High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)
A total of 685 clinical Streptococcus pneumoniae isolates from patients with pneumococcal diseases were collected from 14 centers in 11 Asian countries from January 2000 to June 2001. The in vitro susceptibilities of the isolates to 14 antimicrobial agents were determined by the broth microdilution...
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| Format: | Article |
| Language: | English |
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2004
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| Online Access: | http://eprints.um.edu.my/4587/1/Song-2004-High_prevalence_of_a.pdf |
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| author | Song, J.H. Jung, S.I. Ko, K.S. Kim, N.Y. Son, J.S. Chang, H.H. Ki, H.K. Oh, W.S. Suh, J.Y. Peck, K.R. Lee, N.Y. Yang, Y.H. Lu, Q. Chongthaleong, A. Chiu, C.H. Lalitha, M.K. Perera, J. Yee, T.T. Kumarasinghe, G. Jamal, F. Kamarulzaman, Adeeba Parasakthi, N. Van, P.H. Carlos, C. So, T. Ng, T.K. Shibl, A. |
| author_facet | Song, J.H. Jung, S.I. Ko, K.S. Kim, N.Y. Son, J.S. Chang, H.H. Ki, H.K. Oh, W.S. Suh, J.Y. Peck, K.R. Lee, N.Y. Yang, Y.H. Lu, Q. Chongthaleong, A. Chiu, C.H. Lalitha, M.K. Perera, J. Yee, T.T. Kumarasinghe, G. Jamal, F. Kamarulzaman, Adeeba Parasakthi, N. Van, P.H. Carlos, C. So, T. Ng, T.K. Shibl, A. |
| author_sort | Song, J.H. |
| collection | UM |
| description | A total of 685 clinical Streptococcus pneumoniae isolates from patients with pneumococcal diseases were collected from 14 centers in 11 Asian countries from January 2000 to June 2001. The in vitro susceptibilities of the isolates to 14 antimicrobial agents were determined by the broth microdilution test. Among the isolates tested, 483 (52.4) were not susceptible to penicillin, 23 were intermediate, and 29.4 were penicillin resistant (MICs greater than or equal to 2 mg/liter). Isolates from Vietnam showed the highest prevalence of penicillin resistance (71.4), followed by those from Korea (54.8), Hong Kong (43.2), and Taiwan (38.6). The penicillin MICs at which 90 of isolates are inhibited (MIC(90)s) were 4 mg/liter among isolates from Vietnam, Hong Kong, Korea, and Taiwan. The prevalence of erythromycin resistance was also very high in Vietnam (92.1), Taiwan (86), Korea (80.6), Hong Kong (76.8), and China (73.9). The MIC(90)s of erythromycin were >32 mg/liter among isolates from Korea, Vietnam, China, Taiwan, Singapore, Malaysia, and Hong Kong. Isolates from Hong Kong showed the highest rate of ciprofloxacin resistance (11.8), followed by isolates from Sri Lanka (9.5), the Philippines (9.1), and Korea (6.5). Multilocus sequence typing showed that the spread of the Taiwan(19F) clone and the Spain(23F) clone could be one of the major reasons for the rapid increases in antimicrobial resistance among S. pneumoniae isolates in Asia. Data from the multinational surveillance study clearly documented distinctive increases in the prevalence rates and the levels of antimicrobial resistance among S. pneumoniae isolates in many Asian countries, which are among the highest in the world published to date. |
| first_indexed | 2024-03-06T05:12:20Z |
| format | Article |
