eprints.um.edu.my/2496/ Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients Nazratun, N. Mahmood Merican, A. Kuppusamy, U.R. Ahmad, T.S. Tan, S.Y. R Medicine The excess accumulation of advanced glycation end products (AGEs) contributes to the chronic complications of type 2 diabetes mellitus (DM) and renal failure. Biopsy specimens (n = 184) of arterial (n = 92) and venous (n = 92) tissues were obtained (radial artery and cephalic vein) from end-stage renal disease (ESRD) patients with or without DM and normal healthy subjects (n = 12) requiring surgery (trauma patients). Immunohistochemical assessment of the blood vessels revealed the presence of pentosidine (AGE marker) in both veins and arteries in 72% of the ESRD patients. The percentage of arteries and veins that showed positive pentosidine staining in ESRD patients with type 2 DM alone was 100% and 92% respectively, in the non-diabetic ESRD patients it was <70% (for arteries and veins), and in the ESRD patients with hypertension as an additional co-morbidity to type 2 DM it was 70% and 82%, respectively. The veins of ESRD patients with DM showed a strong (+++) positive staining and very strong (++++) positive staining was observed in the patients with DM and hypertension. Only mild (+) or moderate (++) pentosidine staining intensity was observed in the arteries of ESRD patients without or with comorbidities, respectively. The accumulation of AGE in the vein rather than the artery may be a better reflection of the extent of complications of ESRD. Arnold Publishers (journals now owned by Sage) 2007-02-15 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2496/1/Vasc_Med-2006-Nazratun-245-50.pdf Nazratun, N. and Mahmood Merican, A. and Kuppusamy, U.R. and Ahmad, T.S. and Tan, S.Y. (2007) Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients. Vascular Medicine, 11 (4). pp. 245-250. ISSN 1358-863X, http://vmj.sagepub.com/content/11/4/245.abstract |
spellingShingle | R Medicine Nazratun, N. Mahmood Merican, A. Kuppusamy, U.R. Ahmad, T.S. Tan, S.Y. Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients |
title | Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients |
title_full | Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients |
title_fullStr | Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients |
title_full_unstemmed | Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients |
title_short | Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients |
title_sort | diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end stage renal failure patients |
topic | R Medicine |
url | http://eprints.um.edu.my/2496/1/Vasc_Med-2006-Nazratun-245-50.pdf |
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