Genetic risk Factors of systemic lupus erythematosus in the Malaysian population: a minireview
SLE is an autoimmune disease that is not uncommon in Malaysia. In contrast to Malays and Indians, the Chinese seem to be most affected. SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies and failure of immune complex clearance. This minirevie...
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| Format: | Article |
| Language: | English |
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2012
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| Online Access: | http://eprints.um.edu.my/3816/1/Genetic_risk_factors_of_systemic_lupus_erythematosus_in_the_Malaysian_population_-_A_mini_review..pdf |
| _version_ | 1796945044595277824 |
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| author | Hwa Chia, C. Maude Elvira, P. Chua, K.H. |
| author_facet | Hwa Chia, C. Maude Elvira, P. Chua, K.H. |
| author_sort | Hwa Chia, C. |
| collection | UM |
| description | SLE is an autoimmune disease that is not uncommon in Malaysia. In contrast to Malays and Indians, the Chinese seem to be most affected. SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies and failure of immune complex clearance. This minireview attempts to summarize the association of several candidate genes with risk for SLE in the Malaysian population and discuss the genetic heterogeneity that exists locally in Asians and in comparison with SLE in Caucasians. Several groups of researchers have been actively investigating genes that are associated with SLE susceptibility in the Malaysian population by screening possible reported candidate genes across the SLE patients and healthy controls. These candidate genes include MHC genes and genes encoding complement components, TNF, FcγR, T-cell receptors, and interleukins. However, most of the polymorphisms investigated in these genes did not show significant associations with susceptibility to SLE in the Malaysian scenario, except for those occurring in MHC genes and genes coding for TNF-α, IL-1β, IL-1RN, and IL-6. |
| first_indexed | 2024-03-06T05:10:46Z |
| format | Article |
| id | um.eprints-3816 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:10:46Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | um.eprints-38162012-11-01T07:43:12Z http://eprints.um.edu.my/3816/ Genetic risk Factors of systemic lupus erythematosus in the Malaysian population: a minireview Hwa Chia, C. Maude Elvira, P. Chua, K.H. R Medicine SLE is an autoimmune disease that is not uncommon in Malaysia. In contrast to Malays and Indians, the Chinese seem to be most affected. SLE is characterized by deficiency of body's immune response that leads to production of autoantibodies and failure of immune complex clearance. This minireview attempts to summarize the association of several candidate genes with risk for SLE in the Malaysian population and discuss the genetic heterogeneity that exists locally in Asians and in comparison with SLE in Caucasians. Several groups of researchers have been actively investigating genes that are associated with SLE susceptibility in the Malaysian population by screening possible reported candidate genes across the SLE patients and healthy controls. These candidate genes include MHC genes and genes encoding complement components, TNF, FcγR, T-cell receptors, and interleukins. However, most of the polymorphisms investigated in these genes did not show significant associations with susceptibility to SLE in the Malaysian scenario, except for those occurring in MHC genes and genes coding for TNF-α, IL-1β, IL-1RN, and IL-6. 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3816/1/Genetic_risk_factors_of_systemic_lupus_erythematosus_in_the_Malaysian_population_-_A_mini_review..pdf Hwa Chia, C. and Maude Elvira, P. and Chua, K.H. (2012) Genetic risk Factors of systemic lupus erythematosus in the Malaysian population: a minireview. Clinical and Developmental Immunology, 2012. ISSN 1740-2522, |
| spellingShingle | R Medicine Hwa Chia, C. Maude Elvira, P. Chua, K.H. Genetic risk Factors of systemic lupus erythematosus in the Malaysian population: a minireview |
| title | Genetic risk Factors of systemic lupus erythematosus in the Malaysian population: a minireview |
| title_full | Genetic risk Factors of systemic lupus erythematosus in the Malaysian population: a minireview |
| title_fullStr | Genetic risk Factors of systemic lupus erythematosus in the Malaysian population: a minireview |
| title_full_unstemmed | Genetic risk Factors of systemic lupus erythematosus in the Malaysian population: a minireview |
| title_short | Genetic risk Factors of systemic lupus erythematosus in the Malaysian population: a minireview |
| title_sort | genetic risk factors of systemic lupus erythematosus in the malaysian population a minireview |
| topic | R Medicine |
| url | http://eprints.um.edu.my/3816/1/Genetic_risk_factors_of_systemic_lupus_erythematosus_in_the_Malaysian_population_-_A_mini_review..pdf |
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