Antimalarial activity of methanolic leaf extract of piper betle L
The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract of Piper betle leaves (50-400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei (NK65) dur...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2011
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| Online Access: | http://eprints.um.edu.my/4229/1/Al-Adhroey-2011-Antimalarial_Activit.pdf |
| _version_ | 1796945099400151040 |
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| author | Al-Adhroey, A.H. Nor, Z.M. Al-Mekhlafi, H.M. Amran, A.A. Mahmud, R. |
| author_facet | Al-Adhroey, A.H. Nor, Z.M. Al-Mekhlafi, H.M. Amran, A.A. Mahmud, R. |
| author_sort | Al-Adhroey, A.H. |
| collection | UM |
| description | The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract of Piper betle leaves (50-400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei (NK65) during early and established infections. The phytochemical and antioxidant potentials of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. The safety of the extract was also investigated in ICR mice of both sexes by the acute oral toxicity limit test. The leaf extract demonstrated significant (P < 0.05) schizonticidal activity in all three antimalarial evaluation models. Phytochemical screening showed that the leaf extract contains some vital antiplasmodial chemical constituents. The extract also exhibited a potent ability to scavenge the free radicals. The results of acute toxicity showed that the methanol extract of Piper betle leaves is toxicologically safe by oral administration. The results suggest that the Malaysian folklorical medicinal application of the extract of Piper betle leaf has a pharmacological basis. |
| first_indexed | 2024-03-06T05:11:35Z |
| format | Article |
| id | um.eprints-4229 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:11:35Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | um.eprints-42292013-01-08T01:39:08Z http://eprints.um.edu.my/4229/ Antimalarial activity of methanolic leaf extract of piper betle L Al-Adhroey, A.H. Nor, Z.M. Al-Mekhlafi, H.M. Amran, A.A. Mahmud, R. R Medicine The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract of Piper betle leaves (50-400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei (NK65) during early and established infections. The phytochemical and antioxidant potentials of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. The safety of the extract was also investigated in ICR mice of both sexes by the acute oral toxicity limit test. The leaf extract demonstrated significant (P < 0.05) schizonticidal activity in all three antimalarial evaluation models. Phytochemical screening showed that the leaf extract contains some vital antiplasmodial chemical constituents. The extract also exhibited a potent ability to scavenge the free radicals. The results of acute toxicity showed that the methanol extract of Piper betle leaves is toxicologically safe by oral administration. The results suggest that the Malaysian folklorical medicinal application of the extract of Piper betle leaf has a pharmacological basis. 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4229/1/Al-Adhroey-2011-Antimalarial_Activit.pdf Al-Adhroey, A.H. and Nor, Z.M. and Al-Mekhlafi, H.M. and Amran, A.A. and Mahmud, R. (2011) Antimalarial activity of methanolic leaf extract of piper betle L. Molecules, 16 (1). pp. 107-118. ISSN 1420-3049, |
| spellingShingle | R Medicine Al-Adhroey, A.H. Nor, Z.M. Al-Mekhlafi, H.M. Amran, A.A. Mahmud, R. Antimalarial activity of methanolic leaf extract of piper betle L |
| title | Antimalarial activity of methanolic leaf extract of piper betle L |
| title_full | Antimalarial activity of methanolic leaf extract of piper betle L |
| title_fullStr | Antimalarial activity of methanolic leaf extract of piper betle L |
| title_full_unstemmed | Antimalarial activity of methanolic leaf extract of piper betle L |
| title_short | Antimalarial activity of methanolic leaf extract of piper betle L |
| title_sort | antimalarial activity of methanolic leaf extract of piper betle l |
| topic | R Medicine |
| url | http://eprints.um.edu.my/4229/1/Al-Adhroey-2011-Antimalarial_Activit.pdf |
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