Naucline, a new indole alkaloid from the bark of nauclea officinalis
A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2...
| المؤلفون الرئيسيون: | , , , , , , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
2012
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://eprints.um.edu.my/3028/1/Naucline_a_New_Indole_Alkaloid_from_the_Bark_of_Nauclea_officinalis.pdf |
| _version_ | 1825718747302723584 |
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| author | Liew, Sook Yee Mukhtar, M.R. Hadi, A.H.A. Awang, Khalijah Mustafa, Mohd Rais Zaima, K. Morita, H. Litaudon, M. |
| author_facet | Liew, Sook Yee Mukhtar, M.R. Hadi, A.H.A. Awang, Khalijah Mustafa, Mohd Rais Zaima, K. Morita, H. Litaudon, M. |
| author_sort | Liew, Sook Yee |
| collection | UM |
| description | A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete 13C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90 relaxation at 1 � 10�5 M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90 relaxation at 1 � 10�5 M) on an isolated rat aorta. |
| first_indexed | 2024-03-06T05:09:05Z |
| format | Article |
| id | um.eprints-3028 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:09:05Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | um.eprints-30282019-03-01T09:17:56Z http://eprints.um.edu.my/3028/ Naucline, a new indole alkaloid from the bark of nauclea officinalis Liew, Sook Yee Mukhtar, M.R. Hadi, A.H.A. Awang, Khalijah Mustafa, Mohd Rais Zaima, K. Morita, H. Litaudon, M. R Medicine A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete 13C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90 relaxation at 1 � 10�5 M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90 relaxation at 1 � 10�5 M) on an isolated rat aorta. 2012-04-02 Article NonPeerReviewed application/pdf en http://eprints.um.edu.my/3028/1/Naucline_a_New_Indole_Alkaloid_from_the_Bark_of_Nauclea_officinalis.pdf Liew, Sook Yee and Mukhtar, M.R. and Hadi, A.H.A. and Awang, Khalijah and Mustafa, Mohd Rais and Zaima, K. and Morita, H. and Litaudon, M. (2012) Naucline, a new indole alkaloid from the bark of nauclea officinalis. Molecules, 17 (4). pp. 4028-4036. ISSN 1420-3049, DOI https://doi.org/10.3390/molecules17044028 <https://doi.org/10.3390/molecules17044028>. http://www.mdpi.com/1420-3049/17/4/4028/ 10.3390/molecules17044028 |
| spellingShingle | R Medicine Liew, Sook Yee Mukhtar, M.R. Hadi, A.H.A. Awang, Khalijah Mustafa, Mohd Rais Zaima, K. Morita, H. Litaudon, M. Naucline, a new indole alkaloid from the bark of nauclea officinalis |
| title | Naucline, a new indole alkaloid from the bark of nauclea officinalis |
| title_full | Naucline, a new indole alkaloid from the bark of nauclea officinalis |
| title_fullStr | Naucline, a new indole alkaloid from the bark of nauclea officinalis |
| title_full_unstemmed | Naucline, a new indole alkaloid from the bark of nauclea officinalis |
| title_short | Naucline, a new indole alkaloid from the bark of nauclea officinalis |
| title_sort | naucline a new indole alkaloid from the bark of nauclea officinalis |
| topic | R Medicine |
| url | http://eprints.um.edu.my/3028/1/Naucline_a_New_Indole_Alkaloid_from_the_Bark_of_Nauclea_officinalis.pdf |
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