Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice
Background: Noni fruit is widely consumed in tropical regions of Indonesia to the Hawaiian Islands. The noni plant has a long history of use as a medicinal plant to treat a wide variety of ailments including CNS disorders. The present investigation was designed to evaluate the antipsychotic effect o...
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| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | http://eprints.um.edu.my/5035/1/Antipsychotic-like_activity_of_Noni_%28Morinda_citrifolia_Linn.%29_in_mice.pdf |
| _version_ | 1825719029273198592 |
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| author | Pandy, V. Narasingam, M. Mohamed, Z. |
| author_facet | Pandy, V. Narasingam, M. Mohamed, Z. |
| author_sort | Pandy, V. |
| collection | UM |
| description | Background: Noni fruit is widely consumed in tropical regions of Indonesia to the Hawaiian Islands. The noni plant has a long history of use as a medicinal plant to treat a wide variety of ailments including CNS disorders. The present investigation was designed to evaluate the antipsychotic effect of noni fruits (Morinda citrifolia Linn.) using mouse models of apomorphine-induced climbing behaviour and methamphetamine-induced stereotypy (licking, biting, gnawing and sniffing).Methods: In acute study, the methanolic extract of Morinda citrifolia (MMC) at different doses 1, 3, 5, 10 g/kg was administered orally one hour prior to apomorphine (5 mg/kg, i.p) and methamphetamine ( 5 mg/kg, i.p) injection respectively in Swiss albino mice. In chronic studies, (TAHITIAN NONI® Juice, TNJ) was made available freely in daily drinking water at 30, 50 and 100 v/v for 7 days; 30 and 50 v/v for 21 days respectively. On the test day, an equivalent average daily divided dose of TNJ was administered by oral gavage one hour prior to apomorphine treatment. Immediately after apomorphine/ methamphetamine administration, the animals were placed in the cylindrical metal cages and observed for climbing behaviour/ stereotypy and climbing time.Results: The acute treatment of MMC (1, 3, 5, 10 g/kg, p.o) significantly decreased the apomorphine-induced cage climbing behaviour and climbing time in mice in a dose dependent manner. The MMC also significantly inhibited methamphetamine-induced stereotypy behaviour and climbing time in mice dose-dependently. The 7 and 21 days treatment of TNJ in drinking water at 50 and 100v/v significantly alleviated the apomorphine-induced climbing behaviour and climbing time in mice.Conclusions: The present study results demonstrated the antidopaminergic effect of Morinda citrifolia Linn. in mice, suggesting that noni has antipsychotic-like activity which can be utilized in the treatment of psychiatric disorders. However further studies are warranted to identify the active principles responsible for the antipsychotic activity of noni. © 2012 Pandy et al.; licensee BioMed Central Ltd. |
| first_indexed | 2024-03-06T05:13:24Z |
| format | Article |
| id | um.eprints-5035 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:13:24Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | um.eprints-50352013-03-07T02:36:50Z http://eprints.um.edu.my/5035/ Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice Pandy, V. Narasingam, M. Mohamed, Z. R Medicine Background: Noni fruit is widely consumed in tropical regions of Indonesia to the Hawaiian Islands. The noni plant has a long history of use as a medicinal plant to treat a wide variety of ailments including CNS disorders. The present investigation was designed to evaluate the antipsychotic effect of noni fruits (Morinda citrifolia Linn.) using mouse models of apomorphine-induced climbing behaviour and methamphetamine-induced stereotypy (licking, biting, gnawing and sniffing).Methods: In acute study, the methanolic extract of Morinda citrifolia (MMC) at different doses 1, 3, 5, 10 g/kg was administered orally one hour prior to apomorphine (5 mg/kg, i.p) and methamphetamine ( 5 mg/kg, i.p) injection respectively in Swiss albino mice. In chronic studies, (TAHITIAN NONI® Juice, TNJ) was made available freely in daily drinking water at 30, 50 and 100 v/v for 7 days; 30 and 50 v/v for 21 days respectively. On the test day, an equivalent average daily divided dose of TNJ was administered by oral gavage one hour prior to apomorphine treatment. Immediately after apomorphine/ methamphetamine administration, the animals were placed in the cylindrical metal cages and observed for climbing behaviour/ stereotypy and climbing time.Results: The acute treatment of MMC (1, 3, 5, 10 g/kg, p.o) significantly decreased the apomorphine-induced cage climbing behaviour and climbing time in mice in a dose dependent manner. The MMC also significantly inhibited methamphetamine-induced stereotypy behaviour and climbing time in mice dose-dependently. The 7 and 21 days treatment of TNJ in drinking water at 50 and 100v/v significantly alleviated the apomorphine-induced climbing behaviour and climbing time in mice.Conclusions: The present study results demonstrated the antidopaminergic effect of Morinda citrifolia Linn. in mice, suggesting that noni has antipsychotic-like activity which can be utilized in the treatment of psychiatric disorders. However further studies are warranted to identify the active principles responsible for the antipsychotic activity of noni. © 2012 Pandy et al.; licensee BioMed Central Ltd. 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/5035/1/Antipsychotic-like_activity_of_Noni_%28Morinda_citrifolia_Linn.%29_in_mice.pdf Pandy, V. and Narasingam, M. and Mohamed, Z. (2012) Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice. BMC Complementary and Alternative Medicine, 12. ISSN 1472-6882 , DOI https://doi.org/10.1186/1472-6882-12-186 <https://doi.org/10.1186/1472-6882-12-186>. 10.1186/1472-6882-12-186 |
| spellingShingle | R Medicine Pandy, V. Narasingam, M. Mohamed, Z. Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice |
| title | Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice |
| title_full | Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice |
| title_fullStr | Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice |
| title_full_unstemmed | Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice |
| title_short | Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice |
| title_sort | antipsychotic like activity of noni morinda citrifolia linn in mice |
| topic | R Medicine |
| url | http://eprints.um.edu.my/5035/1/Antipsychotic-like_activity_of_Noni_%28Morinda_citrifolia_Linn.%29_in_mice.pdf |
| work_keys_str_mv | AT pandyv antipsychoticlikeactivityofnonimorindacitrifolialinninmice AT narasingamm antipsychoticlikeactivityofnonimorindacitrifolialinninmice AT mohamedz antipsychoticlikeactivityofnonimorindacitrifolialinninmice |