Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues.
Disease manifestation, pathology, and tissue tropism following infection with Tioman virus (TioPV), a newly isolated, bat-derived paramyxovirus, was investigated in subcutaneously (n = 12) and oronasally (n = 4) inoculated pigs. Pigs were either asymptomatic or developed pyrexia, but all of the anim...
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| Format: | Article |
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American Society for Microbiology
2008
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| _version_ | 1796944666603552768 |
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| author | Yaiw, K.C. Bingham, John Crameri, Gary Mungall, Bruce Hyatt, Alex Yu, Meng Eaton, Bryan Shamala, Devi Wang, L.F. Thong Wong, Kum |
| author_facet | Yaiw, K.C. Bingham, John Crameri, Gary Mungall, Bruce Hyatt, Alex Yu, Meng Eaton, Bryan Shamala, Devi Wang, L.F. Thong Wong, Kum |
| author_sort | Yaiw, K.C. |
| collection | UM |
| description | Disease manifestation, pathology, and tissue tropism following infection with Tioman virus (TioPV), a newly isolated, bat-derived paramyxovirus, was investigated in subcutaneously (n = 12) and oronasally (n = 4) inoculated pigs. Pigs were either asymptomatic or developed pyrexia, but all of the animals produced neutralizing antibodies. The virus (viral antigen and/or genome) was detected in lymphocytes of the thymus, tonsils, spleen, lymph nodes and Peyer's patches (ileum), tonsillar epithelium, and thymic epithelioreticular cells. Virus was isolated from oral swabs but not from urine. Our findings suggest that the pig could act as an intermediate or amplifying host for TioPV and that oral secretion is a possible means of viral transmission. |
| first_indexed | 2024-03-06T05:05:06Z |
| format | Article |
| id | um.eprints-717 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:05:06Z |
| publishDate | 2008 |
| publisher | American Society for Microbiology |
| record_format | dspace |
| spelling | um.eprints-7172017-07-14T09:29:46Z http://eprints.um.edu.my/717/ Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues. Yaiw, K.C. Bingham, John Crameri, Gary Mungall, Bruce Hyatt, Alex Yu, Meng Eaton, Bryan Shamala, Devi Wang, L.F. Thong Wong, Kum Theories of disease. Etiology. Pathogenesis Disease manifestation, pathology, and tissue tropism following infection with Tioman virus (TioPV), a newly isolated, bat-derived paramyxovirus, was investigated in subcutaneously (n = 12) and oronasally (n = 4) inoculated pigs. Pigs were either asymptomatic or developed pyrexia, but all of the animals produced neutralizing antibodies. The virus (viral antigen and/or genome) was detected in lymphocytes of the thymus, tonsils, spleen, lymph nodes and Peyer's patches (ileum), tonsillar epithelium, and thymic epithelioreticular cells. Virus was isolated from oral swabs but not from urine. Our findings suggest that the pig could act as an intermediate or amplifying host for TioPV and that oral secretion is a possible means of viral transmission. American Society for Microbiology 2008-01 Article PeerReviewed Yaiw, K.C. and Bingham, John and Crameri, Gary and Mungall, Bruce and Hyatt, Alex and Yu, Meng and Eaton, Bryan and Shamala, Devi and Wang, L.F. and Thong Wong, Kum (2008) Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues. Journal of Virology, 82 (1). pp. 565-8. ISSN 0022-538X, DOI 17913804. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224375/ 17913804 |
| spellingShingle | Theories of disease. Etiology. Pathogenesis Yaiw, K.C. Bingham, John Crameri, Gary Mungall, Bruce Hyatt, Alex Yu, Meng Eaton, Bryan Shamala, Devi Wang, L.F. Thong Wong, Kum Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues. |
| title | Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues. |
| title_full | Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues. |
| title_fullStr | Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues. |
| title_full_unstemmed | Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues. |
| title_short | Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues. |
| title_sort | tioman virus a paramyxovirus of bat origin causes mild disease in pigs and has a predilection for lymphoid tissues |
| topic | Theories of disease. Etiology. Pathogenesis |
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