Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt
Azadirachta indica is widely used in traditional medicine to treat diabetes and hypertension. In the present study A. indica-yogurt was prepared and refrigerated up to 28 days. pH of A. indica-yogurt was lower whereas total titratable acid (TTA) was higher than plain-yogurt during storage. The total...
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| Format: | Article |
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2011
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| author | Shori, A.B. Baba, A.S.H. |
| author_facet | Shori, A.B. Baba, A.S.H. |
| author_sort | Shori, A.B. |
| collection | UM |
| description | Azadirachta indica is widely used in traditional medicine to treat diabetes and hypertension. In the present study A. indica-yogurt was prepared and refrigerated up to 28 days. pH of A. indica-yogurt was lower whereas total titratable acid (TTA) was higher than plain-yogurt during storage. The total phenolic content (TPC) and antioxidant capacity increased during storage. A. indica-yogurt had highest TPC (74.9 ± 5.1 μgGAE/ml; p < 0.05) on day 28 and DPPH inhibition (53.1 ± 5.0%; p < 0.05) on day 14 compared to plain-yogurt (29.6 ± 1.1 μgGAE/ml and 35.9 ± 5.2%, respectively). The OPA values increased between day 7 and 21 of storage but reduced on the 4th week of storage with values for A. indica-yogurt being higher (p < 0.05) than plain-yogurts. Maximum inhibition of α-amylase (47.4 ± 5.8%), α-glucosidase (15.2 ± 2.5%) and angiotensin-1 converting enzyme (ACE, 48.4 ± 7.2%) by plain-yogurt water extract occurred on day 7, 14 and 0, respectively. A. indica-yogurt water extract increased the inhibition to maximal values for α-glucosidase and ACE on day 14 of storage (15.9 ± 10.1% and 79.70 ± 11.2%, respectively) and for α-amylase on day 21 of storage (54.8 ± 3.2%). A. indica-yogurt has higher TPC, antioxidant activities and enzymes inhibitory effects than plain-yogurt. Thus A. indica-yogurt may have the potential to serve as enhanced functional yogurt with anti-diabetic and anti-hypertension activities. © 2011. |
| first_indexed | 2024-03-06T05:16:50Z |
| format | Article |
| id | um.eprints-6657 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:16:50Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | um.eprints-66572013-12-11T02:26:13Z http://eprints.um.edu.my/6657/ Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt Shori, A.B. Baba, A.S.H. QH301 Biology Azadirachta indica is widely used in traditional medicine to treat diabetes and hypertension. In the present study A. indica-yogurt was prepared and refrigerated up to 28 days. pH of A. indica-yogurt was lower whereas total titratable acid (TTA) was higher than plain-yogurt during storage. The total phenolic content (TPC) and antioxidant capacity increased during storage. A. indica-yogurt had highest TPC (74.9 ± 5.1 μgGAE/ml; p < 0.05) on day 28 and DPPH inhibition (53.1 ± 5.0%; p < 0.05) on day 14 compared to plain-yogurt (29.6 ± 1.1 μgGAE/ml and 35.9 ± 5.2%, respectively). The OPA values increased between day 7 and 21 of storage but reduced on the 4th week of storage with values for A. indica-yogurt being higher (p < 0.05) than plain-yogurts. Maximum inhibition of α-amylase (47.4 ± 5.8%), α-glucosidase (15.2 ± 2.5%) and angiotensin-1 converting enzyme (ACE, 48.4 ± 7.2%) by plain-yogurt water extract occurred on day 7, 14 and 0, respectively. A. indica-yogurt water extract increased the inhibition to maximal values for α-glucosidase and ACE on day 14 of storage (15.9 ± 10.1% and 79.70 ± 11.2%, respectively) and for α-amylase on day 21 of storage (54.8 ± 3.2%). A. indica-yogurt has higher TPC, antioxidant activities and enzymes inhibitory effects than plain-yogurt. Thus A. indica-yogurt may have the potential to serve as enhanced functional yogurt with anti-diabetic and anti-hypertension activities. © 2011. 2011 Article PeerReviewed Shori, A.B. and Baba, A.S.H. (2011) Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt. Journal of Saudi Chemical Society. ISSN 13196103, DOI https://doi.org/10.1016/j.jscs.2011.04.006 <https://doi.org/10.1016/j.jscs.2011.04.006>. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955176483&partnerID=40&md5=550ba8149c3098402f4735a9b5ec322a 10.1016/j.jscs.2011.04.006 |
| spellingShingle | QH301 Biology Shori, A.B. Baba, A.S.H. Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt |
| title | Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt |
| title_full | Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt |
| title_fullStr | Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt |
| title_full_unstemmed | Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt |
| title_short | Antioxidant activity and inhibition of key enzymes linked to type-2 diabetes and hypertension by azadirachta indica-yogurt |
| title_sort | antioxidant activity and inhibition of key enzymes linked to type 2 diabetes and hypertension by azadirachta indica yogurt |
| topic | QH301 Biology |
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