IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS

IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS

Dendritic cells (DC) are the main producers of the cytokine IL-12p70, through which they play a direct role in the development of IFN-gamma-secreting Th1 cells, costimulation of CTL differentiation and NK-cell activation. In contrast, IL-10, which is also produced by DC, negatively regulates IL-12 p...

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Bibliographic Details
Main Authors:	Peng, Judy C., AbuBakar, Sazaly, Richardson, Michelle M., Jonsson, Julie J., Frazer, Ian H., Nielsen, Lars K., Morahan, Grant, Thomas, Ranjeny
Format:	Article
Language:	English
Published:	Australasian Society for Immunology (ASI) 2006
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/3971/1/Peng-2006-IL10_and_IL12B_polym.pdf

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