Vasodilator effect of phlomis bracteosa constituents is mediated through dual Endothelium-Dependent and Endothelium-Independent pathways
This study describes the vasorelaxant potential of some pure compounds isolated from Phlomis bracteosa L.: marrubiin, phlomeoic acid, and two new constituents labeled as RA and RB. In rat thoracic aortic rings denuded of endothelium, marrubiin, phlomeoic acid, RA, and RB caused relaxation of high K+...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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2012
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| Online Access: | http://eprints.um.edu.my/3294/1/Vasodilator_Effect_of_Phlomis_bracteosa_Constituents_Is.pdf |
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| author | Khan, A. Ullah, R. Mustafa, Mohd Rais Hussain, J. Murugan, D.D. Hadi, A.H.B.A. |
| author_facet | Khan, A. Ullah, R. Mustafa, Mohd Rais Hussain, J. Murugan, D.D. Hadi, A.H.B.A. |
| author_sort | Khan, A. |
| collection | UM |
| description | This study describes the vasorelaxant potential of some pure compounds isolated from Phlomis bracteosa L.: marrubiin, phlomeoic acid, and two new constituents labeled as RA and RB. In rat thoracic aortic rings denuded of endothelium, marrubiin, phlomeoic acid, RA, and RB caused relaxation of high K+ (80 mM) and phenylephrine (1 ìM)-induced contractions at the concentration range of 1.0�1000 ìg/mL. Marrubiin, phlomeoic acid, RA, and RB concentration dependently (3.0�10 ìg/mL) shifted the Ca++ curves to the right obtained in Ca++-free medium. The vasodilator effect of marrubiin, phlomeoic acid, RA, and RB was partially blocked by Nù-nitro-L-arginine methyl ester in endotheliumintact aorta preparations. These results reveal that P. bracteosa constituents: marrubiin, phlomeoic acid, RA, and RB exhibit vasodilator action occurred via a combination of endothelium-independent Ca++ antagonism and endotheliumdependent Nù-nitro-L-arginine methyl ester-sensitive nitric oxide-modulating mechanism. |
| first_indexed | 2024-03-06T05:09:36Z |
| format | Article |
| id | um.eprints-3294 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:09:36Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | um.eprints-32942019-12-18T06:40:08Z http://eprints.um.edu.my/3294/ Vasodilator effect of phlomis bracteosa constituents is mediated through dual Endothelium-Dependent and Endothelium-Independent pathways Khan, A. Ullah, R. Mustafa, Mohd Rais Hussain, J. Murugan, D.D. Hadi, A.H.B.A. R Medicine This study describes the vasorelaxant potential of some pure compounds isolated from Phlomis bracteosa L.: marrubiin, phlomeoic acid, and two new constituents labeled as RA and RB. In rat thoracic aortic rings denuded of endothelium, marrubiin, phlomeoic acid, RA, and RB caused relaxation of high K+ (80 mM) and phenylephrine (1 ìM)-induced contractions at the concentration range of 1.0�1000 ìg/mL. Marrubiin, phlomeoic acid, RA, and RB concentration dependently (3.0�10 ìg/mL) shifted the Ca++ curves to the right obtained in Ca++-free medium. The vasodilator effect of marrubiin, phlomeoic acid, RA, and RB was partially blocked by Nù-nitro-L-arginine methyl ester in endotheliumintact aorta preparations. These results reveal that P. bracteosa constituents: marrubiin, phlomeoic acid, RA, and RB exhibit vasodilator action occurred via a combination of endothelium-independent Ca++ antagonism and endotheliumdependent Nù-nitro-L-arginine methyl ester-sensitive nitric oxide-modulating mechanism. 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3294/1/Vasodilator_Effect_of_Phlomis_bracteosa_Constituents_Is.pdf Khan, A. and Ullah, R. and Mustafa, Mohd Rais and Hussain, J. and Murugan, D.D. and Hadi, A.H.B.A. (2012) Vasodilator effect of phlomis bracteosa constituents is mediated through dual Endothelium-Dependent and Endothelium-Independent pathways. Clinical and Experimental Hypertension, 34 (2). pp. 132-139. ISSN 1064-1963, DOI https://doi.org/10.3109/10641963.2011.601383 <https://doi.org/10.3109/10641963.2011.601383>. http://informahealthcare.com/doi/abs/10.3109/10641963.2011.601383 10.3109/10641963.2011.601383 |
| spellingShingle | R Medicine Khan, A. Ullah, R. Mustafa, Mohd Rais Hussain, J. Murugan, D.D. Hadi, A.H.B.A. Vasodilator effect of phlomis bracteosa constituents is mediated through dual Endothelium-Dependent and Endothelium-Independent pathways |
| title | Vasodilator effect of phlomis bracteosa constituents is mediated through dual Endothelium-Dependent and Endothelium-Independent pathways |
| title_full | Vasodilator effect of phlomis bracteosa constituents is mediated through dual Endothelium-Dependent and Endothelium-Independent pathways |
| title_fullStr | Vasodilator effect of phlomis bracteosa constituents is mediated through dual Endothelium-Dependent and Endothelium-Independent pathways |
| title_full_unstemmed | Vasodilator effect of phlomis bracteosa constituents is mediated through dual Endothelium-Dependent and Endothelium-Independent pathways |
| title_short | Vasodilator effect of phlomis bracteosa constituents is mediated through dual Endothelium-Dependent and Endothelium-Independent pathways |
| title_sort | vasodilator effect of phlomis bracteosa constituents is mediated through dual endothelium dependent and endothelium independent pathways |
| topic | R Medicine |
| url | http://eprints.um.edu.my/3294/1/Vasodilator_Effect_of_Phlomis_bracteosa_Constituents_Is.pdf |
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