Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes
The role of paraoxonase 1 in cardiovascular disease complications in type 2 diabetes mellitus is not fully understood. We studied paraoxonase activity towards paraoxon in 188 non-diabetic and 140 diabetic subjects using general linear models and univariate analysis. Adjusting for age revealed a redu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Seameo Regional Tropical Medicine & Public Health
2010
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| Online Access: | http://eprints.um.edu.my/3662/1/4879_sept_2010.pdf |
| _version_ | 1825718836380303360 |
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| author | Poh, R. Muniandy, S. |
| author_facet | Poh, R. Muniandy, S. |
| author_sort | Poh, R. |
| collection | UM |
| description | The role of paraoxonase 1 in cardiovascular disease complications in type 2 diabetes mellitus is not fully understood. We studied paraoxonase activity towards paraoxon in 188 non-diabetic and 140 diabetic subjects using general linear models and univariate analysis. Adjusting for age revealed a reduction in activity towards paraoxon was associated with a significant increase in risk (p=0.023) for cardiovascular disease complications in diabetic patients. Multivariate analysis of two plasma measures of paraoxonase activity using paraoxon and diazoxon also showed reduced paraoxonase activity towards paraoxon was associated with a significant increase in risk (p=0.045) for cardiovascular disease complications in diabetic patients. These analyses showed that a reduced paraoxonase activity towards paraoxon was associated with ethnicity. Based on multivariate analysis, subjects of Malay ethnic origin have significantly higher than expected activity (p=0.008, compared to Indians), towards paraoxon than subjects of Chinese origin who in turn had higher than expected paraoxonase activity (p=0.028, compared to Indians) Indian subjects. |
| first_indexed | 2024-03-06T05:10:26Z |
| format | Article |
| id | um.eprints-3662 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:10:26Z |
| publishDate | 2010 |
| publisher | Seameo Regional Tropical Medicine & Public Health |
| record_format | dspace |
| spelling | um.eprints-36622018-10-19T08:28:16Z http://eprints.um.edu.my/3662/ Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes Poh, R. Muniandy, S. R Medicine The role of paraoxonase 1 in cardiovascular disease complications in type 2 diabetes mellitus is not fully understood. We studied paraoxonase activity towards paraoxon in 188 non-diabetic and 140 diabetic subjects using general linear models and univariate analysis. Adjusting for age revealed a reduction in activity towards paraoxon was associated with a significant increase in risk (p=0.023) for cardiovascular disease complications in diabetic patients. Multivariate analysis of two plasma measures of paraoxonase activity using paraoxon and diazoxon also showed reduced paraoxonase activity towards paraoxon was associated with a significant increase in risk (p=0.045) for cardiovascular disease complications in diabetic patients. These analyses showed that a reduced paraoxonase activity towards paraoxon was associated with ethnicity. Based on multivariate analysis, subjects of Malay ethnic origin have significantly higher than expected activity (p=0.008, compared to Indians), towards paraoxon than subjects of Chinese origin who in turn had higher than expected paraoxonase activity (p=0.028, compared to Indians) Indian subjects. Seameo Regional Tropical Medicine & Public Health 2010 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3662/1/4879_sept_2010.pdf Poh, R. and Muniandy, S. (2010) Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes. Southeast Asian Journal of Tropical Medicine and Public Health, 41 (5). pp. 1231-1246. ISSN 0038-3619, http://www.tm.mahidol.ac.th/seameo/2010-41-5/24-4879.pdf |
| spellingShingle | R Medicine Poh, R. Muniandy, S. Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes |
| title | Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes |
| title_full | Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes |
| title_fullStr | Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes |
| title_full_unstemmed | Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes |
| title_short | Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes |
| title_sort | paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes |
| topic | R Medicine |
| url | http://eprints.um.edu.my/3662/1/4879_sept_2010.pdf |
| work_keys_str_mv | AT pohr paraoxonase1activityasapredictorofcardiovasculardiseaseintype2diabetes AT muniandys paraoxonase1activityasapredictorofcardiovasculardiseaseintype2diabetes |