Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine
Ethnopharmacological relevance: White flesh extract of Cocos nucifera (coconut) was studied to ascertain the ethnopharmacological standing of its antimalarial usage in Malaysian folk medicine. Materials and methods: The crude methanol extract was investigated for phytochemical constituents and acute...
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| Formato: | Artigo |
| Idioma: | English |
| Publicado: |
2011
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| Acceso en liña: | http://eprints.um.edu.my/4230/1/Al-Adhroey-2011-Evaluation_of_the_us.pdf |
| _version_ | 1825718916335271936 |
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| author | Al-Adhroey, A.H. Nor, Z.M. Al-Mekhlafi, H.M. Amran, A.A. Mahmud, R. |
| author_facet | Al-Adhroey, A.H. Nor, Z.M. Al-Mekhlafi, H.M. Amran, A.A. Mahmud, R. |
| author_sort | Al-Adhroey, A.H. |
| collection | UM |
| description | Ethnopharmacological relevance: White flesh extract of Cocos nucifera (coconut) was studied to ascertain the ethnopharmacological standing of its antimalarial usage in Malaysian folk medicine. Materials and methods: The crude methanol extract was investigated for phytochemical constituents and acute oral toxicity. Antimalarial activity of different extract doses of 50, 100, 200 and 400 mg/kg were investigated in vivo against Plasmodium berghei (NK65) infections in mice during early, established and residual infections. Chloroquine (20 mg/kg) and pyrimethamine (1.2 mg/kg) were used as reference drugs. Results: The results revealed that the extract contained some phytochemical constituents and is toxicologically safe by oral administration. The extract significantly reduced the parasitaemia by the 200 and 400 mg/kg doses in the all three in vivo assessment assays. However, the extract did not significantly increase the survival time of the infected mice. Conclusions: The observed pharmacological activities suggest that the Malaysian folkloric medicinal application of Cocos nucifera has a pharmacological basis. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
| first_indexed | 2024-03-06T05:11:36Z |
| format | Article |
| id | um.eprints-4230 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:11:36Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | um.eprints-42302013-01-08T01:55:17Z http://eprints.um.edu.my/4230/ Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine Al-Adhroey, A.H. Nor, Z.M. Al-Mekhlafi, H.M. Amran, A.A. Mahmud, R. R Medicine Ethnopharmacological relevance: White flesh extract of Cocos nucifera (coconut) was studied to ascertain the ethnopharmacological standing of its antimalarial usage in Malaysian folk medicine. Materials and methods: The crude methanol extract was investigated for phytochemical constituents and acute oral toxicity. Antimalarial activity of different extract doses of 50, 100, 200 and 400 mg/kg were investigated in vivo against Plasmodium berghei (NK65) infections in mice during early, established and residual infections. Chloroquine (20 mg/kg) and pyrimethamine (1.2 mg/kg) were used as reference drugs. Results: The results revealed that the extract contained some phytochemical constituents and is toxicologically safe by oral administration. The extract significantly reduced the parasitaemia by the 200 and 400 mg/kg doses in the all three in vivo assessment assays. However, the extract did not significantly increase the survival time of the infected mice. Conclusions: The observed pharmacological activities suggest that the Malaysian folkloric medicinal application of Cocos nucifera has a pharmacological basis. (C) 2011 Elsevier Ireland Ltd. All rights reserved. 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4230/1/Al-Adhroey-2011-Evaluation_of_the_us.pdf Al-Adhroey, A.H. and Nor, Z.M. and Al-Mekhlafi, H.M. and Amran, A.A. and Mahmud, R. (2011) Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine. Journal of Ethnopharmacology, 134 (3). pp. 988-991. ISSN 0378-8741, |
| spellingShingle | R Medicine Al-Adhroey, A.H. Nor, Z.M. Al-Mekhlafi, H.M. Amran, A.A. Mahmud, R. Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine |
| title | Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine |
| title_full | Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine |
| title_fullStr | Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine |
| title_full_unstemmed | Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine |
| title_short | Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine |
| title_sort | evaluation of the use of cocos nucifera as antimalarial remedy in malaysian folk medicine |
| topic | R Medicine |
| url | http://eprints.um.edu.my/4230/1/Al-Adhroey-2011-Evaluation_of_the_us.pdf |
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