Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta
From the rhizomes of Kaempferia galanga, ethyl cinnamate (EC) was isolated and its vasorelaxant effect was examined on the rat aorta. EC inhibited the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dependent manner, with respective IC50 values of 0.30 +/- 0.05 mM and...
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| Format: | Article |
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2002
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| author | Othman, R. Ibrahim, H. Mohd, M.A. Awang, Khalijah Gilani, A.U.H. Mustafa, Mohd Rais |
| author_facet | Othman, R. Ibrahim, H. Mohd, M.A. Awang, Khalijah Gilani, A.U.H. Mustafa, Mohd Rais |
| author_sort | Othman, R. |
| collection | UM |
| description | From the rhizomes of Kaempferia galanga, ethyl cinnamate (EC) was isolated and its vasorelaxant effect was examined on the rat aorta. EC inhibited the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dependent manner, with respective IC50 values of 0.30 +/- 0.05 mM and 0.38 +/- 0.04 mM. The relaxant effect against PE-induced contractions was greater in the presence of endothelium. Pre-treatment of the aorta with methylene blue and indomethacin significantly reduced the relaxant effect. These results suggest that the inhibitory effects of EC may involve inhibition of Ca2+ influx into vascular cells and release of nitric oxide (NO) and prostacyclin from the endothelial cells. Thus, the vasorelaxant effect of EC mediated through multiple pathways may explain the traditional use of the parent plant in treating hypertension. |
| first_indexed | 2024-03-06T05:19:11Z |
| format | Article |
| id | um.eprints-7639 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:19:11Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | um.eprints-76392019-03-01T09:16:32Z http://eprints.um.edu.my/7639/ Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta Othman, R. Ibrahim, H. Mohd, M.A. Awang, Khalijah Gilani, A.U.H. Mustafa, Mohd Rais R Medicine From the rhizomes of Kaempferia galanga, ethyl cinnamate (EC) was isolated and its vasorelaxant effect was examined on the rat aorta. EC inhibited the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dependent manner, with respective IC50 values of 0.30 +/- 0.05 mM and 0.38 +/- 0.04 mM. The relaxant effect against PE-induced contractions was greater in the presence of endothelium. Pre-treatment of the aorta with methylene blue and indomethacin significantly reduced the relaxant effect. These results suggest that the inhibitory effects of EC may involve inhibition of Ca2+ influx into vascular cells and release of nitric oxide (NO) and prostacyclin from the endothelial cells. Thus, the vasorelaxant effect of EC mediated through multiple pathways may explain the traditional use of the parent plant in treating hypertension. 2002 Article PeerReviewed Othman, R. and Ibrahim, H. and Mohd, M.A. and Awang, Khalijah and Gilani, A.U.H. and Mustafa, Mohd Rais (2002) Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta. Planta Medica, 68 (7). pp. 655-657. ISSN 0032-0943, DOI https://doi.org/10.1055/s-2002-32900 <https://doi.org/10.1055/s-2002-32900>. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2002-32900 10.1055/s-2002-32900 |
| spellingShingle | R Medicine Othman, R. Ibrahim, H. Mohd, M.A. Awang, Khalijah Gilani, A.U.H. Mustafa, Mohd Rais Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta |
| title | Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta |
| title_full | Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta |
| title_fullStr | Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta |
| title_full_unstemmed | Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta |
| title_short | Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta |
| title_sort | vasorelaxant effects of ethyl cinnamate isolated from kaempferia galanga on smooth muscles of the rat aorta |
| topic | R Medicine |
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