Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population
Regulated on activation, normal T-cell expressed and secreted (RANTES) and stromal cell-derived factor 1 (SDF-1) are members of the CC- and CXC-chemokine families, respectively. Both genes have been postulated to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We analyzed posi...
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| Format: | Article |
| Language: | English |
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2011
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| Online Access: | http://eprints.um.edu.my/3835/1/Lack_of_association_between_RANTES-28%2C_SDF-1_gene_polymorphisms_and_systemic_lupus_erythematosus_in_the_Malaysian_population..pdf |
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| author | Lian, L.H. Kee, B.P. Ng, H.L. Chua, K.H. |
| author_facet | Lian, L.H. Kee, B.P. Ng, H.L. Chua, K.H. |
| author_sort | Lian, L.H. |
| collection | UM |
| description | Regulated on activation, normal T-cell expressed and secreted (RANTES) and stromal cell-derived factor 1 (SDF-1) are members of the CC- and CXC-chemokine families, respectively. Both genes have been postulated to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We analyzed position 28 of the RANTES gene promoter region, as well as the SNP observed in the 3' UTR of the SDF-1 gene at position 801, in 130 patients presenting SLE at the Malaya University Medical Centre. Screening of 130 healthy volunteer controls using RFLP was also performed. RANTES-28 polymorphism analysis showed no significant (P = 0.3520) relationship, even though homozygous C/C was more frequent in SLE patients (OR = 1.4183) and heterozygous C/G was more frequent in healthy controls (OR = 0.7051). There were no significant (P = 0.2650) associations between A/A (OR = 0.783), G/G (OR = 1.5914) and G/A (OR = 0.8289) genotypes in the SDF-1 gene polymorphism with SLE. We conclude that there is no significant association of RANTES-28 and SDF-1 gene polymorphisms and occurrence of SLE in Malaysia. |
| first_indexed | 2024-03-06T05:10:48Z |
| format | Article |
| id | um.eprints-3835 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:10:48Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | um.eprints-38352012-11-08T04:08:55Z http://eprints.um.edu.my/3835/ Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population Lian, L.H. Kee, B.P. Ng, H.L. Chua, K.H. R Medicine Regulated on activation, normal T-cell expressed and secreted (RANTES) and stromal cell-derived factor 1 (SDF-1) are members of the CC- and CXC-chemokine families, respectively. Both genes have been postulated to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We analyzed position 28 of the RANTES gene promoter region, as well as the SNP observed in the 3' UTR of the SDF-1 gene at position 801, in 130 patients presenting SLE at the Malaya University Medical Centre. Screening of 130 healthy volunteer controls using RFLP was also performed. RANTES-28 polymorphism analysis showed no significant (P = 0.3520) relationship, even though homozygous C/C was more frequent in SLE patients (OR = 1.4183) and heterozygous C/G was more frequent in healthy controls (OR = 0.7051). There were no significant (P = 0.2650) associations between A/A (OR = 0.783), G/G (OR = 1.5914) and G/A (OR = 0.8289) genotypes in the SDF-1 gene polymorphism with SLE. We conclude that there is no significant association of RANTES-28 and SDF-1 gene polymorphisms and occurrence of SLE in Malaysia. 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3835/1/Lack_of_association_between_RANTES-28%2C_SDF-1_gene_polymorphisms_and_systemic_lupus_erythematosus_in_the_Malaysian_population..pdf Lian, L.H. and Kee, B.P. and Ng, H.L. and Chua, K.H. (2011) Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population. Genetics and Molecular Research in 2011, 10 (4). pp. 2841-2850. ISSN 1676-5680, |
| spellingShingle | R Medicine Lian, L.H. Kee, B.P. Ng, H.L. Chua, K.H. Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population |
| title | Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population |
| title_full | Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population |
| title_fullStr | Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population |
| title_full_unstemmed | Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population |
| title_short | Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population |
| title_sort | lack of association between rantes 28 sdf 1 gene polymorphisms and systemic lupus erythematosus in the malaysian population |
| topic | R Medicine |
| url | http://eprints.um.edu.my/3835/1/Lack_of_association_between_RANTES-28%2C_SDF-1_gene_polymorphisms_and_systemic_lupus_erythematosus_in_the_Malaysian_population..pdf |
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