Optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method
The purpose of this study was to optimize the parameters involved in the production of water-soluble phytosterol microemulsions for use in the food industry. In this study, response surface methodology (RSM) was employed to model and optimize four of the processing parameters, namely, the number of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Published: |
2009
|
| Subjects: |
| _version_ | 1796945484883951616 |
|---|---|
| author | Leong, W.F. Che Man, Y.B. Lai, O.M. Long, K. Misran, M. Tan, C.P. |
| author_facet | Leong, W.F. Che Man, Y.B. Lai, O.M. Long, K. Misran, M. Tan, C.P. |
| author_sort | Leong, W.F. |
| collection | UM |
| description | The purpose of this study was to optimize the parameters involved in the production of water-soluble phytosterol microemulsions for use in the food industry. In this study, response surface methodology (RSM) was employed to model and optimize four of the processing parameters, namely, the number of cycles of high-pressure homogenization (1-9 cycles), the pressure used for high-pressure homogenization (100-500 bar), the evaporation temperature (30-70 °C), and the concentration ratio of microemulsions (1-5). All responses-particle size (PS), polydispersity index (PDI), and percent ethanol residual (ER)-were well fit by a reduced cubic model obtained by multiple regression after manual elimination. The coefficient of determination (R 2) and absolute average deviation (AAD) value for PS, PDI, and ER were 0.9628 and 0.5398, 0.9953 and 0.7077, and 0.9989 and 1.0457, respectively. The optimized processing parameters were 4.88 (approximately 5) homogenization cycles, homogenization pressure of 400 bar, evaporation temperature of 44.5 0C, and concentration ratio of microemulsions of 2.34 cycles (approximately 2 cycles) of high-pressure homogenization. The corresponding responses for the optimized preparation condition were a minimal particle size of 328 nm, minimal polydispersity index of 0.159, and <0.1 of ethanol residual. The chi-square test verified the model, whereby the experimental values of PS, PDI, and ER agreed with the predicted values at a 0.05 level of significance. |
| first_indexed | 2024-03-06T05:17:19Z |
| format | Article |
| id | um.eprints-6851 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:17:19Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | um.eprints-68512013-12-11T07:05:38Z http://eprints.um.edu.my/6851/ Optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method Leong, W.F. Che Man, Y.B. Lai, O.M. Long, K. Misran, M. Tan, C.P. QD Chemistry The purpose of this study was to optimize the parameters involved in the production of water-soluble phytosterol microemulsions for use in the food industry. In this study, response surface methodology (RSM) was employed to model and optimize four of the processing parameters, namely, the number of cycles of high-pressure homogenization (1-9 cycles), the pressure used for high-pressure homogenization (100-500 bar), the evaporation temperature (30-70 °C), and the concentration ratio of microemulsions (1-5). All responses-particle size (PS), polydispersity index (PDI), and percent ethanol residual (ER)-were well fit by a reduced cubic model obtained by multiple regression after manual elimination. The coefficient of determination (R 2) and absolute average deviation (AAD) value for PS, PDI, and ER were 0.9628 and 0.5398, 0.9953 and 0.7077, and 0.9989 and 1.0457, respectively. The optimized processing parameters were 4.88 (approximately 5) homogenization cycles, homogenization pressure of 400 bar, evaporation temperature of 44.5 0C, and concentration ratio of microemulsions of 2.34 cycles (approximately 2 cycles) of high-pressure homogenization. The corresponding responses for the optimized preparation condition were a minimal particle size of 328 nm, minimal polydispersity index of 0.159, and <0.1 of ethanol residual. The chi-square test verified the model, whereby the experimental values of PS, PDI, and ER agreed with the predicted values at a 0.05 level of significance. 2009 Article PeerReviewed Leong, W.F. and Che Man, Y.B. and Lai, O.M. and Long, K. and Misran, M. and Tan, C.P. (2009) Optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method. Journal of Agricultural and Food Chemistry, 57 (18). pp. 8426-8433. ISSN 0021-8561 , DOI https://doi.org/10.1021/jf901853y <https://doi.org/10.1021/jf901853y>. 10.1021/jf901853y |
| spellingShingle | QD Chemistry Leong, W.F. Che Man, Y.B. Lai, O.M. Long, K. Misran, M. Tan, C.P. Optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method |
| title | Optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method |
| title_full | Optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method |
| title_fullStr | Optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method |
| title_full_unstemmed | Optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method |
| title_short | Optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method |
| title_sort | optimization of processing parameters for the preparation of phytosterol microemulsions by the solvent displacement method |
| topic | QD Chemistry |
| work_keys_str_mv | AT leongwf optimizationofprocessingparametersforthepreparationofphytosterolmicroemulsionsbythesolventdisplacementmethod AT chemanyb optimizationofprocessingparametersforthepreparationofphytosterolmicroemulsionsbythesolventdisplacementmethod AT laiom optimizationofprocessingparametersforthepreparationofphytosterolmicroemulsionsbythesolventdisplacementmethod AT longk optimizationofprocessingparametersforthepreparationofphytosterolmicroemulsionsbythesolventdisplacementmethod AT misranm optimizationofprocessingparametersforthepreparationofphytosterolmicroemulsionsbythesolventdisplacementmethod AT tancp optimizationofprocessingparametersforthepreparationofphytosterolmicroemulsionsbythesolventdisplacementmethod |