Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement
The effect of Artocarpus integer lectin (lectin C) on the functional activity of guinea-pig complement was investigated. Purified and crude extract of lectin C from six cultivars of Artocarpus integer seeds were found to consume complement and thus decreased the complement-induced haemolytic activit...
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| Format: | Article |
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1994
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| author | Hashim, Onn Haji Gendeh, G.S. Cheong, C.N. Jaafar, M.I.N. |
| author_facet | Hashim, Onn Haji Gendeh, G.S. Cheong, C.N. Jaafar, M.I.N. |
| author_sort | Hashim, Onn Haji |
| collection | UM |
| description | The effect of Artocarpus integer lectin (lectin C) on the functional activity of guinea-pig complement was investigated. Purified and crude extract of lectin C from six cultivars of Artocarpus integer seeds were found to consume complement and thus decreased the complement-induced haemolytic activity of sensitized sheep erythrocytes. The change in the complement-mediated haemolytic activity was significantly decreased when incubation of the lectins was performed in the presence of melibiose. The reversal effect of the carbohydrate, which is a potent inhibitor of the lectin's binding to O-linked oligosaccharides of glycoprotein, demonstrate involvement of the lectins interaction with O-glycans of glycoproteins in the consumption of guinea-pig complement. |
| first_indexed | 2024-03-06T05:09:57Z |
| format | Article |
| id | um.eprints-3449 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:09:57Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | um.eprints-34492019-10-24T08:16:01Z http://eprints.um.edu.my/3449/ Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement Hashim, Onn Haji Gendeh, G.S. Cheong, C.N. Jaafar, M.I.N. R Medicine The effect of Artocarpus integer lectin (lectin C) on the functional activity of guinea-pig complement was investigated. Purified and crude extract of lectin C from six cultivars of Artocarpus integer seeds were found to consume complement and thus decreased the complement-induced haemolytic activity of sensitized sheep erythrocytes. The change in the complement-mediated haemolytic activity was significantly decreased when incubation of the lectins was performed in the presence of melibiose. The reversal effect of the carbohydrate, which is a potent inhibitor of the lectin's binding to O-linked oligosaccharides of glycoprotein, demonstrate involvement of the lectins interaction with O-glycans of glycoproteins in the consumption of guinea-pig complement. 1994 Article PeerReviewed Hashim, Onn Haji and Gendeh, G.S. and Cheong, C.N. and Jaafar, M.I.N. (1994) Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement. Immunological Investigations, 23 (2). pp. 153-160. ISSN 0882-0139, DOI https://doi.org/10.3109/08820139409087796 <https://doi.org/10.3109/08820139409087796>. http://informahealthcare.com/doi/abs/10.3109/08820139409087796 10.3109/08820139409087796 |
| spellingShingle | R Medicine Hashim, Onn Haji Gendeh, G.S. Cheong, C.N. Jaafar, M.I.N. Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement |
| title | Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement |
| title_full | Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement |
| title_fullStr | Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement |
| title_full_unstemmed | Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement |
| title_short | Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement |
| title_sort | effect of artocarpus integer lectin on functional activity of guinea pig complement |
| topic | R Medicine |
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