Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains
We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from...
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| Format: | Article |
| Language: | English |
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2001
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| Online Access: | http://eprints.um.edu.my/3444/1/Neuraminidase_treatment_abrogates_the_binding_abnormality_of_IgA1_from_IgA_nephropathy_patients.pdf |
| _version_ | 1796944987924987904 |
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| author | Hashim, Onn Haji Shuib, A.S. Chua, C.T. |
| author_facet | Hashim, Onn Haji Shuib, A.S. Chua, C.T. |
| author_sort | Hashim, Onn Haji |
| collection | UM |
| description | We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from normal controls. This differential lectin-binding capacity was abrogated when the experiment was performed on neuraminidase-treated sera. Treatment of the serum IgA1 with neuraminidase also abrogated the differential charge distribution between the alpha -heavy chains of IgA nephropathy patients and normal controls. Copyright (C) 2001 S. Karger AG, Basel. |
| first_indexed | 2024-03-06T05:09:56Z |
| format | Article |
| id | um.eprints-3444 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:09:56Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | um.eprints-34442019-10-24T08:20:46Z http://eprints.um.edu.my/3444/ Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains Hashim, Onn Haji Shuib, A.S. Chua, C.T. R Medicine We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from normal controls. This differential lectin-binding capacity was abrogated when the experiment was performed on neuraminidase-treated sera. Treatment of the serum IgA1 with neuraminidase also abrogated the differential charge distribution between the alpha -heavy chains of IgA nephropathy patients and normal controls. Copyright (C) 2001 S. Karger AG, Basel. 2001 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3444/1/Neuraminidase_treatment_abrogates_the_binding_abnormality_of_IgA1_from_IgA_nephropathy_patients.pdf Hashim, Onn Haji and Shuib, A.S. and Chua, C.T. (2001) Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains. Nephron, 89 (4). pp. 422-425. ISSN 0028-2766, DOI https://doi.org/10.1159/000046114 <https://doi.org/10.1159/000046114>. http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstractBuch&ArtikelNr=46114&ProduktNr=227278 10.1159/000046114 |
| spellingShingle | R Medicine Hashim, Onn Haji Shuib, A.S. Chua, C.T. Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains |
| title | Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains |
| title_full | Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains |
| title_fullStr | Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains |
| title_full_unstemmed | Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains |
| title_short | Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains |
| title_sort | neuraminidase treatment abrogates the binding abnormality of iga1 from iga nephropathy patients and the differential charge distribution of its alpha heavy chains |
| topic | R Medicine |
| url | http://eprints.um.edu.my/3444/1/Neuraminidase_treatment_abrogates_the_binding_abnormality_of_IgA1_from_IgA_nephropathy_patients.pdf |
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