Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women.
Preeclampsia (PE) is a major contributor to maternal and fetal mortality. The cause of preeclampsia remains unclear, but oxidative stress on the endothelium leading to endothelial dysfunction is said to be the root cause of the disease. The aim of this study was to measure and determine the plasma l...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
2010
|
| Subjects: |
| _version_ | 1825718432206684160 |
|---|---|
| author | Yelumalai, Suseela Muniandy, Sekaran Zawiah Omar, Siti Qvist, Rajes |
| author_facet | Yelumalai, Suseela Muniandy, Sekaran Zawiah Omar, Siti Qvist, Rajes |
| author_sort | Yelumalai, Suseela |
| collection | UM |
| description | Preeclampsia (PE) is a major contributor to maternal and fetal mortality. The cause of preeclampsia remains unclear, but oxidative stress on the endothelium leading to endothelial dysfunction is said to be the root cause of the disease. The aim of this study was to measure and determine the plasma levels of key angiogenic factors in pregnancy as an indicator for the early onset of preeclampsia in pregnancy. Plasma levels of circulating a soluble fms like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), both pro-angiogenic factors were analyzed in normal pregnant Malaysian women (control group, n = 34), women with pregnant induced hypertension (PIH, n = 34) and women with preeclampsia (PE, n = 34) all at three gestational ages, 24-28 weeks (early pregnancy: EP), 32-36 weeks (late pregnancy: LP) and 6 weeks after delivery (postpartum: PN). The plasma levels of angiogenic factors were determined by ELISA. sFlt-1 levels were elevated in PIH and PE patients as compared to controls. PIGF and VEGF were significantly decreased in PIH and PE as compared to the controls. These results suggest that elevated concentration of sFlt-1 and suppressed levels of PIGF and VEGF may contribute to the development of hypertension in pregnancy which precedes preeclampsia. |
| first_indexed | 2024-03-06T05:04:31Z |
| format | Article |
| id | um.eprints-305 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:04:31Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | um.eprints-3052011-03-02T05:17:46Z http://eprints.um.edu.my/305/ Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women. Yelumalai, Suseela Muniandy, Sekaran Zawiah Omar, Siti Qvist, Rajes RZ Other systems of medicine Preeclampsia (PE) is a major contributor to maternal and fetal mortality. The cause of preeclampsia remains unclear, but oxidative stress on the endothelium leading to endothelial dysfunction is said to be the root cause of the disease. The aim of this study was to measure and determine the plasma levels of key angiogenic factors in pregnancy as an indicator for the early onset of preeclampsia in pregnancy. Plasma levels of circulating a soluble fms like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), both pro-angiogenic factors were analyzed in normal pregnant Malaysian women (control group, n = 34), women with pregnant induced hypertension (PIH, n = 34) and women with preeclampsia (PE, n = 34) all at three gestational ages, 24-28 weeks (early pregnancy: EP), 32-36 weeks (late pregnancy: LP) and 6 weeks after delivery (postpartum: PN). The plasma levels of angiogenic factors were determined by ELISA. sFlt-1 levels were elevated in PIH and PE patients as compared to controls. PIGF and VEGF were significantly decreased in PIH and PE as compared to the controls. These results suggest that elevated concentration of sFlt-1 and suppressed levels of PIGF and VEGF may contribute to the development of hypertension in pregnancy which precedes preeclampsia. 2010-11 Article NonPeerReviewed Yelumalai, Suseela and Muniandy, Sekaran and Zawiah Omar, Siti and Qvist, Rajes (2010) Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women. Journal of Clinical Biochemistry and Nutrition, 47 (3). pp. 191-7. ISSN 1880-5086, DOI 21103027. http://www.ncbi.nlm.nih.gov/pubmed/21103027 21103027 |
| spellingShingle | RZ Other systems of medicine Yelumalai, Suseela Muniandy, Sekaran Zawiah Omar, Siti Qvist, Rajes Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women. |
| title | Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women. |
| title_full | Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women. |
| title_fullStr | Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women. |
| title_full_unstemmed | Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women. |
| title_short | Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women. |
| title_sort | pregnancy induced hypertension and preeclampsia levels of angiogenic factors in malaysian women |
| topic | RZ Other systems of medicine |
| work_keys_str_mv | AT yelumalaisuseela pregnancyinducedhypertensionandpreeclampsialevelsofangiogenicfactorsinmalaysianwomen AT muniandysekaran pregnancyinducedhypertensionandpreeclampsialevelsofangiogenicfactorsinmalaysianwomen AT zawiahomarsiti pregnancyinducedhypertensionandpreeclampsialevelsofangiogenicfactorsinmalaysianwomen AT qvistrajes pregnancyinducedhypertensionandpreeclampsialevelsofangiogenicfactorsinmalaysianwomen |