Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients
Systemic lupus erythematosus (SLE) is an autoimmune disease that causes systemic damage, involving auto-reactive antibodies and over-deposition of immune complexes. Susceptibility to SLE is believed to be multifactorial, and genetics is one of the proven etiological factors; it can affect SLE develo...
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| Format: | Article |
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2012
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| _version_ | 1796944979647528960 |
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| author | Lian, L.H. Lau, T.P. Ching, A.S. Chua, K.H. |
| author_facet | Lian, L.H. Lau, T.P. Ching, A.S. Chua, K.H. |
| author_sort | Lian, L.H. |
| collection | UM |
| description | Systemic lupus erythematosus (SLE) is an autoimmune disease that causes systemic damage, involving auto-reactive antibodies and over-deposition of immune complexes. Susceptibility to SLE is believed to be multifactorial, and genetics is one of the proven etiological factors; it can affect SLE development, severity and prognosis. We investigated a possible association between the angiotensin-converting enzyme gene and susceptibility to SLE in the Malaysian population. PCR was employed for the determination of I/D dimorphism of this gene. The I allele was more frequent than the D allele in both the SLE patients (N = 170) and healthy controls (N = 190). However, there was no significant difference in the distribution of these two alleles between both groups studied (χ(2) = 0.284, P > 0.05). Interestingly, the DD homozygous genotype scored notably higher in the healthy control group (χ(2) = 7.568, P < 0.05), while the ID heterozygote was observed to be significantly associated with SLE (χ(2) = 11.143, P < 0.05). In conclusion, with respect to the Malaysian population, the DD genotype might play a protective role in the development of SLE while in contrast, those who carry the ID genotype might be at potential risk for onset of this disease. |
| first_indexed | 2024-03-06T05:09:49Z |
| format | Article |
| id | um.eprints-3394 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:09:49Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | um.eprints-33942014-12-16T04:28:15Z http://eprints.um.edu.my/3394/ Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients Lian, L.H. Lau, T.P. Ching, A.S. Chua, K.H. R Medicine Systemic lupus erythematosus (SLE) is an autoimmune disease that causes systemic damage, involving auto-reactive antibodies and over-deposition of immune complexes. Susceptibility to SLE is believed to be multifactorial, and genetics is one of the proven etiological factors; it can affect SLE development, severity and prognosis. We investigated a possible association between the angiotensin-converting enzyme gene and susceptibility to SLE in the Malaysian population. PCR was employed for the determination of I/D dimorphism of this gene. The I allele was more frequent than the D allele in both the SLE patients (N = 170) and healthy controls (N = 190). However, there was no significant difference in the distribution of these two alleles between both groups studied (χ(2) = 0.284, P > 0.05). Interestingly, the DD homozygous genotype scored notably higher in the healthy control group (χ(2) = 7.568, P < 0.05), while the ID heterozygote was observed to be significantly associated with SLE (χ(2) = 11.143, P < 0.05). In conclusion, with respect to the Malaysian population, the DD genotype might play a protective role in the development of SLE while in contrast, those who carry the ID genotype might be at potential risk for onset of this disease. 2012-04 Article PeerReviewed Lian, L.H. and Lau, T.P. and Ching, A.S. and Chua, K.H. (2012) Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients. Genetics and Molecular Research , 11 (2). ISSN 1676-5680, DOI PMID: 22576914. http://www.ncbi.nlm.nih.gov/pubmed/22576914 PMID: 22576914 |
| spellingShingle | R Medicine Lian, L.H. Lau, T.P. Ching, A.S. Chua, K.H. Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients |
| title | Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients |
| title_full | Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients |
| title_fullStr | Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients |
| title_full_unstemmed | Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients |
| title_short | Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients |
| title_sort | angiotensin converting enzyme gene i d dimorphism does not play a major role in the susceptibility of malaysian systemic lupus erythematosus patients |
| topic | R Medicine |
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