Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays
Recent findings have shown that the rs1042714 (Gln27Glu) single-nucleotide polymorphism (SNP) on the β2-adrenoceptor gene may predispose to obesity. The findings from other studies carried on different populations, however, have been inconsistent. The authors investigated the association between th...
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| Format: | Article |
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SAGE Publications
2011
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| author | Apalasamy, Y.D. Ming, M.F. Rampal, S. Bulgiba, Awang Mohamed, Z. |
| author_facet | Apalasamy, Y.D. Ming, M.F. Rampal, S. Bulgiba, Awang Mohamed, Z. |
| author_sort | Apalasamy, Y.D. |
| collection | UM |
| description | Recent findings have shown that the rs1042714 (Gln27Glu) single-nucleotide polymorphism (SNP) on the β2-adrenoceptor gene may predispose to obesity. The findings from other studies carried on different populations, however, have been inconsistent. The authors investigated the association between the rs1042714 SNP with obesity-related parameters. DNA of 672 Malaysian Malays was analyzed using real-time polymerase chain reaction. Univariate and multivariate linear regression analyses revealed significant associations between rs1042714 and diastolic blood pressure in the pooled Malaysian Malay subjects under additive and recessive models. After gender stratification, however, a significant association was found between the rs1042714 and triglyceride and the rs1042714 and log-transformed high-density lipoprotein cholesterol levels in Malaysian Malay men. No significant association was found between the SNP and log-transformed body mass index. This polymorphism may have an important role in the development of obesity-related traits in Malaysian Malays. Gender is an effect modifier for the effect of the rs1042714 polymorphism on obesity-related traits in Malaysian Malays. |
| first_indexed | 2024-03-06T05:09:10Z |
| format | Article |
| id | um.eprints-3066 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:09:10Z |
| publishDate | 2011 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | um.eprints-30662019-08-26T07:40:00Z http://eprints.um.edu.my/3066/ Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays Apalasamy, Y.D. Ming, M.F. Rampal, S. Bulgiba, Awang Mohamed, Z. R Medicine Recent findings have shown that the rs1042714 (Gln27Glu) single-nucleotide polymorphism (SNP) on the β2-adrenoceptor gene may predispose to obesity. The findings from other studies carried on different populations, however, have been inconsistent. The authors investigated the association between the rs1042714 SNP with obesity-related parameters. DNA of 672 Malaysian Malays was analyzed using real-time polymerase chain reaction. Univariate and multivariate linear regression analyses revealed significant associations between rs1042714 and diastolic blood pressure in the pooled Malaysian Malay subjects under additive and recessive models. After gender stratification, however, a significant association was found between the rs1042714 and triglyceride and the rs1042714 and log-transformed high-density lipoprotein cholesterol levels in Malaysian Malay men. No significant association was found between the SNP and log-transformed body mass index. This polymorphism may have an important role in the development of obesity-related traits in Malaysian Malays. Gender is an effect modifier for the effect of the rs1042714 polymorphism on obesity-related traits in Malaysian Malays. SAGE Publications 2011 Article PeerReviewed Apalasamy, Y.D. and Ming, M.F. and Rampal, S. and Bulgiba, Awang and Mohamed, Z. (2011) Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays. Asia Pacific Journal of Public Health. ISSN 1010-5395, DOI https://doi.org/10.1177/1010539511430250 <https://doi.org/10.1177/1010539511430250 >. http://www.ncbi.nlm.nih.gov/pubmed/22199155 10.1177/1010539511430250 |
| spellingShingle | R Medicine Apalasamy, Y.D. Ming, M.F. Rampal, S. Bulgiba, Awang Mohamed, Z. Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays |
| title | Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays |
| title_full | Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays |
| title_fullStr | Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays |
| title_full_unstemmed | Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays |
| title_short | Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays |
| title_sort | gender dependent association of a a�a²2 adrenergic gene variant with obesity parameters in malaysian malays |
| topic | R Medicine |
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