Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus
Sialic acid, oral glucose and plasma lipids were determined in 70 control subjects age range 20-60 and 150 individuals of age range 20-60 who were offspring of one type 2 diabetic parent. The number of first degree relatives who had impaired glucose tolerance were 50. The total sialic acid concentra...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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2005
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| Online Access: | http://eprints.um.edu.my/7225/1/plasma_sialic_acid_levels.pdf |
| _version_ | 1796945544179875840 |
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| author | Qvist, R. Ismail, I.S. Muniandy, S. Lee, H.F. Chinna, K. Zaini, A. |
| author_facet | Qvist, R. Ismail, I.S. Muniandy, S. Lee, H.F. Chinna, K. Zaini, A. |
| author_sort | Qvist, R. |
| collection | UM |
| description | Sialic acid, oral glucose and plasma lipids were determined in 70 control subjects age range 20-60 and 150 individuals of age range 20-60 who were offspring of one type 2 diabetic parent. The number of first degree relatives who had impaired glucose tolerance were 50. The total sialic acid concentration was significantly higher (p<0.05) in the first degree relatives when compared to the control subjects. However the total sialic acid concentration was significantly higher in the offspring with normal glucose tolerance than those with impaired glucose tolerance. There was no significant difference in the lipids between the control subjects and the offspring with normal glucose tolerance. But the total cholesterol and triglycerides were significantly higher in the offspring with impaired glucose tolerance when compared to the control subjects and the offspring with normal glucose tolerance. Our study shows that the desialylation of the vascular endothelium is an early event that precedes the expression of impaired glucose tolerance or any lipid changes in asymptomatic offspring of one type 2 diabetic parent. |
| first_indexed | 2024-03-06T05:18:17Z |
| format | Article |
| id | um.eprints-7225 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:18:17Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | um.eprints-72252014-10-20T04:03:55Z http://eprints.um.edu.my/7225/ Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus Qvist, R. Ismail, I.S. Muniandy, S. Lee, H.F. Chinna, K. Zaini, A. R Medicine Sialic acid, oral glucose and plasma lipids were determined in 70 control subjects age range 20-60 and 150 individuals of age range 20-60 who were offspring of one type 2 diabetic parent. The number of first degree relatives who had impaired glucose tolerance were 50. The total sialic acid concentration was significantly higher (p<0.05) in the first degree relatives when compared to the control subjects. However the total sialic acid concentration was significantly higher in the offspring with normal glucose tolerance than those with impaired glucose tolerance. There was no significant difference in the lipids between the control subjects and the offspring with normal glucose tolerance. But the total cholesterol and triglycerides were significantly higher in the offspring with impaired glucose tolerance when compared to the control subjects and the offspring with normal glucose tolerance. Our study shows that the desialylation of the vascular endothelium is an early event that precedes the expression of impaired glucose tolerance or any lipid changes in asymptomatic offspring of one type 2 diabetic parent. 2005 Article PeerReviewed application/pdf en http://eprints.um.edu.my/7225/1/plasma_sialic_acid_levels.pdf Qvist, R. and Ismail, I.S. and Muniandy, S. and Lee, H.F. and Chinna, K. and Zaini, A. (2005) Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus. Biomedical Research, 16 (3). pp. 213-217. ISSN 0970-938X, http://www.biomedres.org/journal/pdf/116.pdf |
| spellingShingle | R Medicine Qvist, R. Ismail, I.S. Muniandy, S. Lee, H.F. Chinna, K. Zaini, A. Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus |
| title | Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus |
| title_full | Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus |
| title_fullStr | Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus |
| title_full_unstemmed | Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus |
| title_short | Plasma sialic acid levels in the offspring of one parent with Type 2 diabetes mellitus |
| title_sort | plasma sialic acid levels in the offspring of one parent with type 2 diabetes mellitus |
| topic | R Medicine |
| url | http://eprints.um.edu.my/7225/1/plasma_sialic_acid_levels.pdf |
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