Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine

Ethnopharmacological relevance: White flesh extract of Cocos nucifera (coconut) was studied to ascertain the ethnopharmacological standing of its antimalarial usage in Malaysian folk medicine. Materials and methods: The crude methanol extract was investigated for phytochemical constituents and acute...

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Main Authors: Al-Adhroey, A.H., Nor, Z.M., Al-Mekhlafi, H.M., Amran, A.A., Mahmud, R.
Format: Article
Language:English
Published: 2011
Subjects:
Online Access:http://eprints.um.edu.my/4230/1/Al-Adhroey-2011-Evaluation_of_the_us.pdf
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author Al-Adhroey, A.H.
Nor, Z.M.
Al-Mekhlafi, H.M.
Amran, A.A.
Mahmud, R.
author_facet Al-Adhroey, A.H.
Nor, Z.M.
Al-Mekhlafi, H.M.
Amran, A.A.
Mahmud, R.
author_sort Al-Adhroey, A.H.
collection UM
description Ethnopharmacological relevance: White flesh extract of Cocos nucifera (coconut) was studied to ascertain the ethnopharmacological standing of its antimalarial usage in Malaysian folk medicine. Materials and methods: The crude methanol extract was investigated for phytochemical constituents and acute oral toxicity. Antimalarial activity of different extract doses of 50, 100, 200 and 400 mg/kg were investigated in vivo against Plasmodium berghei (NK65) infections in mice during early, established and residual infections. Chloroquine (20 mg/kg) and pyrimethamine (1.2 mg/kg) were used as reference drugs. Results: The results revealed that the extract contained some phytochemical constituents and is toxicologically safe by oral administration. The extract significantly reduced the parasitaemia by the 200 and 400 mg/kg doses in the all three in vivo assessment assays. However, the extract did not significantly increase the survival time of the infected mice. Conclusions: The observed pharmacological activities suggest that the Malaysian folkloric medicinal application of Cocos nucifera has a pharmacological basis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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spelling um.eprints-42302013-01-08T01:55:17Z http://eprints.um.edu.my/4230/ Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine Al-Adhroey, A.H. Nor, Z.M. Al-Mekhlafi, H.M. Amran, A.A. Mahmud, R. R Medicine Ethnopharmacological relevance: White flesh extract of Cocos nucifera (coconut) was studied to ascertain the ethnopharmacological standing of its antimalarial usage in Malaysian folk medicine. Materials and methods: The crude methanol extract was investigated for phytochemical constituents and acute oral toxicity. Antimalarial activity of different extract doses of 50, 100, 200 and 400 mg/kg were investigated in vivo against Plasmodium berghei (NK65) infections in mice during early, established and residual infections. Chloroquine (20 mg/kg) and pyrimethamine (1.2 mg/kg) were used as reference drugs. Results: The results revealed that the extract contained some phytochemical constituents and is toxicologically safe by oral administration. The extract significantly reduced the parasitaemia by the 200 and 400 mg/kg doses in the all three in vivo assessment assays. However, the extract did not significantly increase the survival time of the infected mice. Conclusions: The observed pharmacological activities suggest that the Malaysian folkloric medicinal application of Cocos nucifera has a pharmacological basis. (C) 2011 Elsevier Ireland Ltd. All rights reserved. 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4230/1/Al-Adhroey-2011-Evaluation_of_the_us.pdf Al-Adhroey, A.H. and Nor, Z.M. and Al-Mekhlafi, H.M. and Amran, A.A. and Mahmud, R. (2011) Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine. Journal of Ethnopharmacology, 134 (3). pp. 988-991. ISSN 0378-8741,
spellingShingle R Medicine
Al-Adhroey, A.H.
Nor, Z.M.
Al-Mekhlafi, H.M.
Amran, A.A.
Mahmud, R.
Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine
title Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine
title_full Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine
title_fullStr Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine
title_full_unstemmed Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine
title_short Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine
title_sort evaluation of the use of cocos nucifera as antimalarial remedy in malaysian folk medicine
topic R Medicine
url http://eprints.um.edu.my/4230/1/Al-Adhroey-2011-Evaluation_of_the_us.pdf
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