Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
Perfluorooctanesulfonyl fluoride based compounds have been used in a wide variety of consumer products, such as carpets, upholstery, and textiles. These compounds degrade to perfluorooctanesulfonate (PFOS), a persistent metabolite that accumulates in tissues of humans and wildlife. Previous studies...
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| Format: | Article |
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2004
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| author | Kannan, K. Corsolini, S. Falandysz, J. Fillmann, G. Kumar, K.S. Loganathan, B.G. Mohd, M.A. Olivero, J. Van Wouwe, N. Yang, J.H. Aldous, K.M. |
| author_facet | Kannan, K. Corsolini, S. Falandysz, J. Fillmann, G. Kumar, K.S. Loganathan, B.G. Mohd, M.A. Olivero, J. Van Wouwe, N. Yang, J.H. Aldous, K.M. |
| author_sort | Kannan, K. |
| collection | UM |
| description | Perfluorooctanesulfonyl fluoride based compounds have been used in a wide variety of consumer products, such as carpets, upholstery, and textiles. These compounds degrade to perfluorooctanesulfonate (PFOS), a persistent metabolite that accumulates in tissues of humans and wildlife. Previous studies have reported the occurrence of PFOS, perfluorohexanesulfonate (PFHxS), perfluorooctanoate (PFOA), and perfluorooctanesulfonamide (PFOSA) in human sera collected from the United States. In this study, concentrations of PFOS, PFHxS, PFOA, and PFOSA were measured in 473 human blood/serum/plasma samples collected from the United States, Colombia, Brazil, Belgium, Italy, Poland, India, Malaysia, and Korea. Among the four perfluorochemicals measured, PFOS was the predominant compound found in blood. Concentrations of PFOS were the highest in the samples collected from the United States and Poland (>30 ng/mL); moderate in Korea, Belgium, Malaysia, Brazil, Italy, and Colombia (3 to 29 ng/mL); and lowest in India (<3 ng/mL). PFOA was the next most abundant perfluorochemical in blood samples, although the frequency of occurrence of this compound was relatively low. No age- or gender-related differences in the concentrations of PFOS and PFOA were found in serum samples. The degree of association between the concentrations of four perfluorochernicals varied, depending on the origin of the samples. These results suggested the existence of sources with varying levels and compositions of perfluorochemicals, and differences in exposure patterns to these chemicals, in various countries. In addition to the four target fluorochemicals measured, qualitative analysis of selected blood samples showed the presence of other perfluorochernicals such as perfluoro-decanesulfonate (PFDS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluorododecanoic acid (PFDoA), and perfluoroundecanoic acid (PFUnDA) in serum samples, at concentrations approximately 5- to 10-fold lower than the concentration of PFOS. Further studies should focus on identifying sources and pathways of human exposure to perfluorochernicals. |
| first_indexed | 2024-03-06T05:19:09Z |
| format | Article |
| id | um.eprints-7627 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:19:09Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | um.eprints-76272013-08-12T01:02:45Z http://eprints.um.edu.my/7627/ Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries Kannan, K. Corsolini, S. Falandysz, J. Fillmann, G. Kumar, K.S. Loganathan, B.G. Mohd, M.A. Olivero, J. Van Wouwe, N. Yang, J.H. Aldous, K.M. R Medicine Perfluorooctanesulfonyl fluoride based compounds have been used in a wide variety of consumer products, such as carpets, upholstery, and textiles. These compounds degrade to perfluorooctanesulfonate (PFOS), a persistent metabolite that accumulates in tissues of humans and wildlife. Previous studies have reported the occurrence of PFOS, perfluorohexanesulfonate (PFHxS), perfluorooctanoate (PFOA), and perfluorooctanesulfonamide (PFOSA) in human sera collected from the United States. In this study, concentrations of PFOS, PFHxS, PFOA, and PFOSA were measured in 473 human blood/serum/plasma samples collected from the United States, Colombia, Brazil, Belgium, Italy, Poland, India, Malaysia, and Korea. Among the four perfluorochemicals measured, PFOS was the predominant compound found in blood. Concentrations of PFOS were the highest in the samples collected from the United States and Poland (>30 ng/mL); moderate in Korea, Belgium, Malaysia, Brazil, Italy, and Colombia (3 to 29 ng/mL); and lowest in India (<3 ng/mL). PFOA was the next most abundant perfluorochemical in blood samples, although the frequency of occurrence of this compound was relatively low. No age- or gender-related differences in the concentrations of PFOS and PFOA were found in serum samples. The degree of association between the concentrations of four perfluorochernicals varied, depending on the origin of the samples. These results suggested the existence of sources with varying levels and compositions of perfluorochemicals, and differences in exposure patterns to these chemicals, in various countries. In addition to the four target fluorochemicals measured, qualitative analysis of selected blood samples showed the presence of other perfluorochernicals such as perfluoro-decanesulfonate (PFDS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluorododecanoic acid (PFDoA), and perfluoroundecanoic acid (PFUnDA) in serum samples, at concentrations approximately 5- to 10-fold lower than the concentration of PFOS. Further studies should focus on identifying sources and pathways of human exposure to perfluorochernicals. 2004 Article PeerReviewed Kannan, K. and Corsolini, S. and Falandysz, J. and Fillmann, G. and Kumar, K.S. and Loganathan, B.G. and Mohd, M.A. and Olivero, J. and Van Wouwe, N. and Yang, J.H. and Aldous, K.M. (2004) Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries. Environmental Science & Technology, 38 (17). pp. 4489-4495. ISSN 0013-936X, DOI https://doi.org/10.1021/es0493446 <https://doi.org/10.1021/es0493446>. http://pubs.acs.org/doi/pdfplus/10.1021/es0493446 10.1021/es0493446 |
| spellingShingle | R Medicine Kannan, K. Corsolini, S. Falandysz, J. Fillmann, G. Kumar, K.S. Loganathan, B.G. Mohd, M.A. Olivero, J. Van Wouwe, N. Yang, J.H. Aldous, K.M. Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries |
| title | Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries |
| title_full | Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries |
| title_fullStr | Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries |
| title_full_unstemmed | Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries |
| title_short | Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries |
| title_sort | perfluorooctanesulfonate and related fluorochemicals in human blood from several countries |
| topic | R Medicine |
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