Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011
From 1989 to 2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17 years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal c...
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| Format: | Article |
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Elsevier
2013
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| author | Khor, C.S. Sam, I.C. Hooi, P.S. Chan, Yoke Fun |
| author_facet | Khor, C.S. Sam, I.C. Hooi, P.S. Chan, Yoke Fun |
| author_sort | Khor, C.S. |
| collection | UM |
| description | From 1989 to 2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17 years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal clustering with RSV strains reported in previous epidemiological studies. Every few years, the existing predominant genotype was replaced by a new genotype. The RSV-A genotypes GA2, GA5 and GA7 were replaced by NA1 and NA2, while BA became the predominant RSV-B genotype. A unique local cluster, BA12, was seen in 2009, and the recently-described ON1 genotype with 72-nt duplication emerged in 2011. Our findings will have important implications for future vaccine intervention. |
| first_indexed | 2024-03-06T05:18:24Z |
| format | Article |
| id | um.eprints-7270 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:18:24Z |
| publishDate | 2013 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-72702019-05-07T08:14:50Z http://eprints.um.edu.my/7270/ Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011 Khor, C.S. Sam, I.C. Hooi, P.S. Chan, Yoke Fun R Medicine From 1989 to 2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17 years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal clustering with RSV strains reported in previous epidemiological studies. Every few years, the existing predominant genotype was replaced by a new genotype. The RSV-A genotypes GA2, GA5 and GA7 were replaced by NA1 and NA2, while BA became the predominant RSV-B genotype. A unique local cluster, BA12, was seen in 2009, and the recently-described ON1 genotype with 72-nt duplication emerged in 2011. Our findings will have important implications for future vaccine intervention. Elsevier 2013 Article PeerReviewed Khor, C.S. and Sam, I.C. and Hooi, P.S. and Chan, Yoke Fun (2013) Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011. Infection, Genetics and Evolution, 14. pp. 357-360. ISSN 1567-1348, |
| spellingShingle | R Medicine Khor, C.S. Sam, I.C. Hooi, P.S. Chan, Yoke Fun Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011 |
| title | Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011 |
| title_full | Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011 |
| title_fullStr | Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011 |
| title_full_unstemmed | Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011 |
| title_short | Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011 |
| title_sort | displacement of predominant respiratory syncytial virus genotypes in malaysia between 1989 2011 |
| topic | R Medicine |
| work_keys_str_mv | AT khorcs displacementofpredominantrespiratorysyncytialvirusgenotypesinmalaysiabetween19892011 AT samic displacementofpredominantrespiratorysyncytialvirusgenotypesinmalaysiabetween19892011 AT hooips displacementofpredominantrespiratorysyncytialvirusgenotypesinmalaysiabetween19892011 AT chanyokefun displacementofpredominantrespiratorysyncytialvirusgenotypesinmalaysiabetween19892011 |