The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida
Introduction: C. tropicalis and C. krusei have emerged as virulent species causing oral infections. Both have developed resistance to commonly prescribed azole antifungal agents. Objective: The study aimed to determine the effect of mouth rinses containing chlorhexidine digluconate (CHX), cetylpyrid...
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| Format: | Article |
| Language: | English English |
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2012
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| Online Access: | http://eprints.um.edu.my/3398/1/The_antifungal_properties_of_chlorhexidine_digluconate_and_cetylpyrinidinium_chloride_on_oral_Candida.pdf http://eprints.um.edu.my/3398/2/1-s2.0-S0300571212000863-main.pdf |
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| author | Razak, Fathilah Abdul Himratul-Aznita, Wan Harun Fatheen, A.R.N. Suriani, K.R. |
| author_facet | Razak, Fathilah Abdul Himratul-Aznita, Wan Harun Fatheen, A.R.N. Suriani, K.R. |
| author_sort | Razak, Fathilah Abdul |
| collection | UM |
| description | Introduction: C. tropicalis and C. krusei have emerged as virulent species causing oral infections. Both have developed resistance to commonly prescribed azole antifungal agents. Objective: The study aimed to determine the effect of mouth rinses containing chlorhexidine digluconate (CHX), cetylpyridinium chloride (CPC) and their combination (CHX-CPC) on the growth of these strains. Methods: The minimal inhibition concentrations (MIC) of the mouth rinses were determined. The growth curves of the strains produced under the mouth rinse-treated and untreated conditions, as well as alterations to the morphology of the growth colonies and cells following the treatments were compared and analysed. Results: The MICs of CPC compared to CHX mouth rinses were found to be lower for both Candida sp. In the mixed formulation, CPC doubled the inhibitory effect of CHX towards both Candida sp., while CHX quadrupled the activity of CPC towards C. tropicalis. The growth colonies also appeared coarse, wrinkled and dried. Conclusion: The profound effects shown may suggest the fungicidal activities of the mouth rinses incorporated with CHX, CPC or their combination on both C. tropicalis and C. krusei. Gargling using mouth rinses with such fungicidal activity would enhance a rapid reduction in the candidal population of patients with fungal infection. |
| first_indexed | 2024-03-06T05:09:49Z |
| format | Article |
| id | um.eprints-3398 |
| institution | Universiti Malaya |
| language | English English |
| last_indexed | 2024-03-06T05:09:49Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | um.eprints-33982019-12-23T07:39:50Z http://eprints.um.edu.my/3398/ The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida Razak, Fathilah Abdul Himratul-Aznita, Wan Harun Fatheen, A.R.N. Suriani, K.R. RK Dentistry Introduction: C. tropicalis and C. krusei have emerged as virulent species causing oral infections. Both have developed resistance to commonly prescribed azole antifungal agents. Objective: The study aimed to determine the effect of mouth rinses containing chlorhexidine digluconate (CHX), cetylpyridinium chloride (CPC) and their combination (CHX-CPC) on the growth of these strains. Methods: The minimal inhibition concentrations (MIC) of the mouth rinses were determined. The growth curves of the strains produced under the mouth rinse-treated and untreated conditions, as well as alterations to the morphology of the growth colonies and cells following the treatments were compared and analysed. Results: The MICs of CPC compared to CHX mouth rinses were found to be lower for both Candida sp. In the mixed formulation, CPC doubled the inhibitory effect of CHX towards both Candida sp., while CHX quadrupled the activity of CPC towards C. tropicalis. The growth colonies also appeared coarse, wrinkled and dried. Conclusion: The profound effects shown may suggest the fungicidal activities of the mouth rinses incorporated with CHX, CPC or their combination on both C. tropicalis and C. krusei. Gargling using mouth rinses with such fungicidal activity would enhance a rapid reduction in the candidal population of patients with fungal infection. 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3398/1/The_antifungal_properties_of_chlorhexidine_digluconate_and_cetylpyrinidinium_chloride_on_oral_Candida.pdf application/pdf en http://eprints.um.edu.my/3398/2/1-s2.0-S0300571212000863-main.pdf Razak, Fathilah Abdul and Himratul-Aznita, Wan Harun and Fatheen, A.R.N. and Suriani, K.R. (2012) The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida. Journal of Dentistry, 40 (7). pp. 609-615. ISSN 0300-5712, DOI https://doi.org/10.1016/j.jdent.2012.04.003 <https://doi.org/10.1016/j.jdent.2012.04.003>. 10.1016/j.jdent.2012.04.003 |
| spellingShingle | RK Dentistry Razak, Fathilah Abdul Himratul-Aznita, Wan Harun Fatheen, A.R.N. Suriani, K.R. The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida |
| title | The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida |
| title_full | The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida |
| title_fullStr | The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida |
| title_full_unstemmed | The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida |
| title_short | The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida |
| title_sort | antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral candida |
| topic | RK Dentistry |
| url | http://eprints.um.edu.my/3398/1/The_antifungal_properties_of_chlorhexidine_digluconate_and_cetylpyrinidinium_chloride_on_oral_Candida.pdf http://eprints.um.edu.my/3398/2/1-s2.0-S0300571212000863-main.pdf |
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