Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma
Background: The general enhanced expression of alpha(1)-antichymotrypsin (ACT), clusterin (CLU), alpha(1)-antitrypsin (AAT), haptoglobin beta-chain (HAP), and leucine rich glycoprotein (LRG) in the sera of patients with epithelial ovarian carcinoma (EOCa) was recently reported. In the present study,...
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| Format: | Article |
| Language: | English |
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BMC
2009
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| Online Access: | http://eprints.um.edu.my/4034/1/Different_altered_stage_correlative_expression_of_high_abundance_acute-phase_proteins_in_sera_of_patients_with_epithelial_ovarian_carcinoma.pdf |
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| author | Chen, Yeng Lim, Boon Kiong Hashim, Onn Haji |
| author_facet | Chen, Yeng Lim, Boon Kiong Hashim, Onn Haji |
| author_sort | Chen, Yeng |
| collection | UM |
| description | Background: The general enhanced expression of alpha(1)-antichymotrypsin (ACT), clusterin (CLU), alpha(1)-antitrypsin (AAT), haptoglobin beta-chain (HAP), and leucine rich glycoprotein (LRG) in the sera of patients with epithelial ovarian carcinoma (EOCa) was recently reported. In the present study, we compared the expression of the serum acute-phase proteins (APPs) in the patients according to their stages of cancer. Results: Different altered stage correlative expression of the high abundance serum APPs was demonstrated in sera of the patients studied. While the expression of ACT, HAP and AAT appeared to demonstrate positive correlation with the three initial stages of the cancer, inverse correlation was apparently detected in the expression of LRG and CLU. For patients who were diagnosed with stage IV of the cancer, expression of the serum APPs did not conform to the altered progression changes. Conclusion: Our results highlight the potential prognostic significance of selective high abundance serum APPs in patients with EOCa. |
| first_indexed | 2024-03-06T05:11:11Z |
| format | Article |
| id | um.eprints-4034 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:11:11Z |
| publishDate | 2009 |
| publisher | BMC |
| record_format | dspace |
| spelling | um.eprints-40342020-07-13T06:59:17Z http://eprints.um.edu.my/4034/ Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma Chen, Yeng Lim, Boon Kiong Hashim, Onn Haji R Medicine Background: The general enhanced expression of alpha(1)-antichymotrypsin (ACT), clusterin (CLU), alpha(1)-antitrypsin (AAT), haptoglobin beta-chain (HAP), and leucine rich glycoprotein (LRG) in the sera of patients with epithelial ovarian carcinoma (EOCa) was recently reported. In the present study, we compared the expression of the serum acute-phase proteins (APPs) in the patients according to their stages of cancer. Results: Different altered stage correlative expression of the high abundance serum APPs was demonstrated in sera of the patients studied. While the expression of ACT, HAP and AAT appeared to demonstrate positive correlation with the three initial stages of the cancer, inverse correlation was apparently detected in the expression of LRG and CLU. For patients who were diagnosed with stage IV of the cancer, expression of the serum APPs did not conform to the altered progression changes. Conclusion: Our results highlight the potential prognostic significance of selective high abundance serum APPs in patients with EOCa. BMC 2009 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4034/1/Different_altered_stage_correlative_expression_of_high_abundance_acute-phase_proteins_in_sera_of_patients_with_epithelial_ovarian_carcinoma.pdf Chen, Yeng and Lim, Boon Kiong and Hashim, Onn Haji (2009) Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma. Journal of Hematology & Oncology, 2. p. 37. ISSN 1756-8722, DOI https://doi.org/10.1186/1756-8722-2-37 <https://doi.org/10.1186/1756-8722-2-37>. https://doi.org/10.1186/1756-8722-2-37 doi:10.1186/1756-8722-2-37 |
| spellingShingle | R Medicine Chen, Yeng Lim, Boon Kiong Hashim, Onn Haji Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma |
| title | Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma |
| title_full | Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma |
| title_fullStr | Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma |
| title_full_unstemmed | Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma |
| title_short | Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma |
| title_sort | different altered stage correlative expression of high abundance acute phase proteins in sera of patients with epithelial ovarian carcinoma |
| topic | R Medicine |
| url | http://eprints.um.edu.my/4034/1/Different_altered_stage_correlative_expression_of_high_abundance_acute-phase_proteins_in_sera_of_patients_with_epithelial_ovarian_carcinoma.pdf |
| work_keys_str_mv | AT chenyeng differentalteredstagecorrelativeexpressionofhighabundanceacutephaseproteinsinseraofpatientswithepithelialovariancarcinoma AT limboonkiong differentalteredstagecorrelativeexpressionofhighabundanceacutephaseproteinsinseraofpatientswithepithelialovariancarcinoma AT hashimonnhaji differentalteredstagecorrelativeexpressionofhighabundanceacutephaseproteinsinseraofpatientswithepithelialovariancarcinoma |