F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review
Oxidative stress (OS) has been implicated as one of the major underlying mechanisms behind many acute and chronic diseases. However, the measurement of free radicals or their end products is complicated. Isoprostanes, derived from the non-enzymatic peroxidation of arachidonic acid are now considered...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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The Society for Free Radical Research Japan
2009
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/7217/1/Kaviarasan-2009-F-2-Isoprostanes_as.pdf |
| _version_ | 1796945542565068800 |
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| author | Kaviarasan, Subramanian Muniandy, Sekaran Qvist, Rajes Ismail, Ikram Shah |
| author_facet | Kaviarasan, Subramanian Muniandy, Sekaran Qvist, Rajes Ismail, Ikram Shah |
| author_sort | Kaviarasan, Subramanian |
| collection | UM |
| description | Oxidative stress (OS) has been implicated as one of the major underlying mechanisms behind many acute and chronic diseases. However, the measurement of free radicals or their end products is complicated. Isoprostanes, derived from the non-enzymatic peroxidation of arachidonic acid are now considered to be reliable biomarkers of oxidant stress in the human body. Isoprostanes are involved in many of the human diseases such as type 2 diabetes. In type 2 diabetes elevated levels of F-2-Isoprostanes (F-2-IsoPs) have been observed. The measurement of bioactive F-2-IsoPs levels offers a unique noninvasive analytical tool to study the role of free radicals in physiology, oxidative stress-related diseases, and acute or chronic inflammatory conditions. Measurement of oxidative stress by various other methods lacks specificity and sensitivity. This review aims to shed light on the implemention of F-2-IsoPs measurement as a gold-standard biomarker of oxidative stress in type 2 diabetics. |
| first_indexed | 2024-03-06T05:18:16Z |
| format | Article |
| id | um.eprints-7217 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:18:16Z |
| publishDate | 2009 |
| publisher | The Society for Free Radical Research Japan |
| record_format | dspace |
| spelling | um.eprints-72172020-12-14T05:30:44Z http://eprints.um.edu.my/7217/ F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review Kaviarasan, Subramanian Muniandy, Sekaran Qvist, Rajes Ismail, Ikram Shah R Medicine Oxidative stress (OS) has been implicated as one of the major underlying mechanisms behind many acute and chronic diseases. However, the measurement of free radicals or their end products is complicated. Isoprostanes, derived from the non-enzymatic peroxidation of arachidonic acid are now considered to be reliable biomarkers of oxidant stress in the human body. Isoprostanes are involved in many of the human diseases such as type 2 diabetes. In type 2 diabetes elevated levels of F-2-Isoprostanes (F-2-IsoPs) have been observed. The measurement of bioactive F-2-IsoPs levels offers a unique noninvasive analytical tool to study the role of free radicals in physiology, oxidative stress-related diseases, and acute or chronic inflammatory conditions. Measurement of oxidative stress by various other methods lacks specificity and sensitivity. This review aims to shed light on the implemention of F-2-IsoPs measurement as a gold-standard biomarker of oxidative stress in type 2 diabetics. The Society for Free Radical Research Japan 2009 Article PeerReviewed application/pdf en http://eprints.um.edu.my/7217/1/Kaviarasan-2009-F-2-Isoprostanes_as.pdf Kaviarasan, Subramanian and Muniandy, Sekaran and Qvist, Rajes and Ismail, Ikram Shah (2009) F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review. Journal of Clinical Biochemistry and Nutrition, 45 (1). pp. 1-8. ISSN 0912-0009, DOI https://doi.org/10.3164/jcbn.08-266 <https://doi.org/10.3164/jcbn.08-266>. https://doi.org/10.3164/jcbn.08-266 doi:10.3164/jcbn.08-266 |
| spellingShingle | R Medicine Kaviarasan, Subramanian Muniandy, Sekaran Qvist, Rajes Ismail, Ikram Shah F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review |
| title | F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review |
| title_full | F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review |
| title_fullStr | F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review |
| title_full_unstemmed | F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review |
| title_short | F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review |
| title_sort | f2 isoprostanes as novel biomarkers for type 2 diabetes a review |
| topic | R Medicine |
| url | http://eprints.um.edu.my/7217/1/Kaviarasan-2009-F-2-Isoprostanes_as.pdf |
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