| id | um.eprints-4587 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:12:20Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | um.eprints-45872019-12-03T10:52:30Z http://eprints.um.edu.my/4587/ High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study) Song, J.H. Jung, S.I. Ko, K.S. Kim, N.Y. Son, J.S. Chang, H.H. Ki, H.K. Oh, W.S. Suh, J.Y. Peck, K.R. Lee, N.Y. Yang, Y.H. Lu, Q. Chongthaleong, A. Chiu, C.H. Lalitha, M.K. Perera, J. Yee, T.T. Kumarasinghe, G. Jamal, F. Kamarulzaman, Adeeba Parasakthi, N. Van, P.H. Carlos, C. So, T. Ng, T.K. Shibl, A. R Medicine A total of 685 clinical Streptococcus pneumoniae isolates from patients with pneumococcal diseases were collected from 14 centers in 11 Asian countries from January 2000 to June 2001. The in vitro susceptibilities of the isolates to 14 antimicrobial agents were determined by the broth microdilution test. Among the isolates tested, 483 (52.4) were not susceptible to penicillin, 23 were intermediate, and 29.4 were penicillin resistant (MICs greater than or equal to 2 mg/liter). Isolates from Vietnam showed the highest prevalence of penicillin resistance (71.4), followed by those from Korea (54.8), Hong Kong (43.2), and Taiwan (38.6). The penicillin MICs at which 90 of isolates are inhibited (MIC(90)s) were 4 mg/liter among isolates from Vietnam, Hong Kong, Korea, and Taiwan. The prevalence of erythromycin resistance was also very high in Vietnam (92.1), Taiwan (86), Korea (80.6), Hong Kong (76.8), and China (73.9). The MIC(90)s of erythromycin were >32 mg/liter among isolates from Korea, Vietnam, China, Taiwan, Singapore, Malaysia, and Hong Kong. Isolates from Hong Kong showed the highest rate of ciprofloxacin resistance (11.8), followed by isolates from Sri Lanka (9.5), the Philippines (9.1), and Korea (6.5). Multilocus sequence typing showed that the spread of the Taiwan(19F) clone and the Spain(23F) clone could be one of the major reasons for the rapid increases in antimicrobial resistance among S. pneumoniae isolates in Asia. Data from the multinational surveillance study clearly documented distinctive increases in the prevalence rates and the levels of antimicrobial resistance among S. pneumoniae isolates in many Asian countries, which are among the highest in the world published to date. 2004 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4587/1/Song-2004-High_prevalence_of_a.pdf Song, J.H. and Jung, S.I. and Ko, K.S. and Kim, N.Y. and Son, J.S. and Chang, H.H. and Ki, H.K. and Oh, W.S. and Suh, J.Y. and Peck, K.R. and Lee, N.Y. and Yang, Y.H. and Lu, Q. and Chongthaleong, A. and Chiu, C.H. and Lalitha, M.K. and Perera, J. and Yee, T.T. and Kumarasinghe, G. and Jamal, F. and Kamarulzaman, Adeeba and Parasakthi, N. and Van, P.H. and Carlos, C. and So, T. and Ng, T.K. and Shibl, A. (2004) High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study). Antimicrobial Agents and Chemotherapy, 48 (6). pp. 2101-2107. ISSN 0066-4804, |
| spellingShingle | R Medicine Song, J.H. Jung, S.I. Ko, K.S. Kim, N.Y. Son, J.S. Chang, H.H. Ki, H.K. Oh, W.S. Suh, J.Y. Peck, K.R. Lee, N.Y. Yang, Y.H. Lu, Q. Chongthaleong, A. Chiu, C.H. Lalitha, M.K. Perera, J. Yee, T.T. Kumarasinghe, G. Jamal, F. Kamarulzaman, Adeeba Parasakthi, N. Van, P.H. Carlos, C. So, T. Ng, T.K. Shibl, A. High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study) |
| title | High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study) |
| title_full | High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study) |
| title_fullStr | High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study) |
| title_full_unstemmed | High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study) |
| title_short | High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study) |
| title_sort | high prevalence of antimicrobial resistance among clinical streptococcus pneumoniae isolates in asia an ansorp study |
| topic | R Medicine |
| url | http://eprints.um.edu.my/4587/1/Song-2004-High_prevalence_of_a.pdf |
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