Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic?
Chemotherapy can cause immunosuppression, which may trigger latent intestinal parasitic infections in stools to emerge. This study investigated whether intestinal parasites can emerge as opportunistic infections in breast and colorectal cancer patients (n=46 and n=15, respectively) undergoing chemot...
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| Format: | Article |
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Oxford University Press
2012
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| author | Chandramathi, S. Suresh, K. Anita, Z.B. Kuppusamy, Umah Rani |
| author_facet | Chandramathi, S. Suresh, K. Anita, Z.B. Kuppusamy, Umah Rani |
| author_sort | Chandramathi, S. |
| collection | UM |
| description | Chemotherapy can cause immunosuppression, which may trigger latent intestinal parasitic infections in stools to emerge. This study investigated whether intestinal parasites can emerge as opportunistic infections in breast and colorectal cancer patients (n=46 and n=15, respectively) undergoing chemotherapy treatment. Breast cancer patients were receiving a 5-fluorouracil/epirubicin/cyclophosphamide (FEC) regimen (6 chemotherapy cycles), and colorectal cancer patients were receiving either an oxaliplatin/5-fluorouracil/folinic acid (FOLFOX) regimen (12 cycles) or a 5-fluorouracil/folinic acid (Mayo) regimen (6 cycles). Patients had Blastocystis hominis and microsporidia infections that were only present during the intermediate chemotherapy cycles. Thus, cancer patients undergoing chemotherapy should be screened repeatedly for intestinal parasites, namely B. hominis and microsporidia, as they may reduce the efficacy of chemotherapy treatments. |
| first_indexed | 2024-03-06T05:08:41Z |
| format | Article |
| id | um.eprints-2776 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:08:41Z |
| publishDate | 2012 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | um.eprints-27762019-03-18T08:21:23Z http://eprints.um.edu.my/2776/ Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? Chandramathi, S. Suresh, K. Anita, Z.B. Kuppusamy, Umah Rani R Medicine Chemotherapy can cause immunosuppression, which may trigger latent intestinal parasitic infections in stools to emerge. This study investigated whether intestinal parasites can emerge as opportunistic infections in breast and colorectal cancer patients (n=46 and n=15, respectively) undergoing chemotherapy treatment. Breast cancer patients were receiving a 5-fluorouracil/epirubicin/cyclophosphamide (FEC) regimen (6 chemotherapy cycles), and colorectal cancer patients were receiving either an oxaliplatin/5-fluorouracil/folinic acid (FOLFOX) regimen (12 cycles) or a 5-fluorouracil/folinic acid (Mayo) regimen (6 cycles). Patients had Blastocystis hominis and microsporidia infections that were only present during the intermediate chemotherapy cycles. Thus, cancer patients undergoing chemotherapy should be screened repeatedly for intestinal parasites, namely B. hominis and microsporidia, as they may reduce the efficacy of chemotherapy treatments. Oxford University Press 2012-02 Article PeerReviewed Chandramathi, S. and Suresh, K. and Anita, Z.B. and Kuppusamy, Umah Rani (2012) Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? Transactions of the Royal Society of Tropical Medicine and Hygiene, 106 (4). pp. 267-269. ISSN 0035-9203, DOI 22340948. https://doi.org/10.1016/j.trstmh.2011.12.008 22340948 |
| spellingShingle | R Medicine Chandramathi, S. Suresh, K. Anita, Z.B. Kuppusamy, Umah Rani Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? |
| title | Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? |
| title_full | Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? |
| title_fullStr | Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? |
| title_full_unstemmed | Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? |
| title_short | Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? |
| title_sort | infections of blastocystis hominis and microsporidia in cancer patients are they opportunistic |
| topic | R Medicine |
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